Navigation Links
'Swish-and-spit' test accurate for cancer
Date:12/31/2007

A morning gargle could someday be more than a breath freshener it could spot head and neck cancer, say scientists at the Johns Hopkins Kimmel Cancer Center. Their new study of a mouth rinse that captures genetic signatures common to the disease holds promise for screening those at high risk, including heavy smokers and alcohol drinkers.

Lead investigator Joseph Califano, M.D., says his group at Johns Hopkins asked 211 head and neck cancer patients and 527 individuals without cancers of the mouth, larynx or pharynx to brush the inside of their mouths, then rinse and gargle with a salt solution.

The researchers collected the rinsed saliva and filtered out cells thought to contain one or more of 21 bits of chemically altered genes common only to head and neck cancers. Tumor and blood samples also were collected.

The cellular mishaps occur when small molecules called methyl groups clamp on to the DNA ladder structure of a gene. In the grip of too many methyl groups, these genes can incorrectly switch on or off in a process called hypermethylation. Mass-methylation of particular genes can lead to cancer, the researchers say. Methylation mistakes in other genes could be triggered simply by aging and amount to no more than fine lines and wrinkles.

The challenge is to predict which hypermethylated genes are most specific to cancer, says Califano, an associate professor of otolaryngology head and neck cancer and oncology at Johns Hopkins. And because every cancer process involves a unique genetic fingerprint, combining several gene signatures for the disease rather than using single ones may identify a larger percentage of cancer patients.

Califano and his colleagues report in the January 1 issue of Clinical Cancer Research noted that of 21 hypermethylated genes, seven of them were the best predictors of cancer within cell-laden saliva. Of the seven best, he tested panels of three to five genes on saliva rinses.

One panel correctly iden
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
2. Voice Biometrics Gains Traction as Most Accurate and Convenient Technology to Secure Customer Privacy
3. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
4. Safer, more accurate radiation therapy for expecting mothers
5. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. ESF EURYI award winner aims to stop cancer cells reading their own DNA
8. Protein chatter linked to cancer activation
9. Newly created cancer stem cells could aid breast cancer research
10. Western diet linked to increased risk of colon cancer recurrence
11. Obesity and lack of exercise could enhance the risk of pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... each year, but its deep-blue waters host the ... alien species, including fish, crustaceans, and algae are ... In the open-access journal Frontiers in Marine ... data from a new information system developed by ... of alien species has changed the native biodiversity ...
(Date:9/30/2014)... think of nature as something that we enjoy when we ... Or do we think of ourselves as a part of ... what about a house? , The answers to these ... our actions, our speech and in cultural artifacts. , A ... Washington, the American Indian Center of Chicago and the Menominee ...
(Date:9/30/2014)... captured the popular attention of both children and aquarium ... sold as dehydrated eggs, these tiny brine shrimp readily ... tank of salt water. , Physicists, though, are ... shrimp vertically migrate in large groups in response to ... night and retreating deeper during the day. , Two ...
Breaking Biology News(10 mins):Biodiversity in the Mediterranean is threatened by alien species 2The cultural side of science communication 2Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2
... still images and video, as well as local information ... of Life via new tools that let the public ... collaboration of unprecedented scale. Experts and citizen scientists ... which dedicates a Web page to each known species ...
... , , ... LLC, the image analysis and pattern recognition technology provider, today ... for online signature verification at the tenth International Conference on ... 26 - 29, 2009. Parascript was among 12 participants ...
... An indigenous family living in a mountainous area of ... discover information about genetic mutations associated with acromegaly, a form ... facial features. The information could lead to ... a benign pituitary gland tumor that can be deadly if ...
Cached Biology News:Cool new tools let public contribute to massive interactive online biodiversity encyclopedia 2Cool new tools let public contribute to massive interactive online biodiversity encyclopedia 3Cool new tools let public contribute to massive interactive online biodiversity encyclopedia 4Cool new tools let public contribute to massive interactive online biodiversity encyclopedia 5Cool new tools let public contribute to massive interactive online biodiversity encyclopedia 6Cool new tools let public contribute to massive interactive online biodiversity encyclopedia 7Parascript Technology Wins Online Signature Verification Competition 2Clues to gigantism provided by family in Borneo Mountains 2
(Date:9/30/2014)... WASHINGTON D.C., September 30, 2014 Applying a ... of researchers at Harvard University has demonstrated the ... surface -- work that holds promise for making ... and detailing the sides of next-gen rocket ships ... When light passes through oil in water, it ...
(Date:9/30/2014)... NEW YORK , Sept. 30, 2014 /PRNewswire/ ... Review - 2014 Summary Global Markets ... Review - 2014, provides an overview of the ... focus. This report provides comprehensive information on ... Biotechnology, LLC,s, complete with comparative analysis at various ...
(Date:9/30/2014)... 2014 Nematicide is a type of ... microscopic parasitic roundworms, found in massive quantities virtually ... and animals. Nematicides have tended to be broad-spectrum ... migration through the soil. A single gram of ... With more than 10,000 species classified, they are ...
(Date:9/30/2014)... California (PRWEB) September 30, 2014 ... the level of each type of cholesterol carrier or ... the presence of excessive cholesterol levels in the body, ... precursor condition to heart attack and other cardiovascular disorders. ... worldwide, therefore testing for cholesterol levels on a regular ...
Breaking Biology Technology:Taking thin films to the extreme 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... track for Q4 ... Submission, SEATTLE, ... CTIC) announced today that following a,meeting with the U.S. Food and Drug ... support a submission,for a supplemental Biologics License Application (sBLA). The sBLA will,propose ...
... as pH, heat and light will pave the way ... Being developed by a consortium of UK universities, the ... transfer inside chemical reactors. This technology will provide a ... and agrochemical industries. , Professor Yulong Ding of the ...
... Ill., Sept. 19 Abbott (NYSE:,ABT) will announce its ... the market opens., The announcement will be followed ... 8 a.m. Central time (9 a.m. Eastern), and will ... . An archived edition of the call will be,available ...
Cached Biology Technology:FDA Meeting Provides Green Light for Cell Therapeutics Submission of Supplemental Filing for Zevalin(R) Label Expansion 2FDA Meeting Provides Green Light for Cell Therapeutics Submission of Supplemental Filing for Zevalin(R) Label Expansion 3FDA Meeting Provides Green Light for Cell Therapeutics Submission of Supplemental Filing for Zevalin(R) Label Expansion 4FDA Meeting Provides Green Light for Cell Therapeutics Submission of Supplemental Filing for Zevalin(R) Label Expansion 5
... GRADE ,5-Bromo-4-chloro-3-indoxyl-beta-D-galactopyranoside C 14 H ... 6 ,M.W.= 408.63 ,Assay: Greater ... in DMF) ,Biological Activity: Blue color ... Analysis: Agrees with theoretical values ,Thin ...
...
Antibodies were affinity purified using epitopes specific to RFC1 immobilized on solid support....
prototype Nco I...
Biology Products: