Navigation Links
Sweet! Glycoconjugates are more than the sum of their sugars
Date:8/25/2014

There's a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it's many branches are bedecked with sugary ornaments.

It's those ornaments that get all the glory. That's because, according to conventional wisdom, the glycoconjugate's lowly "tree" basically holds the sugars in place as they do the important work of reacting with other molecules.

Now a chemist at Michigan Technological University has discovered that the tree itselfcalled the scaffoldis a good deal more than a simple prop.

"We had always thought that all the biological function resides in the sugar," said Tarun Dam, principal investigator of the Mechanistic Glycobiology Lab at Michigan Tech. "People didn't appreciate that the scaffolds were active."

The discovery opens up new avenues for research, in particular the development of more and better pharmaceuticals. Glycoconjugates are found naturally in the body, but they are also an important class of drugs that includes anything from cancer treatments to vaccines.

To determine if the scaffold had a role to play in biological reactions, Dam and his team built and tested two types of glycoconjugate molecules. They had the same sugars and virtually identical shapes but were comprised of different scaffolds, one made of protein, the other a synthetic. The scientists then tested how the different glycoconjugates reacted with biomolecules called lectins. Lectins play an important role in numerous biological processes and are a target for many glycoconjugate drugs.

If the scaffolds had been inert, the reactions would have been identical. However, the sugars on the protein scaffold reacted with the lectins differently.

"If the scaffolds are different, they can cause my drug to work one way and your drug to work another way, even though they have similar epitopes [sugars]," Dam said. "Tweaking the scaffold can change the drug's function."


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Page: 1

Related biology news :

1. Sweet! Glycocongugates are more than the sum of their sugars
2. 2 servings of salmon a week is healthy for pregnant women and their babies
3. Study finds peoples niceness may reside in their genes
4. Lizard moms may prepare their babies for a stressful world
5. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
6. Vampire jumping spiders identify victims by their antennae
7. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
8. Parasitic plants steal genes from their hosts
9. Cougars are re-populating their historical range, new study confirms
10. Research: Many programs to help diabetics manage their health do work
11. Better looking birds have more help at home with their chicks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sweet! Glycoconjugates are more than the sum of their sugars
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ... is the ultimate driver in long-term mass consumer adoption ...
(Date:12/10/2014)... , December 9, 2014 ... BCARD Platform   ... meeting scheduling solutions for business-to-business (B2B) events, today ... leader in mobile near-field communication (NFC), Bluetooth low ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... such injury as stroke or trauma depends on a particular ... brain chemical acetylcholine, researchers led by James Conner and Mark ... Their finding in rats could help enhance rehabilitation to recover ... or other treatments to enhance the "cholinergic system." , The ...
... of equine herpes virus at Churchill Downs, home of ... preliminary research indicates that vaccines containing weakened live viruses, ... effective in preventing horse herpes than other more widely ... the MLV has been in use for decades, has ...
... may slightly increase risk for schizophrenia* are emerging from a ... National Institute of Mental Health (NIMH). The gene variant produced ... key brain messenger chemical. , The study found that increased ... the neurotransmitter dopamine in the middle of the brain in ...
Cached Biology News:Brain-injury rehabilitation depends on acetylcholine circuitry 2Live vaccines more effective against horse herpes virus 2Live vaccines more effective against horse herpes virus 3Brain Scans Reveal How Gene May Boost Schizophrenia Risk 2Brain Scans Reveal How Gene May Boost Schizophrenia Risk 3
(Date:12/24/2014)... Sigma-Aldrich Corporation (NASDAQ: SIAL ... the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) in ... 2014, thereby completing the U.S. HSR Act antitrust ... the Company by Merck KGaA, Darmstadt, Germany.  ... to closing the transaction, which remains subject to ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 /PRNewswire/ ... study of mazindol in children with attention deficit/hyperactivity disorder ... December 2014 . The paper, titled ... attention deficit/hyperactivity disorder" ( Konofal et al, ... eCollection 2014 ) shows that mazindol might be ...
(Date:12/22/2014)... ROCKVILLE, Md. , Dec. 22, 2014 ... MKT: SYN), a developer of pathogen-specific therapies ... focus on protecting the microbiome, today announced ... a Phase 1a clinical trial of SYN-004, ... the prevention of Clostridium difficile (C. ...
(Date:12/22/2014)... Dec. 22, 2014  Alternative Energy & Environmental ... has signed a letter of intent to acquire ... and patented a nanotechnology-based development platform used to ... enable rapid on-site collection and testing to identify ... issues in an immediate, non-invasive and cost-effective manner. ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5ALNE Announces Intention To Acquire BioTechPharma 2
... SAN DIEGO, April 24 Gen-Probe Incorporated,(Nasdaq: GPRO ... the Morgan,Stanley Global Healthcare Unplugged Conference on May 1, ... scheduled to be,webcast live and may be accessed through ... http://www.gen-probe.com . The webcast will be,available for 30 ...
... TRBN ), today announced that executives will present an,overview of the ... -- April 30: Morgan Stanley Global Healthcare Unplugged Conference ... in Key Biscayne, FL. Dr. Peter Thompson, ... 9:50 a.m. EDT. The presentation will be available via ...
... Wednesday, May 7, 2008 TIME: ... HOST: ... conduct a telephone conference call and,simultaneous webcast on Wednesday, May 7 at 9:30 ... 31, 2008. A,question and answer session will follow., Webcast Instructions, To ...
Cached Biology Technology:Gen-Probe to Webcast Presentation at Morgan Stanley Global Healthcare Unplugged Conference 2Trubion Announces Presentations at April/May Investor Conferences 2Kendle Invites You to Attend its First Quarter 2008 Earnings Conference Call and Webcast 2
... The Paragon CZE 2000 Capillary ... automate clinical serum protein electrophoresis (SPE), ... (IFE/s) for fast and accurate analysis. ... almost no sample preparation and no ...
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
... Plant DNA Kit is designed for fast ... from plant cells and tissues. The bead ... cumbersome DNA isolation procedures such as CTAB, ... procedure, alcohol precipitation is not necessary - ...
... The ApopTag Red In Situ ... situ by the indirect TUNEL method, ... rhodamine fluorochrome. The kit provides indirect ... are analyzed using either fluorescence microscopy ...
Biology Products: