Navigation Links
Sweet! Glycoconjugates are more than the sum of their sugars
Date:8/25/2014

There's a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it's many branches are bedecked with sugary ornaments.

It's those ornaments that get all the glory. That's because, according to conventional wisdom, the glycoconjugate's lowly "tree" basically holds the sugars in place as they do the important work of reacting with other molecules.

Now a chemist at Michigan Technological University has discovered that the tree itselfcalled the scaffoldis a good deal more than a simple prop.

"We had always thought that all the biological function resides in the sugar," said Tarun Dam, principal investigator of the Mechanistic Glycobiology Lab at Michigan Tech. "People didn't appreciate that the scaffolds were active."

The discovery opens up new avenues for research, in particular the development of more and better pharmaceuticals. Glycoconjugates are found naturally in the body, but they are also an important class of drugs that includes anything from cancer treatments to vaccines.

To determine if the scaffold had a role to play in biological reactions, Dam and his team built and tested two types of glycoconjugate molecules. They had the same sugars and virtually identical shapes but were comprised of different scaffolds, one made of protein, the other a synthetic. The scientists then tested how the different glycoconjugates reacted with biomolecules called lectins. Lectins play an important role in numerous biological processes and are a target for many glycoconjugate drugs.

If the scaffolds had been inert, the reactions would have been identical. However, the sugars on the protein scaffold reacted with the lectins differently.

"If the scaffolds are different, they can cause my drug to work one way and your drug to work another way, even though they have similar epitopes [sugars]," Dam said. "Tweaking the scaffold can change the drug's function."


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Page: 1

Related biology news :

1. Sweet! Glycocongugates are more than the sum of their sugars
2. 2 servings of salmon a week is healthy for pregnant women and their babies
3. Study finds peoples niceness may reside in their genes
4. Lizard moms may prepare their babies for a stressful world
5. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
6. Vampire jumping spiders identify victims by their antennae
7. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
8. Parasitic plants steal genes from their hosts
9. Cougars are re-populating their historical range, new study confirms
10. Research: Many programs to help diabetics manage their health do work
11. Better looking birds have more help at home with their chicks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sweet! Glycoconjugates are more than the sum of their sugars
(Date:6/23/2015)... , June 22, 2015 ... the addition of the "Body-Worn Temperature Sensors ... Trends and Forecast 2014 - 2020" report ... strategic analysis of the global body-worn temperature sensors ... been segmented on the basis of types, care ...
(Date:6/18/2015)... This report analyzes the worldwide markets for ... Segments, which includes Immunoassay Analyzers and Reagents: Enzyme Immunoassay ... Systems, and Nephelometric Immunoassay Systems. The report provides separate ... , Japan , Europe ... Latin America , and Rest of World. Annual ...
(Date:6/17/2015)... and HILDEN, Germany , June 17, 2015 ... Frankfurt Prime Standard: QIA) today launched new Investigator ® ... laboratories in the United States . The ... analyze multiple key genomic markers (short tandem repeats or STRs) ... Sensor to evaluate the quality of DNA in each sample, ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... for a rare inherited disorder that causes severe burning ... They found that paroxysmal extreme pain disorder (PEPD) is ... peripheral nerve cells—a discovery that they said emphasizes the ... findings of abnormal function in disease also provide insights ...
... Researchers at the University of Illinois at Chicago ... genes determine how well an antipsychotic medication works ... it will cause. , Risperidone, a popular "atypical" ... such as schizophrenia and bipolar disorder. , ...
... sawfly natural enemies in demand, Montana State University ... , This fall, the entomologists are concluding ... that attack wheat stem sawfly larvae that tunnel ... includes entomologists David Weaver, master's graduate Godshen Pallipparambil-Robert ...
Cached Biology News:Origin of inherited pain disorder pinpointed 2Studies look at how genes affect antipsychotic drug response 2Rearing an army to save wheat 2Rearing an army to save wheat 3
(Date:7/1/2015)... Mesa, CA (PRWEB) , ... July 01, 2015 , ... ... traumatic brain injury (TBI) using single photon emission computed tomography (SPECT) according ... The study, which examined over 20,000 brain scans and is believed to be ...
(Date:7/1/2015)...   Decision Resources Group finds that ... are its oral administration, alternative mechanism of action, ... rheumatologists. Otezla was the first oral therapy specifically ... psoriatic arthritis in the United States ... conventional oral treatments including disease-modifying antirheumatic drugs (DMARDs), ...
(Date:7/1/2015)... and BANGALORE, India , July 1, ... company that uses next generation sequencing technology to empower ... A. Storrer as chief executive officer. In his ... be responsible for all strategy, business expansion and worldwide ... has served as Strand,s chairman and CEO since its ...
(Date:7/1/2015)... 1, 2015  Axovant Sciences Ltd. (NYSE:  AXON), ... treatment of dementia, today announced that the company ... at 5:45 p.m. EDT following its presentation of ... Conference 2015 (AAIC). The event ... Dr. Lawrence Friedhoff , Chief Development Officer, ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3
... May 8, 2008, at,8:30 a.m. Eastern/2:30 p.m. Central ... (Nasdaq: CTIC ; MTA) management team will,host ... 2008 first,quarter achievements and financial results., ... 8:30 a.m. Eastern/2:30 p.m. Central European/5:30 a.m. Pacific ...
... Ultrasound Applications for OB/GYN, NEW ORLEANS, ... highlights new products and solutions (booth,#1023) for ... and,Gynecologists Annual Meeting in New Orleans, May ... The latest member of the Siemens ...
... Osteotech, Inc.,(Nasdaq: OSTE ), a leader in ... announced today that its Plexur(R) Technology will be,used ... Jeffrey Hollinger,of Carnegie Mellon University. This program, which ... Center for Biomaterials and Dr. Joachim Kohn of,Rutgers ...
Cached Biology Technology:Siemens Showcases New ACUSON S2000 Ultrasound System, as Well as World's First Pocket Ultrasound System 2Siemens Showcases New ACUSON S2000 Ultrasound System, as Well as World's First Pocket Ultrasound System 3Osteotech's Plexur(R) Technology to Be Used in Craniofacial Reconstruction Program Funded by the Armed Forces Institute of Regenerative Medicine 2Osteotech's Plexur(R) Technology to Be Used in Craniofacial Reconstruction Program Funded by the Armed Forces Institute of Regenerative Medicine 3
Tris-EDTA Buffer Solution, 1X, pH 8.0, sterile...
Chicken polyclonal to YebU ( Abpromise for all tested applications). Antigen: Full length YebU (Escherichia coli)...
Human Cell Line Slides...
Human Cell Line Slides...
Biology Products: