Navigation Links
Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies
Date:4/30/2013

A new use for compounds related in composition to the active ingredient in marijuana may be on the horizon: a new research report published in the Journal of Leukocyte Biology shows that compounds that stimulate the cannabinoid type 2 (CB2) receptor in white blood cells, specifically macrophages, appear to weaken HIV-1 infection. The CB2 receptor is the molecular link through which the pharmaceutical properties of cannabis are manifested. Diminishing HIV-1 infection in this manner might make current anti-viral therapies more effective and provide some protection against certain HIV-1 complications.

"The synthetic compounds we used in our study may show promise in helping the body fight HIV-1 infection,'" said Yuri Persidsky, M.D., Ph.D., a researcher involved in the work from the Department of Pathology and Laboratory Medicine at Temple University School of Medicine in Philadelphia, PA. "As compounds like these are improved further and made widely available, we will continue to explore their potential to fight other viral diseases that are notoriously difficult to treat."

To make this discovery, scientists used a cell culture model to infect human macrophages with HIV-1 and added synthetic compounds similar to the active ingredient in marijuana to activate the CB2 receptor. At different times during the infection, samples from the culture were taken to see if the replication of the HIV virus was decreased. The researchers observed diminished HIV growth and a possible protective effect from some HIV-1 complications.

"HIV/AIDS has posed one of the most significant health challenges in modern medicine," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Recent high profile vaccine failures mean that all options need to be on the table to prevent or treat this devastating infection. Research on the role of cannabinoid type 2 receptors and viral inf
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Predictability: The brass ring for synthetic biology
2. Synthetic molecule first electricity-making catalyst to use iron to split hydrogen gas
3. Synthetic Biologics to Present at the 2013 BIO CEO & Investor Conference
4. Developing microbial cell factories by employing synthetic small regulatory RNAs
5. Oscillating gel gives synthetic materials the ability to speak
6. Synthetic and biological nanoparticles combined to produce new metamaterials
7. New report finds increase in media coverage of synthetic biology
8. Synthetic fuel could eliminate US need for crude oil
9. Microchoreography: Researchers use synthetic molecule to guide cellular dance
10. Nottingham part of £20m investment for UK synthetic biology
11. Synthetic biofilter wins through to the top Sweet 16 in Boston
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... evidence has demonstrated that transplantation of mesenchymal stem cells ... or mouse models of Alzheimer,s disease (AD) and improve ... ischemia. Few studies are reported on the therapeutic effect ... AD and on the effect on oxidative injury and ... Yan and her team, School of Life Sciences, Tsinghua ...
(Date:7/11/2014)... that cannabinoid receptor type 1 can inhibit ... and reduce neurotransmitter release. However, some scholars ... increase extracellular Ca2+ influx and increase neurotransmitter ... Tongji Hospital Affiliated to Tongji Medical College, ... used whole cell voltage-clamp and calcium imaging ...
(Date:7/11/2014)... brains of all vertebrates, information is transmitted through ... chemical signal to be passed from one brain ... most abundant type of synapse, can be either ... learning, memory, perception and cognition, and the balance ... function. For instance, every time we learn ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2
... May 3, 2010-Conventional agriculture production relies heavily on fossil ... a low cost. However, the uncertain future of fossil ... energy efficiencies in other cropping systems. Most of ... of corn and soybean with heavy inputs of fertilizer, ...
... May 3, 2010 Genes interact in complex networks that ... through relationships. Researchers are now discovering how biological networks ... published today in Genome Research ( www.genome.org ), ... shedding light on how interactions go awry in disease. ...
... May 2 Scientists at the University of Pittsburgh School ... a catch of new mediators that not only can explain ... novel treatments for a host of diseases linked to inflammatory ... of Nature Chemical Biology . There is strong ...
Cached Biology News:Reducing fossil energy use on the farm 2Reducing fossil energy use on the farm 3MicroRNA network study implicates rewired interactions in cancer 2Pitt pharmacologists go on a molecular fishing trip and hook prize catch 2
(Date:7/10/2014)... Los Angeles, CA (PRWEB) July 10, 2014 ... Analytical and Bioanalytical techniques during 18-20 August, 2014 at ... to critically review the recent developments in Analytical & ... across the globe. , Speaking on this occasion, Dr. ... that Analytica Acta conference is a remarkable one ...
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a firm ... today announced that it has acquired the Slim-Fast brand ... the business. Terms of the transaction were not disclosed. ... meal replacement business that markets ready-to-drink shakes, powders, bars ... America and in the United ...
(Date:7/10/2014)... help in the fight against terrorism with the creation ... explosives with the use of light and special glass ... Actuators B: Chemical , the researchers describe a novel ... as low as 6.3 ppm (parts per million). It ... , "Traditionally explosives detection has involved looking for metals ...
(Date:7/10/2014)... batteries that power our laptops and electric vehicles could ... charge with the help of a sponge-like silicon material. ... the graphite traditionally used in one of the battery,s ... energy storage capacity of graphite. A paper describing the ... today in Nature Communications . , "Silicon has ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... the diuretic hydrochlorothiazide (HCTZ) in ... in significant additional blood pressure reductions compared to either drug alone ... or more, medicines - single-tablet combinations simplify treatment by reducing ... number of pills patients take, EAST ...
... Named ,Illinois Rising Stars, CHICAGO, Jan. 18 ... property law firms in the United States, is,pleased to ... "Illinois,Super Lawyers" for 2008 in a survey conducted by ... designated "Rising Stars" in,Illinois., Meredith Martin Addy, chair ...
... Jan. 18 Abbott (NYSE: ABT ),announced today ... for its fully automated HTLV-I/HTLV-II blood screening test,for use ... for use by,laboratories to screen individual donations of blood ... Type I and/or human T --,lymphotropic virus Type II ...
Cached Biology Technology:Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 2Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 3Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 4Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 5Twenty-One Brinks Hofer Gilson & Lione Attorneys Named 2008 'Illinois Super Lawyers' 2Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV-I/HTLV-II 2Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV-I/HTLV-II 3