Navigation Links
Synaptic levels of clathrin protein are important for neuronal plasticity

Researchers of the group of cellular and molecular neurobiology of the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona, led by researcher Artur Llobet, have shown that synaptic levels of the protein clathrin are a determinant factor for synaptic plasticity of neurons.

Chemical synapses and synaptic vesicular transmission cycle

Neurons transmit information in a specialized contact points called synapses. These structures consist of two elements: the presynaptic one, information donor, and postsynaptic, which receives the information. In the case of the presynaptic terminal, information is stored in vesicles containing neurotransmitters. When a stimulus arrives at the presynaptic terminal releases a vesicle by exocytosis. But to prevent the terminal to run out vesicles, immediately after exocytosis, occurs endocytosis. This coupling between exo and endocytosis defines what is known as vesicular synaptic vesicle cycle and is essential for neurons to release information correctly.

The vesicular cycle must adapt to constant changes in neuronal activity, and thus is a determinant of neuronal plasticity.

The dogma of the clathrin

Study investigators have sought to determine the role of clathrin in synaptic plasticity. "This protein is involved in all processes of endocytosis in all cells of the body and until now it was thought that it presents as abundant levels that it wouldn't pose a limiting factor" explained Artur Llobet.

"Our study," adds the researcher "questions this dogma because we found that in periods of intense neuronal stimulation, but within physiological levels, presynaptic levels of clathrin decrease reversibly. Ie levels clathrin are a dynamic property of the terminals".

"This is not surprising, what it is, is that a drop of only 20% are able to alter synaptic function. Specifically, this reduction reduces the number of vesicles that can be released, which has a direct action on exocytosis and therefore on the release of information. "

"In short," said Llobet "we showed that clathrin levels are a limiting factor for synaptic transmission, thus contributes to synaptic plasticity." Article's reference


Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Related biology news :

1. Synaptics to Showcase Industry-Leading Human Interface Solutions At 2014 Consumer Electronics Show
2. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
3. Carnegie Mellon neuroscientists discover new phase of synaptic development
4. Bionic pancreas controls blood sugar levels in adults, adolescents with type 1 diabetes
5. Fasting reduces cholesterol levels in prediabetic people over extended period of time
6. Study confirms how the body regulates high levels of CO2 in the blood
7. Children with autism have elevated levels of steroid hormones in the womb
8. Subtle change in DNA, protein levels determines blond or brunette tresses, study finds
9. New research shows humans have more impact on tropical nitrogen levels
10. How have changing sea-levels influenced evolution on the Galapagos Islands?
11. Elevated liver enzyme levels linked to higher gestational diabetes risk
Post Your Comments:
(Date:10/29/2015)... Connecticut , October 29, 2015 ... a biometric authentication company focused on the growing ... smart wallet announces that StackCommerce, a leading marketplace ... be featuring the Wocket® smart wallet on StackSocial ... NXTD ) ("NXT-ID" or the "Company"), a biometric ...
(Date:10/27/2015)... Calif. , Oct. 27, 2015 Synaptics Inc. ... solutions, today announced that Google has adopted the Synaptics ... touch controller solutions to power its newest flagship smartphones, ... by Huawei. --> ... like Google to provide strategic collaboration in the joint ...
(Date:10/23/2015)... Oct. 23, 2015 Research and Markets ( ... "Global Voice Recognition Biometrics Market 2015-2019" report to ... --> The global voice recognition biometrics market to ... --> --> The ... prepared based on an in-depth market analysis with inputs ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... ... metabolism. But unless it is bound to proteins, copper is also toxic to ... researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic study of copper ...
(Date:11/24/2015)... -- Clintrax Global, Inc., a worldwide provider of clinical research services headquartered ... the company has set a new quarterly earnings record in Q3 ... posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , with ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... The Academy ... Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent the ... last few years. Many AMA members have embraced this type of racing and several ...
(Date:11/24/2015)... 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today announced that its ... at 11:00 a.m. Israel time, at the law ... Allon Street, 36 th Floor, Tel Aviv, Israel ... and Izhak Tamir to the Board of Directors; ... directors; , approval of an amendment to certain terms of options ...
Breaking Biology Technology: