Navigation Links
Synthetic compound promotes death of lung-cancer cells, tumors
Date:11/12/2007

DALLAS Nov. 12, 2007 Human lung-cancer tumors grown in mice have been shown to regress or disappear when treated with a synthetic compound that mimics the action of a naturally occurring death-promoting protein found in cells, researchers at UT Southwestern Medical Center report.

The findings, appearing in todays issue of Cancer Cell, suggest that the compound might one day be used in targeted therapies for lung and possibly other cancers, the researchers said.

We found that certain kinds of lung-cancer cells were sensitive to this compound, which sends a signal to cancer cells to self-destruct, said Dr. Xiaodong Wang, professor of biochemistry at UT Southwestern and senior author of the study.

In 2000, Dr. Wang announced the discovery of a cellular protein called Smac, which plays a key role in the normal self-destruction apparatus present in every cell. This process, called apoptosis, is activated when a cell needs to be terminated, such as when a cell is defective or becomes unnecessary during normal growth and development. In cancer cells, the self-destruct mechanism is faulty.

In 2004, Dr. Wang and his colleagues developed a compound that mimics the action of Smac. They found that in cell cultures, the compound killed cancer cells but left healthy cells unaffected. In those studies, however, the Smac mimic only killed cancer cells when it was introduced along with another molecule often involved in the cell-death machinery, called tumor necrosis factor-a, or TNFa.

In the current study, Dr. Wangs research group tested 50 human non-small-cell lung-cancer cell lines in culture and found that 22 percent of them were sensitive to the Smac mimic alone, without having to add TNFa. The researchers also found that the Smac mimic alone was effective against some types of breast cancer and melanoma cells in culture.

The apparent ability of a Smac mimetic, as a single agent, to induce cell death in n
'/>"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center  
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues
2. New microsensor measures volatile organic compounds in water and air on-site
3. Naturally-occurring apple compounds reduce risk of pancreatic cancer
4. Chemical compound present in detergents produce bacteria alterations in agricultural soils
5. Bleeding, not inflammation, is major cause of early lung infection death
6. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
7. Scientists find how amber becomes death trap for watery creatures
8. MIT develops tractor beam for cells, more
9. Invasion of the brain tumors
10. Analysis of breast and colon cancer genes finds many areas of differences between tumors
11. Cell response to stress signals predicts tumors in women with common pre-breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthetic compound promotes death of lung-cancer cells, tumors
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... in Panama to use genetic barcoding, scientists at the ... 20 sand fly species from Barro Colorado Island. Two ... causes cutaneous leishmaniasis: persistent, itchy skin lesions. Three species ... that could contribute to a strategy to control the ...
... April 6, 2010 -- Spectacularly increased yields and improved ... researchers at the Robert H. Smith Faculty of Agriculture, ... Cold Spring Harbor Laboratory (CSHL), New York. The ... gene, which controls when plants make flowers and that ...
... scientists from around the world are involved in a ... research on the increasingly fragile relationship between humans and ... research as a priority and has selected MSU to ... on Coupled Human and Natural Systems, or CHANS-Net. The ...
Cached Biology News:Sand fly barcoding in Panama reveals Leishmania strain and its potential control 2Genetic key discovered to dramatically increase yields and improve taste of hybrid tomato plants 2Genetic key discovered to dramatically increase yields and improve taste of hybrid tomato plants 3MSU leads global effort to study link between people, planet 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... , Three-of-Four Patients Surveyed Experience Daily Pain From ... the European League Against Rheumatism Annual Congress of ... Results from the Rheumatoid Arthritis: Insights, Strategies ... rheumatoid arthritis (RA) patients throughout Europe and Canada ...
... SPRINGFIELD, Va., June 9 Methuselah Foundation has identified ... of bio-printing. The US Department of Health and ... be the standard of care for replacing all tissue/organ ... Methuselah Foundation, is applying its breakthrough organ printing technologies ...
... and Patient Reported Outcome Strategies , , PITTSBURGH, ... leader in electronic patient reported outcomes (ePRO) solutions and ... ePROficiency(TM) Web seminar series on Patient Reported Outcomes (PRO). ... a continuation of invivodata,s educational initiative which focuses on ...
Cached Biology Technology:New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 2New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 3New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 4New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 5New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 6Printing New Organs: Foundation Funds Medical Technology That Replicates Human Tissue 2invivodata Announces ePROficiency 2009 Web Seminar Series 2