Navigation Links
Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
Date:4/4/2014

A study presented today at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases shows that long-term low levels of vitamin D intake are associated with higher 10-year fracture risk in elderly women.

Vitamin D insufficiency in seniors has been shown to contribute to increased risk of osteoporotic fractures. Previous studies have used single vitamin D measurements to investigate effects on bone. However, in elderly women, relatively little is known about the effects of long-term vitamin D insufficiency on bone health.

The study by Swedish researchers used sequential assessment of serum vitamin D to determine if sustained hypovitaminosis D in elderly women leads to increased 10-year fracture incidence.

Study participants at baseline were 1044 Swedish women, all aged 75, with 715 attending at the 5-year follow up. Serum 25-hydroxyvitamin D (25OHD) levels (nmol/l) were classified as low (<50), intermediate (50󈞷) and high (>75). Women with values in the same 25OHD category at both samplings were considered to have consistently low, intermediate or high levels. Fracture data was followed for 10 years through X-rays at the radiology department.

The results showed that the incidence of hip fractures within 10 years was significantly lower in those women who were vitamin D sufficient (≥50 nmol/l) at baseline and maintained this level at 5 years. The proportion of women sustaining FRAX fractures was 26.2% and 30% in the group which had consistently high or intermediate 25OHD levels compared to 45.6 % in the group with consistently low levels. The incidence of shoulder, radius and vertebral fractures was not associated with 25OHD status in the study. The majority of fractures occurred between 5 and 10 years after baseline (hip 77%; FRAX 64%) however the time to first fracture (hip and FRAX) did not significantly differ between the three categories of 25OHD using either a single or serial measurement.

Professor Kristina Akesson, Clinical and Molecular Osteoporosis Research Unit at Lund University, Chair of the IOF Capture the Fracture Campaign, stated, "This study concludes that in the population sample of elderly women, vitamin D insufficiency sustained over 5-years was associated with increased 10-year risk of osteoporotic fracture."

She added, "This is part of a body of research which increasingly suggests that falls and fracture risk in the elderly could be lower by having higher vitamin D levels. The International Osteoporosis Foundation (IOF) global recommendations for vitamin D advise daily intakes of 800 to 1000 IU/day in seniors for fracture and falls prevention, and if the on-going research shows that vitamin D levels are increased it may be a relatively simple and low-cost public health measure that could have significant positive effects on the incidence of osteoporotic fractures with aging."

Fracture prevention is a key focus of IOF's global campaign 'Capture the Fracture'. The campaign specifically targets secondary fracture prevention by promoting the implementation of coordinator-based fracture liaison services in hospitals and clinics worldwide.


'/>"/>

Contact: C. Jagait
cjagait@iofbonehealth.org
41-229-940-102
International Osteoporosis Foundation
Source:Eurekalert

Related biology news :

1. Unique chromosomes preserved in Swedish fossil
2. UTHealth, Swedish researchers uncover mystery in blot clotting disorder
3. Swedish research useful to Brazilian society, presented by Lund University in São Paulo on 5 Dec. 2012
4. The IPCC Report on Climate Change - Swedish professor Thomas Sterner selected as 1 of the experts
5. Leisure boats threaten the Swedish West Coast archipelago
6. Guelph researchers solve part of hagfish slime mystery
7. Researchers design trees that make it easier to produce paper
8. Researchers manipulate tiny objects with ultrasound
9. UCSB researchers create first regional Ocean Health Index
10. Researchers identify how zinc regulates a key enzyme involved in cell death
11. Researchers reveal a new pathway through the sodium pump
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... 28, 2017   Acuant , a leading provider ... significant enhancements to new and core technologies building upon ... include mobile and desktop Acuant FRM TM facial ... a real time manual review of identity documents by ... the fastest and most accurate capture software to streamline ...
(Date:2/27/2017)... , Feb. 27, 2017   Strategic Cyber Ventures ... it has led a $3.5 million investment in  Polarity ... Strategic Cyber Ventures is DC based and is led ... Hank Thomas . Ron Gula , also a ... also participated in this series A round of funding. ...
(Date:2/22/2017)... -- With the biometrics market to exceed $10 ... that innovative and agile startups must incorporate into ... changing competitive landscape: multifactor authentication (MFA), point-of-sale (PoS), ... "Companies can no longer afford to cut corners ... Pavlakis , Industry Analyst at ABI Research. "Pairing ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... Franz ... flagship product, AllegroGraph , has been named a ‘Champion’ by Bloor Research in ... the highest ranked product in its class, and, thanks to Gruff, it was rated ...
(Date:3/28/2017)... March 28, 2017 Summary This ... Enzo Biochem and its partnering interests and activities since 2010. ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ... The report will be delivered in PDF format ...
(Date:3/28/2017)... March 28, 2017  Viking Therapeutics, Inc. ("Viking") (NASDAQ: ... of novel therapies for metabolic and endocrine disorders, today ... , Ph.D., will deliver a corporate presentation at H.C. ... Conference, being held April 3, 2017 at the St. ... for this presentation are as follows: ...
(Date:3/28/2017)... ... March 28, 2017 , ... Currently symptomatic therapies for Parkinson’s ... study published in STEM CELLS suggests that human neural stem cell (hNSC) transplantation ... produce more neural cells. , Strategies involving transplantation of these cells into ...
Breaking Biology Technology: