Navigation Links
Suspended animation protects against lethal hypothermia, study shows
Date:6/10/2010

SEATTLE How is it that some people who apparently freeze to death, with no heart rate or respiration for extended periods, can be brought back to life with no long-term negative health consequences? New findings from the laboratory of cell biologist Mark B. Roth, Ph.D., of Fred Hutchinson Cancer Research Center, may help explain the mechanics behind this widely documented phenomenon.

Reporting online ahead of the July 1 print issue of Molecular Biology of the Cell, Roth, a member of the Hutchinson Center's Basic Sciences Division, and colleagues show that two widely divergent model organisms yeast and nematodes, or garden worms can survive hypothermia, or potentially lethal cold, if they are first put into a state of suspended animation by means of anoxia, or extreme oxygen deprivation.

Roth and colleagues found that under normal conditions, yeast and nematode embryos cannot survive extreme cold. After 24 hours of exposure to temperatures just above freezing, 99 percent of the creatures expire. In contrast, if the organisms are first deprived of oxygen and thus enter a state of anoxia-induced suspended animation, 66 percent of the yeast and 97 percent of the nematode embryos will survive the cold. Once normal growth conditions are resumed upon rewarming and reintroduction of oxygen the organisms will reanimate and go on to live a normal lifespan.

A better understanding of the potentially beneficial, symbiotic relationship between low oxygen and low temperatures may one day lead to the development of improved techniques for extending the shelf life of human organs for transplantation, Roth said.

"We have found that extension of survival limits in the cold is possible if oxygen consumption is first diminished," he said. "Our experiments in yeast and nematodes suggest that organs may last longer outside the body if their oxygen consumption is first reduced before they are made cold."

Roth's laboratory studies the potenti
'/>"/>

Contact: Kristen Lidke Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Conservation International gets support from Dreamworks Animation to protect giant pandas
2. Same gene protects from 1 disease, opens door to another
3. Intravenous gene therapy protects normal tissue of mice during whole-body radiation
4. Rosemary chicken protects your brain from free radicals
5. Protein protects brain against compound in lead poisoning, liver disease
6. Protein protects lung cancer cells from efforts to fix or kill them
7. Blueberry and green tea containing supplement protects against stroke damage
8. Protein protects embryonic stem cells versatility and self-renewal
9. Evidence now suggests eating soy foods in puberty protects against breast cancer
10. Bird flu vaccine protects people and pets
11. Flu shot protects kids -- even during years with a bad vaccine match
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... of America (ESA) is pleased to announce the selection ... the Society. Honorary Membership acknowledges those who have served ... in the affairs of the Society that has reached ... by the ESA Governing Board and then voted on ... at the Awards Ceremony at Entomology 2014, ESA,s Annual ...
(Date:8/28/2014)... . The zebrafish, ... striking pattern of blue stripes alternating with golden stripes. Three ... yellow cells emerge during growth in the skin of the ... compose the characteristic colour pattern. ,While it was ... form proper stripes, the embryonic origin of the pigment cells ...
(Date:8/28/2014)... ROCHESTER, Minn. A Mayo Clinic researcher and his ... speed up and enhance the process of re-engineering cells ... that uses network biology methods to aid stem cell ... cell engineering are described in two back-to-back papers in ... has a broad range of uses for all types ...
Breaking Biology News(10 mins):Fred Baxendale selected as Honorary Member of the Entomological Society of America 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3New tool aids stem cell engineering for medical research 2
... to publish its official English-language journal, Human Cell ... at Springer in early 2011. The journal was previously ... a forum for international research on all aspects of human ... studies using ES/iPS cells or tissue stem cells derived from ...
... ANN ARBOR, Mich.---Mercury contamination, a worldwide environmental ... in California,s San Francisco Bay. Mercury mining ... 1900s, combined with present day oil refineries, chemical ... enough mercury to threaten wildlife and prompt a ...
... MOUNTAIN VIEW, CA January 25, 2011 23andMe,s ... both phenotypic and genetic data from 500 individuals diagnosed ... way towards its goal of building a sarcoma research ... completed its Independent Sarcoma Scientific Advisory Committee with the ...
Cached Biology News:Human Cell joins Springer's publishing program 2Mercury in Bay Area fish a legacy of California mining 2Mercury in Bay Area fish a legacy of California mining 323andMe sarcoma research community reaches 500 and announces Sarcoma Scientific Advisory Committee 2
(Date:8/29/2014)... A major challenge before new biotechnology start-up ... of Boston-Cambridge, is gaining visibility that can lead to ... Director of Boston’s Adult Stem Cell Technology Center, LLC ... of his company an important priority since he started ... a social media marketing campaign launched earlier ...
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... 28, 2014 Best Sanitizers, Inc., the ... alcohol-based hand sanitizer, asks food processors and food handling ... hand sanitizer they’re currently using to Best Sanitizers’ ... is critical to fighting cross-contamination and the spread of ... believes there are key criteria that make a hand ...
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... (Nasdaq: NEOG ) has developed the quickest ... in food and environmental samples. Neogen,s revolutionary ... test available for the system, and will provide results ... available molecular amplification tests require up to 3 hours ...
... RICHMOND, Calif., April 25, 2012  Sangamo BioSciences, Inc. (Nasdaq: ... its first quarter 2012 financial results on Wednesday, May 2, ... followed by a conference call at 5:00 p.m. ET, which ... During the conference call, the company will review the financial ...
...  The Chair of RIFM,s Board of Directors, Dr. Sean ... new president of the Research Institute for Fragrance Materials, ... (Logo: http://photos.prnewswire.com/prnh/20101215/DC17717LOGO ) ... in Piscataway, N. J. where he served as V.P., ...
Cached Biology Technology:Neogen launches the fastest molecular pathogen test 2Sangamo BioSciences Announces First Quarter 2012 Conference Call and Webcast 2RIFM Board Names New President 2
... units/µL ,• High specific activity and processivity ... 'A' overhang ,• Processes ... high activity in primer extension and other ... of the enzyme, each lot has been ...
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/L; 1 tube of 1, 000 units enzyme/tube w/Buffer II and MgCl2...
... 5 units/µL ,• High specific activity and ... an 'A' overhang ,• Processes ... high activity in primer extension and other ... of the enzyme, each lot has been ...
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/uL; 25 tubes of 1, 000 units enzyme/tube w/ Buffer I...
Biology Products: