Navigation Links
Synthetic collagen from maize has human properties
Date:6/23/2011

Synthetic collagen has a wide range of applications in reconstructive and cosmetic surgery and in the food industry. For proper function in animals a certain number of prolines within the protein need to be hydroxylated. BioMed Central's open access journal BMC Biotechnology reports that for the first time the α1 chain of type 1 collagen has been produced in maize with similar levels of proline hydroxylation to human collagen.

Most collagen used is derived from animals but there are risks associated with this collagen containing infectious agents or being rejected by the body. To avoid this problem several laboratorybased systems have been developed using plants to produce collagen. Plant-derived recombinant proteins should have lower contamination and fewer infectious agents, but these systems are unable to make modifications to the protein essential for proper function in human cells.

Working in collaboration with industrial partners researchers added a gene, which codes for the α1 chain of human CI (hCI α1), to maize along with genes which make human prolyl 4-hydroxylase. This second protein was able to hydroxylate approximately the same percentage of prolines in the recombinant collagen α1 chain, produced in maize, as seen for human collagen made in human cells.

Dr Kan Wang from Iowa State University said, "Producing human collagen in maize seeds is an inexpensive alternative to using animal-derived collagen. The seeds are easy to grow, process, and store. Our transgenic plant system is also able to produce a protein with human-like modifications making it a better choice for a wide range of applications."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
2. Biological circuits for synthetic biology
3. UC Berkeley launches Synthetic Biology Institute to advance research in biological engineering
4. Open-source software designed to minimize synthetic biology risks
5. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
6. Chicken litter provides organic alternative to synthetic fertilizers
7. Vaccine made with synthetic gene protects against deadly pneumonia
8. Research into synthetic antibodies offers hope for new diagnostics
9. Scripps Research team creates new synthetic compound with HIV-fighting promise
10. Princeton scientists construct synthetic proteins that sustain life
11. Bioethics Commission calls for enhanced federal oversight in new field of synthetic biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... -- Newest Market IPO,s and exchange ... significant investor attention with news concerning shareholder updates and new ... NXT-ID, Inc. (NASDAQ: NXTD ), Alibaba Group Holding ... MBLY ), GoPro, Inc. (NASDAQ: GPRO ) ... (NASDAQ: NXTD ) recently completed an essential round ...
(Date:9/23/2014)... parasitic DNA fragments called "jumping genes" that insert themselves ... And that phenomenon can result in age-related diseases such ... now report that the "jumping genes" in mice become ... stops keeping them in check in order to take ... today in Nature Communications , Professor of Biology ...
(Date:9/22/2014)... September 23, 2014 A new American Cancer Society ... Assistance Program (SNAP), previously known as the food ... with income eligible non-participants. The authors say the ... at enhancing the dietary quality of SNAP participants. ... individuals and households with the resources to obtain ...
Breaking Biology News(10 mins):Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 2Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 3Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 4Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 5Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 6Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 7A multi-function protein is key to stopping genomic parasites from 'jumping' 2Federal food program puts food on the table, but dietary quality could be improved 2
... Calif., June 6 Communication,Intelligence Corporation (the "Company") ... signature solutions for business process,automation in the financial ... announced today that it has closed a financing, ... LLC (the "Investor")., As part of the ...
... basic questions about how life originated and has ... Foundation,s (NSF) Division of Environmental Biology (DEB). Ranging ... NSF,s awards for these studies will help resolve ... responses to environmental changes, including climate change. ...
... it was black as night. It was May 19, 1780 ... at hand. Accounts of that day, which became known as ... candlelight, night birds coming out to sing, flowers folding their ... has been solved by researchers at the University of Missouri ...
Cached Biology News:Communication Intelligence Corporation Closes $3.6 Million Financing 2Communication Intelligence Corporation Closes $3.6 Million Financing 3Communication Intelligence Corporation Closes $3.6 Million Financing 4National Science Foundation funds research addressing enduring questions of life 2National Science Foundation funds research addressing enduring questions of life 3National Science Foundation funds research addressing enduring questions of life 4Mystery of infamous 'New England Dark Day' solved by 3 rings 2
(Date:9/23/2014)... 23, 2014 Dr. Williams says, “Find ... on healthcare offers a three phase process that can ... delivery system that would go far beyond anything previously ... the delivery of healthcare.” , “Every effort to improve ... to provide discernable progress throughout that system because all ...
(Date:9/23/2014)... 23, 2014 New spin-out ... Innovations, Cambridge Innovation Capital and Johnson & Johnson ... genomics company focused on harnessing the potential of ... testing and treatment, today announced it has raised ... Innovations and including Cambridge Innovation Capital and Johnson ...
(Date:9/22/2014)... SANTA CLARA, Calif. , Sept. 22, ... WBMD ), the leading source of health information, today ... that provide novel insights regarding physician and patient ... care.  Dr. Eric Topol , a leading authority ... serves as both Editor-in-Chief of Medscape and Chief Academic ...
(Date:9/22/2014)... cell fragments whose job it is to stop bleeding, ... But they can "feel" the physical environment around them, ... Platelets respond to surfaces with greater stiffness by increasing ... other platelets and other components of the clotting system, ... give them credit for, in that they are able ...
Breaking Biology Technology:Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 3Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 4WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 4Platelets modulate clotting behavior by 'feeling' their surroundings 2
... Genetic Test Provides Early Diagnosis of Mitochondrial Diseases ... MEDomics, LLC ( www.medomics.com ) announces ... diseases, a group of disorders that can result ... headaches, blindness, deafness, and diabetes. The MEDomics mitochondrial ...
... Caliper Life Sciences, Inc. (Nasdaq: CALP ) today ... House entitled, "Innovation for Experimentation" to be held June 17, ... the Investor Breakout Session from 2:30 - 4:00 p.m. EDT. ... feature presentations by Kevin Hrusovsky, President and CEO, as well ...
... N.J., June 8 A study in ... , published by Elsevier, demonstrates that the Hepascore(TM) liver ... diagnose and stage liver fibrosis in patients with chronic ... biopsy, the standard of care for staging fibrosis, in ...
Cached Biology Technology:MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test 2MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test 3Caliper Life Sciences to Webcast Investor Session of Open House 2Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C 2Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C 3Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C 4
... application capable of dynamic scheduling, is designed ... lab automation workcells easy for lab personnel, ... programmers. • Users create methods ... you can build a flowchart, you can ...
... research demands continue to grow, the need ... information has become necessary, especially when discerning ... The innovative C1si Confocal Microscope System gives ... spectral capability not available in conventional confocal ...
... kit provides complete components including positive ... detection of DNA fragmentation in cultured ... of BrdU in the procedure provides ... methods. Results can be analyzed by ...
... Whatever your Ion Chromatography requirements, IonQuest ... The newly developed conductivity detector has ... drift . In addition to the ... used with other detectors, such as electrochemical, ...
Biology Products: