Navigation Links
Synthetic collagen from maize has human properties
Date:6/23/2011

Synthetic collagen has a wide range of applications in reconstructive and cosmetic surgery and in the food industry. For proper function in animals a certain number of prolines within the protein need to be hydroxylated. BioMed Central's open access journal BMC Biotechnology reports that for the first time the α1 chain of type 1 collagen has been produced in maize with similar levels of proline hydroxylation to human collagen.

Most collagen used is derived from animals but there are risks associated with this collagen containing infectious agents or being rejected by the body. To avoid this problem several laboratorybased systems have been developed using plants to produce collagen. Plant-derived recombinant proteins should have lower contamination and fewer infectious agents, but these systems are unable to make modifications to the protein essential for proper function in human cells.

Working in collaboration with industrial partners researchers added a gene, which codes for the α1 chain of human CI (hCI α1), to maize along with genes which make human prolyl 4-hydroxylase. This second protein was able to hydroxylate approximately the same percentage of prolines in the recombinant collagen α1 chain, produced in maize, as seen for human collagen made in human cells.

Dr Kan Wang from Iowa State University said, "Producing human collagen in maize seeds is an inexpensive alternative to using animal-derived collagen. The seeds are easy to grow, process, and store. Our transgenic plant system is also able to produce a protein with human-like modifications making it a better choice for a wide range of applications."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

0

GOOD

Page: 1

Related biology news :

1. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
2. Biological circuits for synthetic biology
3. UC Berkeley launches Synthetic Biology Institute to advance research in biological engineering
4. Open-source software designed to minimize synthetic biology risks
5. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
6. Chicken litter provides organic alternative to synthetic fertilizers
7. Vaccine made with synthetic gene protects against deadly pneumonia
8. Research into synthetic antibodies offers hope for new diagnostics
9. Scripps Research team creates new synthetic compound with HIV-fighting promise
10. Princeton scientists construct synthetic proteins that sustain life
11. Bioethics Commission calls for enhanced federal oversight in new field of synthetic biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... a class of pharmaceuticals can both prevent and treat ... as "TSPO ligands," are currently used for certain types ... TSPO ligand in young adult mice when pathology was ... pathology was quite severe," said lead researcher Christian Pike ... reduced measures of pathology and improved behavior at both ...
(Date:5/21/2013)... Mo. Cancers of all types become most deadly ... Once cancer has reached this stage, it becomes very ... tumors that can develop. Now, researchers at the University ... nanoparticles that target lymphoma tumor cells wherever they may ... of oncology in the MU College of Veterinary Medicine, ...
(Date:5/21/2013)... stores, phosphatidylserine is a natural food supplement produced ... cognition and slow memory loss, it,s a popular ... a team headed by Prof. Gil Ast and ... of Human Molecular Genetics have discovered ... genes involved in degenerative brain disorders, including Parkinson,s ...
Breaking Biology News(10 mins):Drugs found to both prevent and treat Alzheimer's disease in mice 2MU researchers develop radioactive nanoparticles that target cancer cells 2Common food supplement fights degenerative brain disorders 2
... iris recognition and DNA databases, but researchers in India ... allow law enforcement agencies and airport security to recognize ... gait. The team reveals details of a comprehensive framework ... of the Inderscience publication, the International Journal of ...
... same time impact the delivery of drugs and explain ... synthetic nanoparticles that can penetrate a cell without poking ... The key to their approach? Stripes. The ... of two different kinds of molecules can quickly pass ...
... The appointment of James Watson as Director ... an explosive development of research at Cold Spring Harbor ... of investigators with diverse scientific interests. In a ... scientists involved tell the stories of research carried out ...
Cached Biology News:Tell me by the way I walk 2MIT: Stripes key to nanoparticle drug delivery 2Watson-inspired innovation in research at Cold Spring Harbor Laboratory 2
(Date:5/21/2013)... Through science fairs, workshops, kits for building optical ... organizations will continue their work to increase awareness about ... daily life with the aid of SPIE Education ... countries, are the first of two groups of recipients ... international society for optics and photonics , in 2013. ...
(Date:5/21/2013)... Raleigh, NC (PRWEB) May 21, 2013 ... and financial services company for clinical trials, announced ... Aggregate Spend Solutions, LLC. Clinverse’s ClinPay® FLS ... automated investigator payment process. SpendMD ™, ... only complete solution for tracking and reporting transfer ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Emerson ... announced that Dr. Charles Signorino, the Company’s Chief Executive ... 1, 2013 after 32 years of service. As part ... Emerson’s current President, has been named as Dr. Signorino’s ... in the pharmaceutical industry, having made a significant contribution ...
(Date:5/21/2013)... MN (PRWEB) May 21, 2013 Revolutionary ... patented automatic colony counter, announced today that they have ... products , the IncuCount, IntelliCount, InCount and ImpressCount. ... and sophistication are especially useful in food microbiology and ... given an updated look. A bright white enclosure ...
Breaking Biology Technology:Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 2Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 3Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3Emerson Resources Announces CEO Retirement and Appointment of Successor 2Emerson Resources Announces CEO Retirement and Appointment of Successor 3Revolutionary Science Announces New Automatic and Manual Colony Counting Products 2
... New research suggests that some patients develop a potentially ... bacterial cells in their bodies have gene mutations that ... with implants can develop infections because of a biofilm ... devices. Researchers found that some strains of the bacteria, ...
... electronic and mechanical effects occurring in devices and ... are being investigated by researchers around the world. ... the generation of light, optical sensing, and information ... in physics and applications in this area, the ...
... (Nasdaq: CELG: $68) has been picked by S&P Capital ... carries S&P Capital IQ,s highest investment recommendation of 5-STARS, ... be among the best positioned biotechs for long-term growth, ... Equity Analyst at S&P Capital IQ.  "We believe the ...
Cached Biology Technology:Study offers clues as to why some patients get infections from cardiac implants 2Study offers clues as to why some patients get infections from cardiac implants 3Study offers clues as to why some patients get infections from cardiac implants 4Study offers clues as to why some patients get infections from cardiac implants 5Optics Express Focus Issue: Collective phenomena in photonic, plasmonic and hybrid structures 2Optics Express Focus Issue: Collective phenomena in photonic, plasmonic and hybrid structures 3Optics Express Focus Issue: Collective phenomena in photonic, plasmonic and hybrid structures 4Optics Express Focus Issue: Collective phenomena in photonic, plasmonic and hybrid structures 5S&P Capital IQ Picks Celgene Focus Stock of the Week 2S&P Capital IQ Picks Celgene Focus Stock of the Week 3
Rabbit polyclonal to FANCG ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSRQTTSVGSSC, corresponding to amino acids 1 - 12 of Human FANCG. Entrez GeneID: 2189 Swis...
Rabbit polyclonal to DcR2 ( Abpromise for all tested applications). entrezGeneID: 8793 SwissProtID: Q9UBN6...
...
...
Biology Products: