Navigation Links
Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
Date:4/4/2014

A study presented today at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases shows that long-term low levels of vitamin D intake are associated with higher 10-year fracture risk in elderly women.

Vitamin D insufficiency in seniors has been shown to contribute to increased risk of osteoporotic fractures. Previous studies have used single vitamin D measurements to investigate effects on bone. However, in elderly women, relatively little is known about the effects of long-term vitamin D insufficiency on bone health.

The study by Swedish researchers used sequential assessment of serum vitamin D to determine if sustained hypovitaminosis D in elderly women leads to increased 10-year fracture incidence.

Study participants at baseline were 1044 Swedish women, all aged 75, with 715 attending at the 5-year follow up. Serum 25-hydroxyvitamin D (25OHD) levels (nmol/l) were classified as low (<50), intermediate (50󈞷) and high (>75). Women with values in the same 25OHD category at both samplings were considered to have consistently low, intermediate or high levels. Fracture data was followed for 10 years through X-rays at the radiology department.

The results showed that the incidence of hip fractures within 10 years was significantly lower in those women who were vitamin D sufficient (≥50 nmol/l) at baseline and maintained this level at 5 years. The proportion of women sustaining FRAX fractures was 26.2% and 30% in the group which had consistently high or intermediate 25OHD levels compared to 45.6 % in the group with consistently low levels. The incidence of shoulder, radius and vertebral fractures was not associated with 25OHD status in the study. The majority of fractures occurred between 5 and 10 years after baseline (hip 77%; FRAX 64%) however the time to first fracture (hip and FRAX) did not significantly differ between the three categories of 25OHD using either a single or serial measurement.

Professor Kristina Akesson, Clinical and Molecular Osteoporosis Research Unit at Lund University, Chair of the IOF Capture the Fracture Campaign, stated, "This study concludes that in the population sample of elderly women, vitamin D insufficiency sustained over 5-years was associated with increased 10-year risk of osteoporotic fracture."

She added, "This is part of a body of research which increasingly suggests that falls and fracture risk in the elderly could be lower by having higher vitamin D levels. The International Osteoporosis Foundation (IOF) global recommendations for vitamin D advise daily intakes of 800 to 1000 IU/day in seniors for fracture and falls prevention, and if the on-going research shows that vitamin D levels are increased it may be a relatively simple and low-cost public health measure that could have significant positive effects on the incidence of osteoporotic fractures with aging."

Fracture prevention is a key focus of IOF's global campaign 'Capture the Fracture'. The campaign specifically targets secondary fracture prevention by promoting the implementation of coordinator-based fracture liaison services in hospitals and clinics worldwide.


'/>"/>

Contact: C. Jagait
cjagait@iofbonehealth.org
41-229-940-102
International Osteoporosis Foundation
Source:Eurekalert

Related biology news :

1. Unique chromosomes preserved in Swedish fossil
2. UTHealth, Swedish researchers uncover mystery in blot clotting disorder
3. Swedish research useful to Brazilian society, presented by Lund University in São Paulo on 5 Dec. 2012
4. The IPCC Report on Climate Change - Swedish professor Thomas Sterner selected as 1 of the experts
5. Leisure boats threaten the Swedish West Coast archipelago
6. Guelph researchers solve part of hagfish slime mystery
7. Researchers design trees that make it easier to produce paper
8. Researchers manipulate tiny objects with ultrasound
9. UCSB researchers create first regional Ocean Health Index
10. Researchers identify how zinc regulates a key enzyme involved in cell death
11. Researchers reveal a new pathway through the sodium pump
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... Feb. 7, 2017   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce that ... its innovative, highly flexible and award winning eClinical solution, ... iMedNet is a proven Software-as-a-Service (SaaS) clinical ... Capture (EDC), but also delivers an entire suite of ...
(Date:2/3/2017)... Feb. 3, 2017  Texas Biomedical Research Institute announced that ... Larry Schlesinger as the Institute,s new President and CEO. ... May 31, 2017. He is currently the Chair of the ... Center for Microbial Interface Biology at Ohio State University. ... new President and CEO of Texas Biomed," said Dr. ...
(Date:2/2/2017)... TOKYO , Feb. 1, 2017  Central ... innovative and meaningful advances worldwide, The Japan Prize ... Japan Prize, who have pushed the envelope in ... Information and Communication. Three scientists are being recognized ... outstanding achievements that not only contribute to the ...
Breaking Biology News(10 mins):
(Date:2/23/2017)...  In Atlanta, it seems everyone has a chance to ... create an expressive and dynamic community unlike any other. The ... to it. With their newest salon in ... to carry on that tradition with a unique, fresh approach ... salon is the newest of 13 nationwide locations, each of ...
(Date:2/23/2017)... ... 2017 , ... David Nolte, PhD accepted Purdue University’s 2016 ... Research Park of West Lafayette, Indiana. , The top commercialization award is ... success with, commercializing discoveries from Purdue research. “This award is truly an honor. ...
(Date:2/23/2017)... SAN FRANCISCO , Feb. 23, 2017   ... Beyond Type 1, a not-for-profit advocacy and education group ... a grant from Beyond Type 1 to support ViaCyte,s ... and other insulin-requiring diabetes.  For more ... cell-derived cell replacement therapies with a focus on the ...
(Date:2/22/2017)... SAN DIEGO , Feb. 22, 2017  PrimeVax ... , will be presenting at the Annual Biocom Global ... on March 2, at 11:15 AM, at the Torrey ... are thankful to the organizers at Biocom who have ... this international symposium of biotechnology companies, investors, and clinical ...
Breaking Biology Technology: