Navigation Links
Swamping bad cells with good in ALS animal models helps sustain breathing
Date:10/19/2008

In a disease like ALS - one that's always fatal and that has a long history of research-resistant biology - finding a proof of principle in animal models is significant.

This week, Johns Hopkins researchers report that transplanting a new line of stem cell-like cells into rat models of the disease clearly shifts key signs of neurodegenerative disease in general and ALS in particular - slowing the animals' neuron loss and extending life.

The new work supports the hypothesis that artificially outnumbering unhealthy cells with healthy ones in targeted parts of the spinal cord preserves limb strength and breathing and can increase survival.

An account of the work appears online this week in Nature Neuroscience.

Two parts of the study hold special interest: One is that the target area for the added cells - parts of the cervical spinal cord that control the diaphragm muscles largely responsible for breathing - reap the most benefit. Forty-seven percent more motor neurons survived there than in untreated model animals. Respiratory failure from diaphragm weakness is the usual cause of death in ALS, also called Lou Gehrig's disease.

"While the added cells, in the long run, didn't save all of the nerves to the diaphragm, they did maintain its nerve's ability to function and stave off death significantly longer," says neuroscientist Nicholas Maragakis, M.D., an associate professor of neurology at Johns Hopkins who led the research team.

"We intentionally targeted the motor neurons in this region," he says, "since we knew that, as in ALS, their death results in respiratory decline."

Also significant is that the transplanted cells, called glial restricted precursors (GRPs), address a well-known flaw in people with ALS and in its animal models. Both humans and models are stunted in their ability to clear away the neurotransmitter glutamate. And excess glutamate - common in ALS - overstimulates the mo
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Forsyth scientists trigger cancer-like response from embryonic stem cells
2. Fat-regenerating stem cells found in mice
3. A link between mitochondria and tumor formation in stem cells
4. Stabilizing force for good communication between neurons and muscle cells found
5. Researchers design artificial cells that could power medical implants
6. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
7. Form of Crohns disease traced to disabled gut cells
8. Scientists identify a molecule that coordinates the movement of cells
9. Models of eel cells suggest electrifying possibilities
10. Breast cancer cells recycle to escape death by hormonal therapy
11. The role of stem cells in renewing the cornea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... make it easier to detect and prevent counterfeit microcircuits ... the agency started performing an in-house microcircuit anti-counterfeit initiative ... of purchased microcircuits while increasing their reliability throughout the ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in this market ... applications. Chemical sensors help in recording of patient data ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... Elsevier, a world-leading provider of scientific, technical and medical ... launch of the new open access journal Photoacoustics ... is to publish original research and review contributions within ... thermoacoustics. Research in this area exploits optically and electromagnetically ...
... the University of Copenhagen, Herlev Hospital and Rigshospitalet have identified ... lipoprotein in the blood. In the long term, the research ... findings have just been published in the Journal of ... (AS) in which the opening of the aortic valve ...
... collaboration will enable university researchers to harness the ... all fields of science and discovery. This ambitious ... of California, Berkeley and the University of Washington, ... campuses and other partners pursuing similar data-intensive science ...
Cached Biology News:Elsevier launches new open access journal: Photoacoustics 2Danish researchers predict risk of valvular heart disease 2Bold new partnership launches to harness potential of data scientists and big data 2Bold new partnership launches to harness potential of data scientists and big data 3Bold new partnership launches to harness potential of data scientists and big data 4
(Date:1/22/2015)... 2015 Selexis SA, a serial innovation ... Banks (RCBs) used for drug discovery to commercial manufacturing, ... include Next-Generation Sequencing (NGS) data packages. The ... manufacturing by ensuring the integrity of the gene, validation ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... has been honored for its commitment to sustainability with inclusion ... Varian is the highest ranked healthcare equipment company among the ... during the World Economic Forum at Davos, Switzerland ...
(Date:12/24/2014)... Md. , Dec. 24, 2014  United Therapeutics Corporation ... Inc. (NYSE: MDT ) has submitted a ... Administration (FDA) for the use of Medtronic,s SynchroMed ® ... developed catheter) for use with United Therapeutics, Remodulin ® ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by ... Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, End ... to 2019” provides a detailed overview of the ... and strategies impacting the preparative and process chromatography ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
... producing tech-savvy workers and managers for Wisconsins knowledge-based ... It will require partnerships between business, education and ... the K-through-gray learning spectrum. , ,The latest example ... by UW-Stout to streamline transfer of credits for ...
... health care software and services company, announced Tuesday the ... The updated product includes integration with FUSION PACS, allowing ... to run from a single, unified end-user desktop application. ... improvements for the radiologist and technologist by eliminating the ...
... to reexamine the federal policy on stem cell research. ... of this debate, because our state is the birthplace of ... Jamie Thomson at the University of Wisconsin-Madison announced that ... isolated stem cells from human embryos and grown them in ...
Cached Biology Technology:Higher ed cooperation will produce more skilled workers for Wisconsin 2Higher ed cooperation will produce more skilled workers for Wisconsin 3Merge eFilm announces release of FUSION RIS version 2.5 2Gov. Doyle comments on unlocking the power of power of stem cell research 2Gov. Doyle comments on unlocking the power of power of stem cell research 3
PTFE/red rubber septum silver aluminum seal ,11 mm seal diam. ...
... enzyme that catalyzes the conversion,of starch ... maltotriose and,dextrins. The level of a-amylase ... are of clinical importance,1-3 while plant ... industry.4, The EnzChek Amylase Assay Kit ...
Rat monoclonal [20d5] to NKG2A + C+ E ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Mouse): CHO transfected cells expressing the B6 allele of NKG2A. Entrez Gen...
... FL is equipped with ... measurement technologies that complement ... advanced features of Fluoroskan ... Fluoroskan Ascent FL provides ...
Biology Products: