Navigation Links
Synaptic levels of clathrin protein are important for neuronal plasticity
Date:6/19/2014

Researchers of the group of cellular and molecular neurobiology of the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona, led by researcher Artur Llobet, have shown that synaptic levels of the protein clathrin are a determinant factor for synaptic plasticity of neurons.

Chemical synapses and synaptic vesicular transmission cycle

Neurons transmit information in a specialized contact points called synapses. These structures consist of two elements: the presynaptic one, information donor, and postsynaptic, which receives the information. In the case of the presynaptic terminal, information is stored in vesicles containing neurotransmitters. When a stimulus arrives at the presynaptic terminal releases a vesicle by exocytosis. But to prevent the terminal to run out vesicles, immediately after exocytosis, occurs endocytosis. This coupling between exo and endocytosis defines what is known as vesicular synaptic vesicle cycle and is essential for neurons to release information correctly.

The vesicular cycle must adapt to constant changes in neuronal activity, and thus is a determinant of neuronal plasticity.

The dogma of the clathrin

Study investigators have sought to determine the role of clathrin in synaptic plasticity. "This protein is involved in all processes of endocytosis in all cells of the body and until now it was thought that it presents as abundant levels that it wouldn't pose a limiting factor" explained Artur Llobet.

"Our study," adds the researcher "questions this dogma because we found that in periods of intense neuronal stimulation, but within physiological levels, presynaptic levels of clathrin decrease reversibly. Ie levels clathrin are a dynamic property of the terminals".

"This is not surprising, what it is, is that a drop of only 20% are able to alter synaptic function. Specifically, this reduction reduces the number of vesicles that can be released, which has a direct action on exocytosis and therefore on the release of information. "

"In short," said Llobet "we showed that clathrin levels are a limiting factor for synaptic transmission, thus contributes to synaptic plasticity." Article's reference


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Synaptics to Showcase Industry-Leading Human Interface Solutions At 2014 Consumer Electronics Show
2. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
3. Carnegie Mellon neuroscientists discover new phase of synaptic development
4. Bionic pancreas controls blood sugar levels in adults, adolescents with type 1 diabetes
5. Fasting reduces cholesterol levels in prediabetic people over extended period of time
6. Study confirms how the body regulates high levels of CO2 in the blood
7. Children with autism have elevated levels of steroid hormones in the womb
8. Subtle change in DNA, protein levels determines blond or brunette tresses, study finds
9. New research shows humans have more impact on tropical nitrogen levels
10. How have changing sea-levels influenced evolution on the Galapagos Islands?
11. Elevated liver enzyme levels linked to higher gestational diabetes risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... Calif. , April 18, 2017  Socionext Inc., a global ... of a media edge server, the M820, which features the company,s ... recognition software provided by Tera Probe, Inc., will be showcased during ... at the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... , ... August 11, 2017 , ... A staple in ... this month that will incorporate important key elements including a new digital marketing strategy ... that has supported them, Bill Miller has partnered with the South Texas Blood & ...
(Date:8/10/2017)... ... August 09, 2017 , ... Teachers from ... students. From August 14th through the 16th, the University City Science Center will ... summer of 2016, provides Philadelphia-based middle school educators an opportunity for professional development ...
(Date:8/10/2017)... USA (PRWEB) , ... August 09, 2017 , ... ... partnered with four international biomedical optics laboratories — the Wellman Center for Photomedicine, ... Medical Laser Center Lübeck and the Beckman Laser Institute at University of California, ...
(Date:8/10/2017)... ... August 10, 2017 , ... BellBrook Labs announces the ... , an enabling new high throughput screening (HTS) assay to aid researchers in ... debilitating diseases. , Chemical modification of gene expression, also known as epigenetics, is ...
Breaking Biology Technology: