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Switching an antibiotic on and off with light
Date:3/21/2014

of the resulting peptide mimetic can be controlled spatially and temporally with the help of UV and visible light. To demonstrate this, the scientists treated a bacterial film with the inactivated antibiotic and exposed it to light via a mask. As a result, the photoswitchable diarylethene was converted from a closed into an open form. Due to the structural modification induced, the entire substance molecule had a much higher antimicrobial effect. "In the future, such photoactivable antibiotics might be used as smart therapeutic agents against local bacterial infections," Professor Anne S. Ulrich explains. "Usual side effects can also be minimized by switching." Based on this strategy, new peptide-based agents against cancer might be feasible, as the newly developed photoactivable building block can also be applied in other peptide sequences.

The editors of the journal "Angewandte Chemie", in which the researchers of KIT and the University of Kiev present their photo-activable antibiotic and their photoswitch, have rated this publication a "VIP Very Important Paper".


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Contact: Monika Landgraf
presse@kit.edu
49-721-608-47414
Karlsruher Institut fr Technologie (KIT)
Source:Eurekalert  

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