Navigation Links
Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine
Date:7/31/2014

ts of which were recently published in the journal Human Vaccines & Immunotherapeutics.

HPV-023

For this study (HPV-023), participants from Brazil were invited to continue follow-up. 437 women from five centers participated in this 36-month long-term follow-up for 113 months (9.4 years). The aim of the study was to evaluate efficacy against HPV-16/18 infection and associated cyto-histopathological abnormalities, persistence of immunogenicity, and safety of the vaccine. During HPV-023, anti-HPV-16/18 antibodies were measured annually by enzyme-linked immunosorbent assay (ELISA) and pseudovirion-based neutralisation assay (PBNA). Cervical samples were tested for HPV DNA every 6 months, and cyto-pathological examinations were performed annually.

Efficacy against HPV-16/18 infections

During HPV-023, no new HPV-16/18-associated infections or cyto-histopathological abnormalities occurred in the vaccine group. In particular, VE against HPV-16/18 incident infection was 100%. VE was 95.6% against incident infection over 9.4 years. Looking at secondary endpoints, the data showed no cases of either 6- or 12-month HPV-16/18 persistent infection in the vaccine group, versus four cases and one case, respectively, in the placebo group during the 26-months follow-up.

Efficacy against cyto-histopathological abnormalities

VE against cyto-histopathological abnormalities was another secondary endpoint of the study. VE was 97.1% against atypical squamous cells of undetermined significance (ASC-US), 95% against low-grade squamous intraepithelial lesion (LISL), and 100% against cervical intraepithelial neoplasia grade 1 (CIN1+) and grade 2 (CIN2+) associated with HPV-16/18.

Immunogenicity

All vaccines remained seropositive to HPV-16/18, with antibody titers remaining several folds above natural infection
'/>"/>

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UGA study finds theres not always safety in numbers when it comes to extinction risk
2. Sensitive test helps improve vaccine safety
3. NIH funds development of tissue chips to help predict drug safety
4. Jeff Crandall Honored With SAE International Arnold W. Siegel International Transportation Safety Award
5. INTEGRIS Health Puts Patient Safety in the Palm of Your Hand
6. Questions about biosafety? Ask a biosafety expert
7. Climate change impacts to US coasts threaten public health, safety and economy
8. Masked mold toxins in food should be included in safety regulations
9. Additional research must be done to ensure safety of pit latrines, new study says
10. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
11. RNA-interference pesticides will need special safety testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 07, 2015 Research ... of the "Biometrics for Banking; Market & ... report to their offering. The adoption ... this growth and the forecast is that by ... for companies involved in delivering biometric systems to ...
(Date:7/9/2015)... Calif. , July 9, 2015 /PRNewswire/ ... leading developer of human interface solutions, today ... the industry,s first fully hardware encapsulated fingerprint ... secure authentication technology is literally off the ... and biometric matching within the fingerprint sensor ...
(Date:7/8/2015)... NEW YORK , July 8, 2015  BD ... announced BD & Guidepoint Mentor, a new ... to Guidepoint,s expert network services. BD ... technologies to improve healthcare delivery and outcomes and, with ... start-up entrepreneur will be able to directly engage with ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... more important to foraging bees than patterns of colored ... Heather Whitney from the University of Cambridge in the ... of pigmentation on flower petals influence bumblebees, behavior suggests ... the nectar. There is little to suggest, however, that ...
... A new study from the University of Colorado Denver ... widely, with some graves lavish and ornate while the vast ... of these burials were so ornate, but what,s striking is ... by almost 10,000 years," said Julien Riel-Salvatore, Ph.D., assistant professor ...
... accumulate higher concentrations of sugars, vitamin C and compounds ... conventional farms, according to research published February 20 in ... Maria Raquel Alcantara Miranda and colleagues from the Federal ... the researchers compared the weights and biochemical properties of ...
Cached Biology News:Bees attracted to contrasting colors when looking for nectar 2Early human burials varied widely but most were simple 2Early human burials varied widely but most were simple 3
(Date:7/30/2015)... ISN improves the efficiency and effectiveness of contractor management systems. ISN,s online contractor management platform, ... 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Dallas, TX , ISN has additional offices in Calgary , ...
(Date:7/30/2015)... Pa. , July 30, 2015  Discovery ... that it has received the second $1.0M tranche ... Innovation Research (SBIR) grant valued at up to ... company,s aerosolized KL4 surfactant as a potential medical ... injury.  Discovery Labs was awarded an initial $1.0 ...
(Date:7/29/2015)... 30, 2015 Sanofi, a ... the second quarter of 2015. CEO Olivier ... its performance in different businesses. Watch ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Topics covered in the ... - Performance drivers - Diabetes ...
(Date:7/29/2015)... SYDNEY , July 29, 2015 US-Australian ... NVGN ) today confirmed it is committed to progressing ... as soon as practicable and to ensure the Company ... Chief Executive Officer, Iain Ross , said the ... including the lead pre-clinical programs, discovery programs and academic ...
Breaking Biology Technology:ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10
... NEW YORK, Sept. 7 Reportlinker.com announces that a ... US Vaccines Market ... to grow 5.5% annually through 2014Demand for vaccines is ... $14 billion in 2014. The market has experienced dramatic ...
... Sept. 7 /PRNewswire-Asia-FirstCall/ -- ... ... var shortURL ... longUrl, so we need to grab the first one. for (var r in data.results) { first_result = ...
... Sept. 7, 2010 Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) ... on Monday, September 13, 2010 at 10:55 a.m. ET / ... and at the Baird Global Healthcare Conference on Tuesday, September 14, 2010 ... in New York. Daniel M. Bradbury, president and chief executive ...
Cached Biology Technology:Reportlinker Adds US Vaccines Market 2Reportlinker Adds US Vaccines Market 3Reportlinker Adds US Vaccines Market 4Reportlinker Adds US Vaccines Market 5Reportlinker Adds US Vaccines Market 6Reportlinker Adds US Vaccines Market 7Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 2Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 3Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 4Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 5Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 6Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 7
... siSolutions siRNA Custom Synthesis ... effective duplex RNA to knockdown ... 21-mers (19 RNA base pairs ... recently-published 27-mers, or other lengths ...
Request Info...
...
Complete cell culture media with cytokines...
Biology Products: