Navigation Links
Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
Date:4/4/2008

DALLAS April 4, 2008 Researchers at UT Southwestern Medical Center have developed a simple and inexpensive method to screen small synthetic molecules and pull out a handful that might treat cancer and other diseases less expensively than current methods.

In one screen of more than 300,000 such molecules, called peptoids, the new technique quickly singled out five promising candidates that mimicked an antibody already on the market for treating cancer. One of the compounds blocked the growth of human tumors in a mouse model.

Antibodies are molecules produced by the body to help ward off infection. Natural and manmade antibodies work by latching onto very specific targets such as receptors on the surface of cells.

Many new drugs being made today are antibodies, but they are extremely expensive to make. Financially, the U.S. health care system is going to have a difficult time accommodating the next 500 drugs being antibodies, said Dr. Thomas Kodadek, chief of translational research at UT Southwestern and senior author of the study, which appears online and in an upcoming issue of the Journal of the American Chemical Society.

Our results show that a peptoid can attack a harmful receptor in the body with the same precision as an antibody, but would cost much less to develop, said Dr. Kodadek.

Peptoids are designed in the laboratory to resemble chains of natural molecules called peptides. Some peptides are used as medications, such as insulin or antibodies used to treat some cancers, but because the stomach digests them, most cant be taken by mouth and must be injected.

By contrast, peptoids are resistant to the stomach enzymes that degrade natural peptides, so it is possible that they could be swallowed as a pill. Peptoids are much less expensive and easier to manufacture than antibodies, Dr. Kodadek said. They are also much smaller than antibodies, so they might be better at penetrating tum
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Researchers decode genetics of rare photosynthetic bacterium
2. Researchers decode genetics of rare photosynthetic bacteria
3. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
4. Synthetic compound promotes death of lung-cancer cells, tumors
5. Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues
6. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
7. New book presents methods to poke and prod individual molecules
8. Curry-derived molecules might be too spicy for colorectal cancers
9. New molecules discovered that block cancer cells from modifying cell DNA
10. Clemson scientists shed light on molecules in living cells
11. Button mushrooms contain as much anti-oxidants as expensive ones

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
(Date:11/25/2009)...In addition to mammalian immune systems that besie...eriophages, viruses that kill half the bacteria on...other class of microorganisms called archaea (firs...sea volcanic vents) manage just fine, thank you, i... that helps protect them from many viruses and oth...
(Date:11/25/2009)...s recently received funding from the National Scie...al to understanding the environment. The three gra...istant professor in the Department of Biological S...e research projects. , His first project, titled...ctions from the Leaf to the Landscape," will exami...
(Date:11/24/2009)...ay help gut bacteria bind to the gastrointestinal ...ucers to identify strains that are likely to be of...teract with cells lining the gut to have a benefic...gut they are more likely to stick around long enou... from the Institute of Food Research. IFR is an I...
Breaking Biology News(10 mins):Researchers discover biological basis of 'bacterial immune system' 2Researchers discover biological basis of 'bacterial immune system' 3Kent State University professors focus research on the environment with grants totaling $890,000 2A sticky solution for identifying effective probiotics 2Refurbished and Used Industrial Parts Washers Grow in Popularity 51023 1Refurbished and Used Industrial Parts Washers Grow in Popularity 51023 2New York Law Firm Files Lawsuit Against Manufacturer of Zicam Nasal Spray and Drugstore Chain That Sold Product 51020 1New York Law Firm Files Lawsuit Against Manufacturer of Zicam Nasal Spray and Drugstore Chain That Sold Product 51020 2Report shows the power of US cities to mitigate climate change and steps they need to take to adapt 9157 1Report shows the power of US cities to mitigate climate change and steps they need to take to adapt 9157 2Report shows the power of US cities to mitigate climate change and steps they need to take to adapt 9157 3
...OLIS Discoveries by Indiana University School of ...o new drugs for toxoplasmosis and other parasites ...n the body. , Their findings help explain how the...o a cyst form that resists drugs and the body,s im... to strike when a patient,s immune system is weake...
...for National Pollinator Week, June 22 through June... compile a world checklist of bees. They have iden...2,000 more than previously estimated. There is a c... an unexplained phenomenon that is wiping out colo...his has highlighted the need for more information ...
... first Centre of Excellence for Public Health Rese...t today, with a focus on nutrition and lifestyle. ... to populations, the 5m centre is part of a 20 mil...e UK Clinical Research Collaboration (UKCRC). , I...ts in the wellbeing and health of the UK populatio...
Other Biology News:Indiana U scientists uncover potential key to better drugs to fight toxoplasmosis parasite 2New bee checklist lets scientists link important information about all bee species 2Queen's University launches UK's first Center of Excellence for Public Health 2
(Date:11/24/2009)...fficacy endpoint has been met for patients with ad..., QUEBEC CITY, Nov. 24 /PRNewswire-FirstCall/...) (the "Company"), a global biopharmaceutical comp...ay announced positive efficacy data from a Phase 2...te, AEZS-108 (formerly AN-152), in patients with a...
(Date:11/24/2009)...Nov. 24, 2009 Arena Phar...ay that the company is scheduled to present at the...on December 1, 2009 at 11:30 a.m. Eastern Time (8:... in New York City. Jack Lief, Arena,s President an... an overview of the company, including its clinica...
(Date:11/24/2009)...rogram Connects Customers with Partners Validated ...Genotek Products , Ottawa... leading provider of products for biological sampl... announced its new global partner program. The pro...ek,s partner community and is designed to help par...
(Date:11/23/2009)... 2009 In a provocative new study, a University of...emissions the major cause of global warming cann...ses or society builds the equivalent of one new nu...y that there will be any substantial near-term dep...on dioxide emission rates," says the new paper by ...
Breaking Biology Technology:AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 4Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 2Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 3DNA Genotek Launches Global Partner Program 2DNA Genotek Launches Global Partner Program 3Is global warming unstoppable? 2Is global warming unstoppable? 3Is global warming unstoppable? 4
...roduction , The distinctive luminescenc... the spectroscopist. Methods to counter the extrem...uantum yields have concentrated on , Pro...fects by XH moieties (X = O, N,). , , ...ffects of XH). , , , Antenn...
...operties of quantum dots (QDs) have potential appl...ing and biolabeling, memory devices, ...CdSeTe QDs are shown, herein to posse...pectra, correlated to size and compo... Spex FluoroMax spectrofluorometer. The QDs, ...
...roduction , The chemistry, spectroscopy,...considerable interest in environmental application...-oxygenation. 1 Recently, research has been direc...f 1 O 2 , such as the photodynamic destruction of.... <P,>An understanding of the mechanisms that pr...
Other Biology Technology:Time gated separation of lanthanide luminescence 2Photoluminescence Spectroscopy of Quantum Dots, monitored by the Spex FluoroMax 2Photoluminescence Spectroscopy of Quantum Dots, monitored by the Spex FluoroMax 3Photoluminescence Spectroscopy of Quantum Dots, monitored by the Spex FluoroMax 4Singlet Oxygen measurement 2
EGTA, Molecular Biology Grade from Research Organics, Inc.
EGTA, Molecular Biology Grade from Research Organics, Inc.
...and negatively supercoiled DNA in presence of EDTA...coiling on transcription in vitro , Studying chro...egree of supercoiling of naturally occurring DNA ...by only one base-pair , Increasing restriction en...
PARP Cleavage Immunoblotting Assay Kit from Upstate
Biology Products: