Navigation Links
Synthetic protein amplifies genes needed for stem cells
Date:2/16/2012

Scientists have found a way to generate and maintain stem cells much more efficiently by amplifying the effect of an essential protein.

Researchers from Denmark, Scotland and the USA have created synthetic versions of a protein, which manipulates adult cells such as skin cells so that they can subsequently revert to an earlier, embryonic like state. These reverted cells have the potential to become any cell in the body.

As well as reverting adult cells to this state known as induced pluripotent stem cells , the protein also plays a key role in maintaining embryonic stem cells in a pure form. If the protein Oct4 is not present, the embryonic stem cells will start to differentiate into specific cells.

In order to reprogamme adult cells to have stem cell properties viruses need to be added to cell cultures to trigger production of significant quantities of Oct4.

Oct4 plays a powerful role in regulating stem cell genes. However, while large quantities of Oct4 are needed too much of it can ruin the properties of stem cells.

Scientists, whose work is published in the journal Cell Reports, were able to overcome this by producing a synthetic version of Oct4 that amplified the effect of the protein in its natural form.

The synthetic version of Oct4 was much more efficient in turning on genes that instruct cells on how to be stem cells and, as a result, the cells did not need as much Oct4 for either reprogramming or to remain as stem cells thereby eliminating problems caused by too much Oct4.

In fact, the synthetic Oct4 could support stem cells under conditions that they do not normally grow. These findings could also help scientists find new ways generate stem cells in the laboratory.

The study showed that Oct4 was mainly responsible for turning on genes that instruct cells on how to become stem cells, rather than turning off genes that encourage the cells to differentiate.

"Our discovery is an important step towa
'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
2. Synthetic Biology: Coming Up Fast!
3. Biosynthetics production with detours
4. UNC scientists teach enzyme to make synthetic heparin in more varieties
5. Synthetic virus supports a bat origin for SARS
6. Synthetic biology: Is ethics a showstopper?
7. Synthetic biology key in the 21st century
8. Milestone achieved toward production of malaria treatment using synthetic biology and fermentation
9. Synthetic biology can help extend anti-malaria drug effectiveness
10. Orientation of antenna protein in photosynthetic bacteria described
11. Using combinatorial libraries to engineer genetic circuits advances synthetic biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data ... physiologic monitoring, has released a new series of ... of preclinical toxicology researchers. M series, part of ... toxicologists collect the best possible physiologic data when ... Adding functional endpoints to toxicology studies has ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... The Organic Electronics research group at Linkping University previously ... negative ions, as well as biomolecules. Tybrandt has now ... in a similar way to traditional silicon-based electronics. ... charge carrier consists of chemical substances with various functions. ...
... in southeast Greenland are retreating rapidly with the ongoing global ... shows that the glaciers can recuperate within a short timeframe ... a collection of Danish aerial photos combined with both old ... scientific results have created international attention and have been published ...
... 2010 to measure sea-ice thickness in the Arctic, but data ... studies. High-resolution mapping of the topography of the ocean floor ... The main objective of the polar-orbiting CryoSat is to measure ... the ice sheets that blanket Greenland and Antarctica. ,But the ...
Cached Biology News:Old aerial photos supply new knowledge on glaciers in Greenland 2Old aerial photos supply new knowledge on glaciers in Greenland 3CryoSat goes to sea 2
(Date:12/24/2014)... PharmaBoardroom,s new report, , Healthcare and Life ... free download , digs deep into this vibrant market, speaking ... today. One area where Algeria ... homegrown pharmaceutical manufacturing base, even if the government,s ambitious target ... A cursory comparison with neighboring Morocco ...
(Date:12/24/2014)... and NEW YORK , ... from its open-label pilot study of mazindol in children ... Development and Therapy in December 2014 . ... mazindol in children with attention deficit/hyperactivity disorder" ( Konofal ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ - RepliCel Life Sciences ... medicine company focused on the development of autologous cell ... of the University of Calgary in conjunction with co-authors ... which further validates the company,s ongoing clinical research using ... of pattern baldness. The paper entitled " ...
(Date:12/22/2014)... , Dec. 22, 2014  ( www.competitivehealth.com ) — ... online medical bill review and advocacy service, has signed ... FREE WellCard Savings discount health services marketplace. ... was more than they expected to pay. As part ... care costs, WellCard Savings is pleased to offer medical ...
Breaking Biology Technology:PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2
... , , , , , ... Eppendorf 5 Prime, Inc. , , , , ... Buccal swabs are the least invasive way of collecting gDNA from humans, , ... , pathogens. Buccal swabs are quickly becoming the method of ...
... , , , , , , ... Each contribution published will be acknowledged with a set of electroporation , ... , Protocols for Bacteria, Yeast, Fungi , ... <A , ...
... , , Kurt Lucas, Eppendorf AG , , ... Significance of cell fusion , ... methods in modern biology, such as the production of monoclonal antibodies, , ... , chemically induced cell fusion via polyethylene glycol (PEG), electrical ...
Cached Biology Technology:Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 2Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 3Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 4Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 5Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 2Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 3Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 4Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 5Principles and applications of electrical cell fusion 2Principles and applications of electrical cell fusion 3Principles and applications of electrical cell fusion 4Principles and applications of electrical cell fusion 5
XPLAC (S-17)...
Useful for determination of glucose and ATP. Packaging: Package sizes are based on hexokinase units. Preparation Unit Definition: One unit will phosphorylate 1.0 mol of D -glucose per min at pH ...
... Lyophilized powder containing Tris ... Definition: One unit will ... to phospho(enol)pyruvate per min ... C. Chem comp: Protein ...
SCCRO (S-17)...
Biology Products: