Navigation Links
Synthetic lethality: A new way to kill cancer cells
Date:2/22/2010

Ovarian and breast cancer treatments being developed that mix a protein inhibitor and traditional anticancer drugs are showing signs of success, according to a new review for Faculty of 1000 Biology Reports.

Susan Bates and Christina Annunziata looked at several recent papers on this form of treatment, which takes advantage of the synthetic lethality of BRCA (breast cancer susceptibility genes) and poly-ADP ribose polymerase (PARP) proteins to attack cancerous cells whilst sparing healthy ones.

BRCA and PARP are two key players in DNA repair and have different but complementary functions in the cell. Loss of the BRCA protein still allows the cell to survive but greatly increases its chances of becoming cancerous through the accumulation of mutations. The loss of both proteins, however, kills the cell in a process called synthetic lethality.

Researchers, by using drugs to block the activity of PARP in cells missing BRCA, such as those found in certain breast and ovarian cancers, can help spare healthy, non-cancerous cells because they have functional BRCA and are not affected by the loss of PARP. Thus, only cancer cells without functional BRCA protein are killed by drugs that inhibit PARP.

Recent clinical trials have shown that cancers caused by mutations that knock out BRCA activity can be controlled by blocking PARP activity with specific drugs. Patients were treated with traditional anticancer drugs alone or in combination with one of two new PARP inhibitors, olaparib or BSI-201.

Bates notes that patients on combination therapy had improved "[disease] progression-free survival, and overall survival" as compared to patients treated with traditional drugs alone.

Bates is optimistic about the promise of combining PARP inhibitors with existing cancer drugs. She says that the results of these clinical trials "have provided proof of principle in achieving synthetic lethality" with PARP-inhibiting drug
'/>"/>

Contact: Steve Pogonowski
press@f1000.com
Faculty of 1000: Biology and Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Biotech, nanotech and synthetic biology roles in future food supply explored
2. Synthetic protein mimics structure, function of metalloprotein in nature
3. Synthetic biology offers new opportunities for interdisciplinary collaboration
4. New synthetic molecules trigger immune response to HIV and prostate cancer
5. Sun or shade: Pecan leaves photosynthetic light response evaluated
6. Synthetic cells shed biological insights while delivering battery power
7. Understanding a cells split personality aids synthetic circuits
8. Nanotechnology and synthetic biology: What does the American public think?
9. Synthetic Biology Project receives 2 National Science Foundation grants
10. July 9-10 symposium on synthetic biology
11. Synthetic catalyst mimics natures hydrogen economy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic lethality: A new way to kill cancer cells
(Date:4/17/2014)... engineer has developed a patented technique that improves ... The same technique could help police during drug ... Kay L. Theede chair in engineering and department ... research team have created a template-based system that ... The distance detection method called stand-off bomb ...
(Date:4/17/2014)... is available in German . ... the protection money demanded of him, he can expect his ... however, as fear of the consequences is enough to make ... parasitic birds, which lay their eggs in other birds, nests. ... brood parasites take their revenge by destroying the entire nest. ...
(Date:4/17/2014)... many serious conditions such as heart disease, epilepsy and ... therapies. Unfortunately, there is still much scientists do not ... and unexpected insight into the structure of sodium channels ... - which are responsible for ,fine-tuning, the activity of ... recent edition of the Journal of Biological Chemistry ...
Breaking Biology News(10 mins):Patented research remotely detects nitrogen-rich explosives 2Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Structure of sodium channels different than previously believed 2
... American Association for the Advancement of Science (AAAS) will ... impact and contributions towards the production of African American ... associate dean of graduate studies and international programs in ... State University in Jackson, Miss., will receive his award ...
... NY (February 12, 2014) A team of Columbia ... Cardoso, MD, PhD, has found the first direct evidence ... postnatal airway hyperresponsiveness, a hallmark of asthma. The study, ... essential vitamin while the lung is forming can cause ...
... (Biological Impacts of Ocean Acidification) are developing a ... acidification and climate change with their economic and ... the Norwegian fishing industry and tourism sector, the ... key aspects for their assessment. During the ...
Cached Biology News:2013 AAAS Mentor Award goes to Paul B. Tchounwou of Jackson State University 22013 AAAS Mentor Award goes to Paul B. Tchounwou of Jackson State University 3Prenatal vitamin A deficiency tied to postnatal asthma 2Prenatal vitamin A deficiency tied to postnatal asthma 3Meeting the eye-witnesses of ocean change 2Meeting the eye-witnesses of ocean change 3
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
(Date:1/14/2014)... Boston, MA (PRWEB) January 14, 2014 iLab ... Michelle Detwiler as the new Director of Product Strategy. In ... as well as iLab sub-teams to guide in the development ... that iLab provides the maximum possible benefit to the scientific ...
(Date:1/14/2014)... 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology ... therapies addressing major unmet medical needs using RNA-targeted ... of Allowance from the United States Patent and ... (sd-rxRNA®), for the treatment of fibrosis. The patent ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... 9 /PRNewswire-FirstCall/ - Chromos Molecular,Systems Inc. ("Chromos" ... an,annual and special meeting held today, its ... (the "Arrangement") involving,among others, Chromos, Calyx Bio-Ventures ... Modatech Systems Inc. ("Modatech") under section,288 of ...
... the second consecutive,year, MedNet Solutions, a leading healthcare ... been recognized by,Inc. magazine as being among the ... growth over the past four years,MedNet was the ... area, and fifth among healthcare-related software companies in ...
... A seven and a half-year study,conducted in the In ... Health Network found that the use of ultraviolet C ... clinically significant,impact on clinical pregnancy rates (CPR). In presenting ... for Reproductive Medicine (ASRM),Kathryn C. Worrilow, Ph.D. reported that ...
Cached Biology Technology:Chromos announces shareholder approval of Arrangement 2Chromos announces shareholder approval of Arrangement 3MedNet Solutions Again Recognized as one of the Fastest Growing US Companies 2Germicidal UVC Lights Improve Clinical Pregnancy Rates for IVF Lab, New Study Finds 2
... and flexibility press-to-seal silicone isolators can be ... researcher. They are available either pre-cut to ... that can be easily trimmed to prepare ... non-cytotoxic and can be used to isolate ...
... Lacks the mycobacteria found in ... For this reason, Incomplete, Freund's ... Adjuvants may be used to produce water-in-oil emulsions ... stimulate high and long-lasting antibody responses which can ...
2,4-Dinitrophenyl hapten is conjugated to Keyhole Limpet (KLH) protein through lysine....
PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry....
Biology Products: