Navigation Links
Synthetic moleculues could add spice to fight against cancer
Date:8/17/2008

COLUMBUS, Ohio Seeking to improve on nature, scientists used a spice-based compound as a starting point and developed synthetic molecules that, in lab settings, are able to kill cancer cells and stop the cells from spreading.

The researchers are combining organic chemistry, computer-aided design and molecular biology techniques in developing and testing pharmaceutical compounds that can fight breast and prostate cancer cells. The synthetic molecules are derived from curcumin, a naturally occurring compound found in the spice turmeric.

Centuries of anecdotal evidence and recent scientific research suggest curcumin has multiple disease-fighting features, including anti-tumor properties. However, when eaten, curcumin is not absorbed well by the body. Instead, most ingested curcumin in food or supplement form remains in the gastrointestinal system and is eliminated before it is able to enter the bloodstream or tissues.

"Newer evidence describes how curcumin interacts with certain proteins to generate anti-cancer activity inside the body. We're focusing on the pathways that are most involved in cancer and trying to optimize for those properties," said James Fuchs, assistant professor of medicinal chemistry and pharmacognosy at Ohio State University and principal investigator on the project.

Fuchs presented the research today (8/17) at the American Chemical Society meeting in Philadelphia. He described a selection of the 40 compounds developed to date, emphasizing the synthetic molecules that appear to have the most potential to serve as the basis for anti-cancer drug development.

Fuchs and colleagues are continuing to refine compounds that are best structured to interact with a few overactive proteins that are associated with cell activity in breast and prostate cancers. Blocking these molecular targets can initiate cell death or stop cell migration in the cancers.

A major component of their strategy is called
'/>"/>

Contact: James Fuchs
Fuchs.42@osu.edu
614-247-7377
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Synthetic molecules emulate enzyme behavior for the first time
2. Synthetic cocoa chemical slows growth of tumors in human cell lines
3. Synthetic Biology: funders move to address social and ethical challenges
4. New projects to raise UK profile in synthetic biology
5. Oregano oil works as well as synthetic insecticides to tackle common beetle pest
6. Berkeley researchers identify photosynthetic dimmer switch
7. Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
8. Researchers decode genetics of rare photosynthetic bacterium
9. Researchers decode genetics of rare photosynthetic bacteria
10. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
11. Synthetic compound promotes death of lung-cancer cells, tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
(Date:3/23/2015)... March 23, 2015  In the 2014 fiscal year, ... conviction losses. This figure accounts for a fraction of ... The Nilson Report, exceeds $11 billion globally. The polygraph ... a crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test ...
(Date:3/20/2015)... , Mar. 20, 2015 Research and Markets ... addition of the "India Sensors Market Forecast ... The sensor market is projected to ... Consumer electronics, automotive, industrial and healthcare ... in the country. In addition, adoption of MEMS ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... Two junior researchers from Ludwig-Maximilians-Universitt (LMU) in Munich ... European Research Council (ERC). Professor Jens Michaelis, Department ... Vhringer, Institute of Immunology, shall receive grants amounting ... years. With its Starting Grant, the ERC supports ...
... DALLAS Oct. 27, 2009 UT Southwestern Medical ... Texas to receive the newest generation of a mechanical device ... while he awaits a heart transplant. Called a left-ventricular ... weakened heart pump blood throughout the body. For Mr. LeBlanc, ...
... WALL, N.J., Oct. 26 BIO-key International, Inc. (OTC ... software is showcasing donor and patient identity solutions at ... Orleans Convention Center from October 25-27 2009. BIO-key will ... in booth #424. Also, at 5 PM on Monday, ...
Cached Biology News:LMU Munich researchers highly endowed with EU funding 2UT Southwestern patient first in North Texas to receive newest-generation heart failure device 2UT Southwestern patient first in North Texas to receive newest-generation heart failure device 3BIO-key(R) International Exhibiting at AABB TXPO 2
(Date:4/16/2015)... 16, 2015 OncoTAb, Inc., ... (UNC Charlotte) spin-out company, announced today the appointment ... M.D., as Chief Operating Officer (COO). Cooper brings ... in developing clinical diagnostic and biotechnology platforms in ... , Cooper’s extensive career transcends the field of ...
(Date:4/16/2015)... , April 16, 2015 /CNW/ - Bioenterprise Corporation is pleased ... office in Charlottetown , PEI.  Bioenterprise ... Edward Island ADAPT Council for the commercialization of agricultural ... to working with PEI ADAPT.  They have been at ... than a decade," explains Dave Smardon , President ...
(Date:4/16/2015)... DIEGO , April 16, 2015 Avelas ... dedicated to improving cancer surgeries, announced today that it ... fluorescent cancer illuminator, AVB-620, in women with primary, non-recurrent ... the company also welcomed the addition of Steven ... The open label, dose escalation study will ...
(Date:4/16/2015)... 16, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: ... non-toxic DCVax® personalized immune therapies for cancer, announced ... Loncar Cancer Immunotherapy Index (LCINDX), a professional index ... immunotherapy field within the biotechnology space.  ... 25 companies" in the immunotherapy space, including 6 ...
Breaking Biology Technology:OncoTAb Names Dr. David L. Cooper as COO 2Bioenterprise Corporation Expands into the Maritimes 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 3NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3
... 6, 2011 SyntheMed, Inc. ("the Company") (OTCBB: SYMD; Pink ... biotechnology company focused on the treatment of diseases characterized by ... effective September 2, 2011.  The Company changed its name to ... trade on the OTC Bulletin Board, changing to a new ...
... Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN ) today ... Vice President, General Counsel and Secretary.  Mr. LaRosa will ... affairs, including general corporate legal matters, intellectual property and ... M.D., Ph.D., president and chief executive officer. ...
... Genprex, Inc., formerly known as Convergen LifeSciences, ... cancer therapy CNVN202, will be branded as Oncoprex™ . ... brand in the oncology sector in recognition of our advancing ... will be used to unlock the unrealized potential of a ...
Cached Biology Technology:Pathfinder, LLC and SyntheMed, Inc. Complete Merger 2Pathfinder, LLC and SyntheMed, Inc. Complete Merger 3Regeneron Announces Appointment of Joseph J. LaRosa as Senior Vice President, General Counsel and Secretary 2Genprex Announces New Branding 2
Request Info...
384 Cluster Tube Racks...
The antibody recognizes the peptide sequence ESESQGPK (aa 441-448) of human class III beta-tubulin specific for neurones....
... Immunogen: Partially purified chicken ... detects vitamin D receptor (VDR) from ... and fish tissues. This antibody ... glucocorticoid receptors. MA1-710 detects both ...
Biology Products: