Navigation Links
Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine
Date:7/31/2014

A long-term follow-up study (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity and safety of GlaxoSmithKline's human papilloma virus (HPV) vaccine Cervarix. Women vaccinated with the HPV-16/18 AS04-adjuvanted vaccine were followed for more than nine years, and vaccine efficacy (VE) against incident infection was 100%. This is the longest follow-up report for a licensed HPV vaccine. Visit https://www.landesbioscience.com/journals/vaccines/article/29532/ for the full paper.

HPV and vaccination

Persistent infection with HPV has been clearly established as the necessary cause of the overwhelming majority of cervical cancer cases. At least 40 different HPV types are known to infect the genital mucosa, of which approximately 15 are associated with cervical cancer. Among these types, HPV-16 and HPV-18 are the most common and responsible for approximately 70% of cervical cancers. Both HPV-16 and HPV-18 are included in the two licensed HPV vaccines (GSK's Cervarix and Merck's Gardasil), which are now widely available and used. Evidence of long-term efficacy against vaccine HPV-types is very important, particularly with respect to maintaining public confidence in mass vaccination programs. HPV vaccines initially were recommended for young girls and women 9-25 years of age who have not been exposed to HPV. Since HPV causes not only cervical cancer but also genital warts and anal cancer, HPV vaccines are also recommended for boys in many countries.

Previous clinical studies

An initial double-blind, randomized, multi-center vaccination study (HPV-001; NCT00689741) was started in 2001, followed for up to 27 months, and then followed by a long-term study of the entire cohort for up to 77 months (6,4 years) post initial vaccination (HPV-007; NCT00120848). HPV-007 was followed by an additional extensive study, HPV-023, resul
'/>"/>

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UGA study finds theres not always safety in numbers when it comes to extinction risk
2. Sensitive test helps improve vaccine safety
3. NIH funds development of tissue chips to help predict drug safety
4. Jeff Crandall Honored With SAE International Arnold W. Siegel International Transportation Safety Award
5. INTEGRIS Health Puts Patient Safety in the Palm of Your Hand
6. Questions about biosafety? Ask a biosafety expert
7. Climate change impacts to US coasts threaten public health, safety and economy
8. Masked mold toxins in food should be included in safety regulations
9. Additional research must be done to ensure safety of pit latrines, new study says
10. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
11. RNA-interference pesticides will need special safety testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... --  HOYOS Labs , a leading global authentication infrastructure ... Company will demonstrate multiple biometrics-based technologies under its identity ... on March 23 through 25, 2015, in ... IEEE Biometric Open Protocol Standard; free biometrics-based consumer app, ... system. BOPS was invented by HOYOS Labs and contributed ...
(Date:3/20/2015)... , Mar. 20, 2015 Research and Markets ... addition of the "India Sensors Market Forecast ... The sensor market is projected to ... Consumer electronics, automotive, industrial and healthcare ... in the country. In addition, adoption of MEMS ...
(Date:3/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) ... Global Strategic Business Report" report to their offering. ... in US$ Thousands. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... Latin America . Annual estimates and ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... molecule of life, has an alter ego, research at the ... On rare occasions, its building blocks "rock and roll," ... "We show that the simple DNA double helix exists in ... alternative form is functional," said Hashim M. Al-Hashimi, who is ...
... BEER-SHEVA, ISRAEL, January, 28, 2011 -- Ben-Gurion University ... Company Ltd. (PTT) in Thailand have signed a research ... proprietary green algae strain. The agreement is for ... using BGU,s mutant strain of the green microalgae Parietochloris ...
... often illegally, and moving them outside their native range, according ... Patrick Shirey and Gary Lamberti in the department of biological ... their research last year, nearly 10 percent of the 753 ... Species Act are being sold or, at least, advertised ...
Cached Biology News:DNA caught rock 'n rollin' 2Ben-Gurion U. and PTT Chemical sign R&D agreement to commercialize green algae strain 2Notre Dame biologists call for regulation of rare plant sales 2
(Date:3/30/2015)... March 30, 2015  Spherix Incorporated (Nasdaq: ... the fostering and monetization of intellectual property, today ... No. 3:13-cv-03494-M and  Spherix v. Uniden , Case ... Court for the Northern District of ... Spherix v. Verizon, Case No. 1:14-cv-00721-GBL-TCB, in ...
(Date:3/30/2015)... MADISON, Wis. , March 30, 2015  FUJIFILM ... ("Fujifilm") and Cellular Dynamics International, Inc. (CEO: Robert ... leading developer and manufacturer of fully functioning human cells ... the two companies have entered into a definitive agreement ... offer to be followed by a second step merger. ...
(Date:3/27/2015)... Earlier this year, the Capillus272Pro™ received ... in adult men and women with androgenic alopecia (AGA) ... of IIa-V and Fitzpatrick Classification of Skin phototypes I-IV. ... over-promise and under-deliver, FDA Clearance underscores the safety and ... more than 80 million men and women who suffer ...
(Date:3/27/2015)... YORK , March 27, 2015  Peter Walter ... Biomedical Science for his pioneering work on how proteins ... components of a regulatory mechanism that cells use to ... Dr. Walter is a professor of biochemistry at the ... groundwork for treating a range of human diseases related ...
Breaking Biology Technology:Spherix Provides Update on Litigation vs. VTech, Uniden and Verizon 2Spherix Provides Update on Litigation vs. VTech, Uniden and Verizon 3Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 2Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 3Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 4Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 5Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 6Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 7Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 8Dr. Robert Leonard Applauds FDA Clearance of Capillus272Pro™ Hair Loss Laser Cap 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3
... GenTel BioSurfaces, Inc., of Madison has been ... for biomolecules and labeling agents, GenTel announced on Tuesday. ... System labeling reagents of Kreatech Biotechnology BV ... kit formats. The kits are validated for use on ...
... this fall that will help University of Wisconsin System officials ... that was put on hold after approximately $25 million was ... project was determined to be fraught with problems, including a ... Benefits Systems project (ABPS) for the UW System was put ...
... manufacturer of diode lasers for industrial, defense, and ... expansion funding, the company reported on Wednesday. , ... Equity Group, LLC and included all of ... Venture Partners, Advanced Technology Ventures, EDF Ventures, CenterPoint ...
Cached Biology Technology:UW working to salvage multi-million HR software project 2UW working to salvage multi-million HR software project 3UW working to salvage multi-million HR software project 4UW working to salvage multi-million HR software project 5Alfalight receives $7 million in expansion funding 2