Navigation Links
Synthetic bone graft recruits stem cells for faster bone healing
Date:8/2/2010

Scientists have developed a material for bone grafts that could one day replace the 'gold standard' natural bone implants.

A new study shows how particles of a ceramic called calcium phosphate have the ability to stimulate promising bone regrowth by attracting stem cells and 'growth factors' to promote healing and the integration of the grafted tissue.

"The rate of bone repair we see with these materials rivals that of traditional grafts using a patients' own bone," said Professor Joost de Bruijn from the School of Engineering and Materials Science at Queen Mary, University of London. "And what sets it apart from other synthetic graft substitutes is its ability to attract stem cells and the body's natural growth factors, which coincide to form new, strong, natural bone around an artificial graft."

The researchers tested natural bone grafts against ceramic particles with varied structural and chemical properties. They found that micro-porous ceramic particles composed of calcium phosphate, the primary component of bone ash, induced stem cells to develop into bone cells in the test tube and stimulated bone growth in live tissue in mice, dogs and sheep.

Bone injuries packed with the ceramic particles healed similarly to implants constructed from the animals' own bone, reports Professor de Bruijn along with collaborators from the University of Twente, Netherlands, in the journal Proceedings of the National Academy of Sciences. The study also shows how it also matches a commercially available product that contains artificial growth factors and has the undesirable side-effect of causing bone fragments to form in nearby soft tissue, such as muscle.

Although the researchers have not yet identified the mechanism that drives bone growth in the synthetic implants, they note that variations in the ceramic material's chemistry, micro-porosity, micro-structure, and degradation influence the graft's performance.

The study suggests that biomaterials-based bone grafts can manipulate cell behaviour in order to repair injury, and one day may be used to repair bone injuries in humans.


'/>"/>

Contact: Simon Levey
s.levey@qmul.ac.uk
44-207-822-7454
Queen Mary, University of London
Source:Eurekalert

Related biology news :

1. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
2. Synthetic Biology: Coming Up Fast!
3. Biosynthetics production with detours
4. UNC scientists teach enzyme to make synthetic heparin in more varieties
5. Synthetic virus supports a bat origin for SARS
6. Synthetic biology: Is ethics a showstopper?
7. Synthetic biology key in the 21st century
8. Milestone achieved toward production of malaria treatment using synthetic biology and fermentation
9. Synthetic biology can help extend anti-malaria drug effectiveness
10. Orientation of antenna protein in photosynthetic bacteria described
11. Using combinatorial libraries to engineer genetic circuits advances synthetic biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... , March 30, 2017 The research ... system for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D ... a new realm of speed and accuracy for use in identification, ... an affordable cost. ... ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/9/2017)... ... , ... The award-winning American Farmer television series will feature 3 Bar Biologics ... at 8:30aET on RFD-TV. , With global population estimates nearing ten billion people ... to feed a growing nation. At the same time, many of our valuable resources ...
Breaking Biology Technology: