Navigation Links
Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies
Date:4/30/2013

A new use for compounds related in composition to the active ingredient in marijuana may be on the horizon: a new research report published in the Journal of Leukocyte Biology shows that compounds that stimulate the cannabinoid type 2 (CB2) receptor in white blood cells, specifically macrophages, appear to weaken HIV-1 infection. The CB2 receptor is the molecular link through which the pharmaceutical properties of cannabis are manifested. Diminishing HIV-1 infection in this manner might make current anti-viral therapies more effective and provide some protection against certain HIV-1 complications.

"The synthetic compounds we used in our study may show promise in helping the body fight HIV-1 infection,'" said Yuri Persidsky, M.D., Ph.D., a researcher involved in the work from the Department of Pathology and Laboratory Medicine at Temple University School of Medicine in Philadelphia, PA. "As compounds like these are improved further and made widely available, we will continue to explore their potential to fight other viral diseases that are notoriously difficult to treat."

To make this discovery, scientists used a cell culture model to infect human macrophages with HIV-1 and added synthetic compounds similar to the active ingredient in marijuana to activate the CB2 receptor. At different times during the infection, samples from the culture were taken to see if the replication of the HIV virus was decreased. The researchers observed diminished HIV growth and a possible protective effect from some HIV-1 complications.

"HIV/AIDS has posed one of the most significant health challenges in modern medicine," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Recent high profile vaccine failures mean that all options need to be on the table to prevent or treat this devastating infection. Research on the role of cannabinoid type 2 receptors and viral inf
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Predictability: The brass ring for synthetic biology
2. Synthetic molecule first electricity-making catalyst to use iron to split hydrogen gas
3. Synthetic Biologics to Present at the 2013 BIO CEO & Investor Conference
4. Developing microbial cell factories by employing synthetic small regulatory RNAs
5. Oscillating gel gives synthetic materials the ability to speak
6. Synthetic and biological nanoparticles combined to produce new metamaterials
7. New report finds increase in media coverage of synthetic biology
8. Synthetic fuel could eliminate US need for crude oil
9. Microchoreography: Researchers use synthetic molecule to guide cellular dance
10. Nottingham part of £20m investment for UK synthetic biology
11. Synthetic biofilter wins through to the top Sweet 16 in Boston
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... Dec. 2, 2014   Marvin Test Solutions ... test solutions for military, aerospace, and manufacturing organizations, ... its successful TS-900 PXI semiconductor test platform ... of high-end systems to customers at a fraction ... to traditional ATE. "Our semiconductor ...
(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014 Strict ... driver efficiency are piloting the North American and European ... of accidents growing, gesture recognition systems that are intuitive ... a mark in the industry. New ... Automotive Gesture Recognition Market in Europe ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... NVIDIA CUDA Teaching Centre in Canada. The ... electrical and computer engineering students how to tap ... units (GPU) and use them in computationally demanding ... that enables dramatic increases in computing performance for ...
... successful initial testing of a new form of methotrexate ... nose drops rather than injected. It shows promise as a ... appears in ACS, Molecular Pharmaceutics , a bi-monthly journal. ... is difficult to treat, partly because current anticancer drugs have ...
... major risk factor for disease, much of the threat ... a cluster of risk factors related to diabetes and ... many of these risk factors. However, many people struggle ... the University of Missouri have found that people who ...
Cached Biology News:McMaster, NVIDIA establish first CUDA Teaching Centre in Canada 2Putting on the pounds after weight loss? Hit the gym to maintain health gains 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... United Therapeutics Corporation (Nasdaq: UTHR ) announced today that it ... Wednesday, July 28, 2010 . , ... United Therapeutics will host a half-hour teleconference on Wednesday, ... teleconference is accessible by dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  A ...
... of the Chemical Engineering and Materials Science department ... Biology and Biomedical Engineering at Stevens Institute of ... their research entitled, "Evaporative Assembly of Drug-Eluting Bioresorbable ... of the pioneering work being undertaken by Professors ...
... - Dragon Pharmaceutical Inc. ("Dragon Pharma" or the "Company" TSX: ... Meeting of Shareholders held today, its shareholders, including those shareholders ... voted to approve the merger of Datong Investment Inc. with ... and Plan of Merger dated March 26, 2010 , ...
Cached Biology Technology:NSF funds infection-resistant orthopedic research 2Dragon Pharma shareholders approve merger and seek termination of listing on the OTCBB and TSX 2
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
... Shimadzus preparative LC/MS, using mass numbers as ... it ideal for performing investigation and research ... for both analytical and preparative operation. Switching ... in the software. This support provides a ...
... Label IT siRNA Tracker Intracellular Localization Kit ... label and deliver siRNA, of your design, ... in vitro tracking experiments. Subcellular localization and ... be monitored following introduction of the labeled ...
Selective media for Salmonella...
Biology Products: