Navigation Links
Sweet! Glycoconjugates are more than the sum of their sugars
Date:8/25/2014

There's a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it's many branches are bedecked with sugary ornaments.

It's those ornaments that get all the glory. That's because, according to conventional wisdom, the glycoconjugate's lowly "tree" basically holds the sugars in place as they do the important work of reacting with other molecules.

Now a chemist at Michigan Technological University has discovered that the tree itselfcalled the scaffoldis a good deal more than a simple prop.

"We had always thought that all the biological function resides in the sugar," said Tarun Dam, principal investigator of the Mechanistic Glycobiology Lab at Michigan Tech. "People didn't appreciate that the scaffolds were active."

The discovery opens up new avenues for research, in particular the development of more and better pharmaceuticals. Glycoconjugates are found naturally in the body, but they are also an important class of drugs that includes anything from cancer treatments to vaccines.

To determine if the scaffold had a role to play in biological reactions, Dam and his team built and tested two types of glycoconjugate molecules. They had the same sugars and virtually identical shapes but were comprised of different scaffolds, one made of protein, the other a synthetic. The scientists then tested how the different glycoconjugates reacted with biomolecules called lectins. Lectins play an important role in numerous biological processes and are a target for many glycoconjugate drugs.

If the scaffolds had been inert, the reactions would have been identical. However, the sugars on the protein scaffold reacted with the lectins differently.

"If the scaffolds are different, they can cause my drug to work one way and your drug to work another way, even though they have similar epitopes [sugars]," Dam said. "Tweaking the scaffold can change the drug's function."


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Page: 1

Related biology news :

1. Sweet! Glycocongugates are more than the sum of their sugars
2. 2 servings of salmon a week is healthy for pregnant women and their babies
3. Study finds peoples niceness may reside in their genes
4. Lizard moms may prepare their babies for a stressful world
5. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
6. Vampire jumping spiders identify victims by their antennae
7. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
8. Parasitic plants steal genes from their hosts
9. Cougars are re-populating their historical range, new study confirms
10. Research: Many programs to help diabetics manage their health do work
11. Better looking birds have more help at home with their chicks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sweet! Glycoconjugates are more than the sum of their sugars
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/22/2017)... 2017   Neurotechnology , a provider of ... announced the release of the SentiVeillance 6.0 ... facial recognition using up to 10 surveillance, security ... The new version uses deep neural-network-based facial detection ... utilizes a Graphing Processing Unit (GPU) for enhanced ...
(Date:3/20/2017)... Pa. , March 20, 2017 PMD ... 2.0 personal spirometer and Wellness Management System (WMS), a ... Founded in 2010, PMD Healthcare is a Medical ... with a mission dedicated to creating innovative solutions that ... life. With that intent focus, PMD developed the first ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 24, 2017 , ... Today, the South ... Recovery’s Advanced Biological Nutrient Recovery (ABNR™) technology at its 4,000,000 gallon per day ... upgrade to sustainably meet current and future nutrient discharge regulations. The ABNR platform, ...
(Date:5/24/2017)... May 24, 2017 (PRWEB) , ... May 24, ... ... Connectivity , Medical systems are increasingly being developed with Wi-Fi connectivity to reduce ... easily moved from room to room. In addition, compact mobile devices including infusion ...
(Date:5/23/2017)... ... May 23, 2017 , ... A recent survey conducted by the Weed ... to control weed in 12 categories of broadleaf crops, fruits and vegetables, while common ... the U.S. and Canada participated in the 2016 survey, the second conducted by WSSA. ...
(Date:5/23/2017)... ... May 22, 2017 , ... NetDimensions has ... the Aragon Research Globe™ for Corporate Learning, 2017. , Aragon Research defines Leaders ... demand, and effectively perform against those strategies. NetDimensions’ ranking as a Leader due ...
Breaking Biology Technology: