Navigation Links
Synthetic collagen from maize has human properties
Date:6/23/2011

Synthetic collagen has a wide range of applications in reconstructive and cosmetic surgery and in the food industry. For proper function in animals a certain number of prolines within the protein need to be hydroxylated. BioMed Central's open access journal BMC Biotechnology reports that for the first time the α1 chain of type 1 collagen has been produced in maize with similar levels of proline hydroxylation to human collagen.

Most collagen used is derived from animals but there are risks associated with this collagen containing infectious agents or being rejected by the body. To avoid this problem several laboratorybased systems have been developed using plants to produce collagen. Plant-derived recombinant proteins should have lower contamination and fewer infectious agents, but these systems are unable to make modifications to the protein essential for proper function in human cells.

Working in collaboration with industrial partners researchers added a gene, which codes for the α1 chain of human CI (hCI α1), to maize along with genes which make human prolyl 4-hydroxylase. This second protein was able to hydroxylate approximately the same percentage of prolines in the recombinant collagen α1 chain, produced in maize, as seen for human collagen made in human cells.

Dr Kan Wang from Iowa State University said, "Producing human collagen in maize seeds is an inexpensive alternative to using animal-derived collagen. The seeds are easy to grow, process, and store. Our transgenic plant system is also able to produce a protein with human-like modifications making it a better choice for a wide range of applications."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
2. Biological circuits for synthetic biology
3. UC Berkeley launches Synthetic Biology Institute to advance research in biological engineering
4. Open-source software designed to minimize synthetic biology risks
5. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
6. Chicken litter provides organic alternative to synthetic fertilizers
7. Vaccine made with synthetic gene protects against deadly pneumonia
8. Research into synthetic antibodies offers hope for new diagnostics
9. Scripps Research team creates new synthetic compound with HIV-fighting promise
10. Princeton scientists construct synthetic proteins that sustain life
11. Bioethics Commission calls for enhanced federal oversight in new field of synthetic biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
(Date:3/13/2017)... , March 13, 2017 Future of security: Biometric ... ... DERMALOGs Face Matching enables to match face pictures ... the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face ...
(Date:3/7/2017)... March 7, 2017   HireVue , the leading ... companies identify the best talent, faster, today announced the ... Officer (CSO) and Diana Kucer as Chief ... seasoned executive team poised to drive continued growth in ... a year of record bookings in 2017. ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... Open Therapeutics and the ... sharing and commercialization model. , The Center for Advancing Innovation helps institutions maximize ... effort is bringing the IP to the attention of the entrepreneurial community and ...
(Date:4/20/2017)... N.J. and PETACH TIKVAH, Israel ... BCLI), a leading developer of adult stem cell technologies for ... Executive Officer, will present at the Alliance for Regenerative Medicine,s ... Day on Thursday, April 27, 2017 at 09:40 EDT in ... Ralph Kern , MD, MHSc, Chief Medical Officer & ...
(Date:4/19/2017)... ... April 18, 2017 , ... The ... a key device for generating monodisperse droplets of known diameters for research applications ... generating monodisperse solid particles by drying monodisperse droplets. , The VOAG requires ...
(Date:4/19/2017)... (PRWEB) , ... April 18, 2017 , ... Alisa Wright, ... Distinguished Alumni Awards from the Purdue College of Pharmacy in Lafayette, Indiana. , ... Pharmacy Program for achievements in their careers and other scientific endeavors. , Wright ...
Breaking Biology Technology: