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Sweet chemistry: Carbohydrate adhesion gives stainless steel implants beneficial new functions
Date:4/27/2011

ss steel a difficult material to augment with new functions, particularly with the controlled and close-to-perfect coverage needed for biomedical implants. The Edmonton-based team found that by first coating the surface of the stainless steel with a very thin layer (60 atoms deep) of glass silica using a technique available at the National Institute for Nanotechnology, called Atomic Layer Deposition (ALD), they could overcome the inherent non-reactivity of the stainless steel. The silica provide a well-defined "chemical handle" through which the carbohydrate molecules, prepared in the Alberta Ingenuity Centre for Carbohydrate Science, could be attached. Once the stainless steel had been controlled, the researchers demonstrated that the carbohydrate molecules covered the stainless steel in a highly controlled way, and in the correct orientation to interact with the immune system.

"We are immensely pleased with this progress. We have every expectation that this set of steps creating novel tools for immune system engagement will lead us closer to clinical application aimed at preparing patients for successful organ transplants." stated Dr. Lori West, Professor of Pediatrics, Surgery and Immunology, and Director of Heart Transplant Research at Univ. of Alberta.


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Contact: Dr. Jillian Buriak
jburiak@ualberta.ca
780-641-1740
National Institute for Nanotechnology
Source:Eurekalert

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