Navigation Links
Symptoms of Prader-Willi syndrome associated with interference in circadian, metabolic genes
Date:6/25/2013

ression, rather than coding for proteins. When functioning normally, SNORD116 produces small nucleolar (sno) RNAs and a long non-coding RNA (116HG), as well as a third non-coding RNA implicated in a related disorder, Angelman syndrome. The 116HG long non-coding RNA forms a cloud inside neuronal nuclei that associates with proteins and genes regulating diurnal metabolism in the brain, LaSalle said.

"We thought the cloud would be activating transcription, but in fact it was doing the opposite," she said. "Most of the genes were dampened by the cloud. This long non-coding RNA was acting as a decoy, pulling the active transcription factors away from genes and keeping them from being expressed."

As a result, losing snoRNAs and 116HG causes a chain reaction, eliminating the RNA cloud and allowing circadian and metabolic genes to get turned on during sleep periods, when they should be dampened down. This underlies a complex cycle in which the RNA cloud grew during sleep periods (daytime for nocturnal mice), turning down genes associated with energy use, and receded during waking periods, allowing these genes to be expressed. Mice without the 116HG gene lacked the benefit of this neuronal cloud, causing greater energy expenditure during sleep.

The researchers said that the work provides a clearer picture of why children with Prader-Willi syndrome can't sleep or feel satiated and may change therapeutic approaches. For example, many such children have been treated with growth hormone because of short stature, but this actually may boost other aspects of the disease.

"People had thought the kids weren't sleeping at night because of the sleep apnea caused by obesity," said LaSalle. "What this study shows is that the diurnal metabolism is central to the disorder, and that the obesity may be as a result of that. If you can work with that, you could improve therapies, for example figuring out the best times to administer medications."


'/>"/>

Contact: Phyllis Brown
phyllis.brown@ucdmc.ucdavis.edu
916-734-9023
University of California - Davis Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
2. Bone marrow transplant arrests symptoms in model of Rett syndrome
3. Interventional radiology: Mitigating symptoms, improving quality of life of MS patients
4. Autistic kids born preterm, post-term have more severe symptoms
5. NEIKER and INRA discover that BDA symptoms in grapevine leaves are a sign of esca
6. Ancient foot massage technique may ease cancer symptoms
7. Could poor sleep contribute to symptoms of schizophrenia?
8. Could ending your fatty food habit cause withdrawal symptoms and depression?
9. Promising compound restores memory loss and reverses symptoms of Alzheimers
10. Tamoxifen ameliorates symptoms of Duchenne muscular dystrophy
11. Risk factors identified for prolonged sports concussion symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... , July 27, 2015   Zynx Health ... experience-based clinical improvement solutions, today announced that its ... now available on Android smartphones and tablets. With ... post-care organizations can use ZynxCarebook to securely exchange ... condition, streamline care transitions to other care settings, ...
(Date:7/21/2015)... YORK , July 21, 2015 ... systems, as seen in the recent U.S. Office ... a solution to the infosec conundrum, but developers ... is stored. To address this dilemma, Biometrics-as-a-Service provider ... its Biometric Tokenization SDK for third party integration. ...
(Date:7/9/2015)... , July 07, 2015 ... announced the addition of the "Biometrics for ... Forecasts 2015-2020" report to their offering. ... major contributor to this growth and the forecast ... billion in revenue for companies involved in delivering ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... For the first time in nearly a century drinkers will ... heritage barley from the Victorian period. Old varieties ... the John Innes Centre revived Chevallier from the institute,s Genetic ... records indicate that the variety produced premium quality malt and ...
... analysis, carbon dioxide removal could be used under certain ... but it would not replace the bulk of actual ... allows to separate emissions control from the time and ... important for climate protection," says lead-author Elmar Kriegler. "You ...
... "Many of the great whales which once populated the oceans ... commercial hunting. The committee also worried about how tuna fishing ... And they considered reports about seal hunting and the decline ... October of that year, Congress passed the Marine Mammal Protection ...
Cached Biology News:Cheers to better beer and disease resistance 2CO2 removal can lower costs of climate protection 2CO2 removal can lower costs of climate protection 3Sea mammals find US safe harbor 2Sea mammals find US safe harbor 3Sea mammals find US safe harbor 4
(Date:8/3/2015)... , Aug. 3, 2015   Intrexon Corporation ... first half and second quarter 2015 financial results after ... 2015.  The Company will host a conference call at ... a general business update. The conference call ... 1-412-902-4262 (International), and asking to join the "Intrexon Corporation ...
(Date:7/31/2015)... VEGAS , July 31, 2015 ... seek resources that help them drive positive health ... a vital source of patient care in their ... annual tradeshow and conference, AmerisourceBergen announced a ... its Pharmacy Services Administration Organization and help independent ...
(Date:7/30/2015)... Marshall, MN (PRWEB) , ... July 31, 2015 , ... ... Ralco Enrichment Center at the Lyon County Fair to be held August 5-9 in ... more about where their meals come from and how agriculture impacts their daily lives. ...
(Date:7/30/2015)... ... 30, 2015 , ... The 2015 Market Research Report on the Global ... the global Propanol market with a focus on the Chinese situation. Major companies included ... Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , ...
Breaking Biology Technology:Intrexon to Announce First Half and Second Quarter 2015 Financial Results and Host Conference Call on August 10th 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... Calif., Aug. 19 ReceptorBio,Inc. announced today that ... Inc. (Palo Alto, CA) (Nasdaq: TELK ) ... unique, oral small molecule insulin,receptor activators. These compounds ... drug discovery technology. The,agreement provides for payments related ...
... software,solutions provider for cheminformatics today announced the launch ... JChem. As well as,other improvements, the release sees ... 2 format useful for integrating with Microsoft Office,applications., ... of application programming,interfaces (API,s) and graphic user interfaces ...
... 19 Today Bavarian,Nordic published the company,s interim report ... available on the company,s website. Below is an,extract of ... as events,after the balance sheet date., In the ... DKK 23,million and recorded a loss before tax of ...
Cached Biology Technology:ReceptorBio Announces Diabetes License Agreement With Telik 2ReceptorBio Announces Diabetes License Agreement With Telik 3ChemAxon Launches Marvin and JChem Version 5.1; Name to Structure Generation, OLE 2 and JavaScript Integration 2Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 2Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 3Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 4Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 5Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 6Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 7Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 8Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 9Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008 10
... Antibody Binding: High, 400 ng IgG/cm ... , Binding Interaction: Hydrophobic/Ionic , Performance Certified: ... Flat , Maximum Well Volume: 360 µl ... ,Features, Special optically clear polystyrene ...
... for SFC and SFE applications based upon ... JASCO has recently added the following modules ... ,- The PU-1580-CO2 delivery pump for supercritical ... dioxide as the mobile phase. ,- The ...
... Fixed clamp trays and universal ... Magnetic drive Shaking ... 25 mm amplitude ... to 2000 ml, including Fernbach flasks ...
GLP expression profiling service on the Affymetrix platform. Starting material can be blood, tissue or RNA. 5 day turnaround. Standard and custom post analyses of microarray data available....
Biology Products: