Navigation Links
Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
Date:4/4/2008

DALLAS April 4, 2008 Researchers at UT Southwestern Medical Center have developed a simple and inexpensive method to screen small synthetic molecules and pull out a handful that might treat cancer and other diseases less expensively than current methods.

In one screen of more than 300,000 such molecules, called peptoids, the new technique quickly singled out five promising candidates that mimicked an antibody already on the market for treating cancer. One of the compounds blocked the growth of human tumors in a mouse model.

Antibodies are molecules produced by the body to help ward off infection. Natural and manmade antibodies work by latching onto very specific targets such as receptors on the surface of cells.

Many new drugs being made today are antibodies, but they are extremely expensive to make. Financially, the U.S. health care system is going to have a difficult time accommodating the next 500 drugs being antibodies, said Dr. Thomas Kodadek, chief of translational research at UT Southwestern and senior author of the study, which appears online and in an upcoming issue of the Journal of the American Chemical Society.

Our results show that a peptoid can attack a harmful receptor in the body with the same precision as an antibody, but would cost much less to develop, said Dr. Kodadek.

Peptoids are designed in the laboratory to resemble chains of natural molecules called peptides. Some peptides are used as medications, such as insulin or antibodies used to treat some cancers, but because the stomach digests them, most cant be taken by mouth and must be injected.

By contrast, peptoids are resistant to the stomach enzymes that degrade natural peptides, so it is possible that they could be swallowed as a pill. Peptoids are much less expensive and easier to manufacture than antibodies, Dr. Kodadek said. They are also much smaller than antibodies, so they might be better at penetrating tum
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers decode genetics of rare photosynthetic bacterium
2. Researchers decode genetics of rare photosynthetic bacteria
3. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
4. Synthetic compound promotes death of lung-cancer cells, tumors
5. Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues
6. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
7. New book presents methods to poke and prod individual molecules
8. Curry-derived molecules might be too spicy for colorectal cancers
9. New molecules discovered that block cancer cells from modifying cell DNA
10. Clemson scientists shed light on molecules in living cells
11. Button mushrooms contain as much anti-oxidants as expensive ones
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
(Date:9/17/2014)... four-year project, delivering its first release in 2004. After ... several EC projects, as a part of the EC-FP7 ... to increase the general awareness of the work done ... of the Fauna Europaea results, the Biodiversity ... tools to prepare data papers for all 56 major ...
(Date:9/17/2014)... developed, very cleverly, some lessons on how to create ... Joseph Shaw, director of the Optical Technology Center at ... at the nanoscale, we,ll discover them." , Some of ... during a conference called "The Nature of Light: Light ... the University of Arizona College of Optical Sciences. The ...
(Date:9/17/2014)... New research from the Copenhagen Centre for Social Evolution ... evolutionary theory that birth weight and -length can partially ... disorders such as autism and schizophrenia later in life. ... births, and subsequent hospital diagnoses for up to 30 ... factors. The study is published today in the ...
Breaking Biology News(10 mins):Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3
... -- Traditionally addressed through hand-weeding and/or herbicide application, controlling ... production. Increased labor costs have made hand-weeding prohibitive as ... may be effective and less expensive, non-target herbicide loss ... the environment. To address the economic and environmental impact ...
... -- Associate Professor Paul Blowers of the University of ... 2011 Arizona Professor of the Year, recognized for commitment ... Advancement of Teaching and the Council for Advancement and ... announced the award on Nov. 17 in Washington, D.C. ...
... CAMBRIDGE, Mass. -- Significant progress has been ... psychiatric disease. Recent studies have identified common genetic ... significant risk. One example of a rare cause ... (DISC1) gene, first identified in a large Scottish ...
Cached Biology News:Biodegradable mulches successfully control weeds in container-grown arborvitae 2Arizona Engineering associate professor earns national recognition 2Picower: Schizophrenia gene associated with psychiatric disorders and brain development 2Picower: Schizophrenia gene associated with psychiatric disorders and brain development 3
(Date:9/18/2014)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology ... cancer, announced today that Daniel P. Gold , Ph.D., ... NewsMakers in the Biotech Industry conference on Friday, September ... Broadway Hotel & Conference Center in New York ... accessed at www.meipharma.com . A replay will be available ...
(Date:9/18/2014)... 18 septembre 2014 Mapi, société créée ... 1974, a été depuis 40 ans l,un ... cliniques traditionnelles par des évaluations recentrées sur ... les impacts économiques des traitements. ... A cours d,une récente conférence téléphonique ...
(Date:9/18/2014)... SeqLL Inc., the owner of ... today the closing of a $1M Series-A funding ... Diagnostic Technologies, will increase the power of tSMS™ ... in March 2013 by Daniel Jones, a former ... BioSciences, SeqLL has continued to offer Helicos’ sequencing ...
(Date:9/18/2014)... sweeteners, promoted as aids to weight loss and diabetes ... and metabolic disease; and they do it in a ... the gut microbiota the substantial population of bacteria ... experiments in mice and humans, were published today in ... Elinav of the Weizmann Institute,s Immunology Department, who led ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 31974 - 2014 - Mapi fête ses 40 ans 2SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3
... Sweden, July 14 PharmaSurgics AB.,successfully completes Phase ... is safe and well tolerated. Initially developed to ... combines,the pharmacological effect of PXL01 with the physical ... to be the first anti-adhesion drug on the,market. ...
... LA JOLLA, Calif., July 14 Synthetic Genomics ... solutions to address a variety of global challenges including ... and development agreement with ExxonMobil Research and Engineering Company ... algae. , , ...
... , ... today announced clearance for marketing by the United States Food and Drug Administration (K083292) ... , ... 14, 2009 -- EMcision Ltd. today announced clearance for marketing by the United States ...
Cached Biology Technology:Novel Product for the Prevention of Post-Surgical Adhesion Formation Completes Phase I Clinical Study 2Synthetic Genomics Inc. and ExxonMobil Research and Engineering Company Sign Exclusive, Multi-Year Agreement to Develop Next Generation Biofuels Using Photosynthetic Algae 2Synthetic Genomics Inc. and ExxonMobil Research and Engineering Company Sign Exclusive, Multi-Year Agreement to Develop Next Generation Biofuels Using Photosynthetic Algae 3EMcision Announces 510(k) Clearance of the Habib EndoHPB, its Novel Bipolar RF Device for the Palliation of Biliary and Pancreatic Tumours 2
... The MEGAscript RNAi Kit is ... large mass amounts of ready-to-use ... non-mammalian systems. The MEGAscript RNAi ... patented high-yield transcription technol-ogy and ...
UGT1A6 (D-20)...
... With its patented technology, the Lone Wolf ... any Normally Open proportional valve available on ... operation, provides repeatable high-speed performance, and ensures ... , Enhances system control and patient ...
Normal Hamster Serum...
Biology Products: