Navigation Links
Sweet! Glycocongugates are more than the sum of their sugars
Date:8/25/2014

There's a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it's many branches are bedecked with sugary ornaments.

It's those ornaments that get all the glory. That's because, according to conventional wisdom, the glycoconjugate's lowly "tree" basically holds the sugars in place as they do the important work of reacting with other molecules.

Now a chemist at Michigan Technological University has discovered that the tree itselfcalled the scaffoldis a good deal more than a simple prop.

"We had always thought that all the biological function resides in the sugar," said Tarun Dam, principal investigator of the Mechanistic Glycobiology Lab at Michigan Tech. "People didn't appreciate that the scaffolds were active."

The discovery opens up new avenues for research, in particular the development of more and better pharmaceuticals. Glycoconjugates are found naturally in the body, but they are also an important class of drugs that includes anything from cancer treatments to vaccines.

To determine if the scaffold had a role to play in biological reactions, Dam and his team built and tested two types of glycoconjugate molecules. They had the same sugars and virtually identical shapes but were comprised of different scaffolds, one made of protein, the other a synthetic. The scientists then tested how the different glycoconjugates reacted with biomolecules called lectins. Lectins play an important role in numerous biological processes and are a target for many glycoconjugate drugs.

If the scaffolds had been inert, the reactions would have been identical. However, the sugars on the protein scaffold reacted with the lectins differently.

"If the scaffolds are different, they can cause my drug to work one way and your drug to work another way, even though they have similar epitopes [sugars]," Dam said. "Tweaking the scaffold can change the drug's function."


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Page: 1

Related biology news :

1. 2 servings of salmon a week is healthy for pregnant women and their babies
2. Study finds peoples niceness may reside in their genes
3. Lizard moms may prepare their babies for a stressful world
4. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
5. Vampire jumping spiders identify victims by their antennae
6. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
7. Parasitic plants steal genes from their hosts
8. Cougars are re-populating their historical range, new study confirms
9. Research: Many programs to help diabetics manage their health do work
10. Better looking birds have more help at home with their chicks
11. The old primates club: Even male monkeys ride their fathers coattails to success
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sweet! Glycocongugates are more than the sum of their sugars
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... L3 ... to announce the company is now a certified iMedNet eClinical and Electronic Data ... enables the company’s clinical research team to build, customize and manage clinical trial ...
(Date:4/24/2017)... Yorba Linda, Ca (PRWEB) , ... April 24, ... ... can protect proteins from thermal denaturation in a cellular milieu; however, the broad ... by a lack of simple platforms with sensitive quantitative readouts. Cell-based thermal stabilization ...
(Date:4/21/2017)... , ... April 21, 2017 , ... ... related applications were the focus of researchers, engineers, product developers, and industry suppliers ... Anaheim. , Sponsored by SPIE, the international society for optics and photonics ...
(Date:4/20/2017)... ... April 20, 2017 , ... Assured ... partnership to offer a full spectrum of digital security goods and services. The ... products and the ground-breaking proactive cybersecurity services and products through Assured Enterprises. The ...
Breaking Biology Technology: