Navigation Links
Synthesizing the most natural of all skin creams
Date:3/17/2009

Even after nine months soaking in the womb, a newborn's skin is smooth unlike an adult's in the bath. While occupying a watery, warm environment, the newborn manages to develop a skin fully equipped to protect it in a cold, dry and bacteria-infected world. A protective cream called Vernix caseosa (VC), which covers the fetus and the newborn, aids in the growth of skin both before and after birth. VC provides 'waterproofing' in utero, allowing skin to grow in wet conditions, while after birth it hydrates and cleanses, even healing when applied to ulcers. Prof. Joke Bouwstra, a specialist in the skin barrier and its synthesis at Leiden University, and her colleague Robert Rimann set out to study VC in detail and has produced a synthetic version of this natural buttery ointment which shows the same structure and unique properties. As well as helping pre-term babies develop essential protection against temperature changes, dehydration and infection, artificial VC could also benefit sufferers of skin disease.

Like most moisturising creams, VC is mostly water. Its outstanding properties come from the addition of just 10% each of lipid molecules and dead skin cells (corneocytes), so the exact composition of the mixture is important.

For the lipids, X-ray diffraction measurements at the Dutch/Flemish DUBBLE beamline at the ESRF (European Synchrotron Radiation Facility) allowed the Leiden researchers to find the proportions of the various forms in the cream, even distinguishing between complex molecules differing in chain length.

The corneocytes were also studied using electron microscopy, yielding their size, shape and water content.

But equally important is how the mixture arranges itself. Lipid molecules are shaped something like lollipops, with a round end that prefers to be surrounded by water and a stick which prefers to make a raft with other lollipop sticks. VC contains several different lengths of lipids, which form different arrangements as the temperature changes. The result is that VC fulfils different functions inside and outside the womb, just as butter behaves differently in the oven and on the table. Again, the ESRF's synchrotron light was used to illuminate the corneocytes and lipids together and look for any clumps or other ordering. Once they knew exactly what VC was made of and how it was arranged, they set about creating a synthetic version.

A readily available natural source of the sort of fat molecules needed is lanolin, the oil found in sheep's wool, which is currently used as a skin treatment by some nursing mothers. The team isolated the fats which were the closest match to the measurements they had of VC, and used them to create a synthetic solution with the same behaviour. The corneocytes were synthesized by M.H.M. Oudshoorn from the Utrecht University. When combined, these synthetic ingredients made a cream which looked the same using both x-ray measurements and light microscopy as VC, while allowing the researchers to alter the water content and other properties at will. After pre-clinical testing, the developed creams showed great potential for use on disrupted and underdeveloped skin: the skin barrier recovered much more quickly when synthetic VC was applied. These promising results will give rise to future clinical studies, in order to prove the benefits of the newly developed creams in treating healthy, dry and diseased human skin.


'/>"/>

Contact: Montserrat Capellas
capellas@esrf.fr
33-476-882-663
European Synchrotron Radiation Facility
Source:Eurekalert  

Related biology news :

1. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
2. Photosynthesizing bacteria with a day-night cycle contain rare chromosome
3. A natural approach for HIV vaccine
4. Understanding natural crop defenses
5. Honest crabs, power to the hungry, nice mice and clever meerkats: News from the American Naturalist
6. A natural, alternative insect repellent to DEET
7. Even natural perfumes may cause allergies
8. Ocean islands fuel productivity and carbon sequestration through natural iron fertilization
9. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
10. As super-predators, humans reshape their prey at super-natural speeds
11. Particulate emission from natural gas burning home appliances
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Synthesizing the most natural of all skin creams
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
Breaking Biology Technology: