Navigation Links
Surprising infection inducing mechanism found in bacteria
Date:5/18/2010

A research appearing in Nature, with the participation of doctors Susana Campoy and Jordi Barb from the Department of Genetics and Microbiology at UAB, demonstrates that bacteria have a surprising mechanism to transfer virulent genes causing infections. The research describes an unprecedented evolutionary adaptation and could contribute to finding new ways of treating and preventing bacterial infections.

Pathogenic genes are responsible for making bacteria capable of causing diseases. These genes cause bacteria to produce specific types of toxins and determine whether or not a disease will later develop in an individual. These virulent genes can be passed from one bacteria to another if the genome segments containing them, known as pathogenicity islands, are transferred from one to another.

A team of researchers from Universitat Autnoma de Barcelona, together with members of the CSIC Institute for Agrobiotechnology, Public University of Navarre, Virginia Commonwealth University, and New York University Medical Center, coordinated by the Valencian Institute for Agronomic Research (IVIA) and CEU-Cardenal Herrera University, have studied the mechanisms producing virulence in staphylococcus bacteria and causing the Toxic Shock Syndrome, a rare but potentially fatal illness in 50% of the cases.

Researchers observed how pathogenicity islands underwent an unprecedented evolutionary adaptation to be able to transfer pathogens to other innocuous bacteria and thus transform them into virulent bacteria.

Under normal conditions, pathogenicity islands produce the protein Stl, which binds to the DNA segment containing virulent genes and represses the transfer of the island. However, sometimes bacteria become infected with a virus which packages and transfers these virulent genes to other bacteria.

Scientists have discovered that these islands can detect the presences of a virus, eliminate the repression produced by Stl, and thus commence a replication and packaging cycle. The island is then capable of transference and of making other harmless bacteria turn virulent.

The new mechanism discovered by scientists is of great importance for the development of new treatments for diseases caused by bacterial toxins. The pathogenicity island studied is a prototype of a new family of virulent DNA recently discovered which also can be transferred to other species of bacteria such as Listeria monocytogenes, responsible for a large number of intoxications.

Less than a year ago, the research group led by Dr Jordi Barb from the Department of Genetics and Microbiology at UAB published an article in Science on the antibiotic resistance mechanism in bacteria ["The SOS Response Controls Integron Recombination". Science. Vol. 324 (2009)]. "With the two articles in Nature and Science we have basic knowledge of the mechanisms used by bacteria to cause infections. This "doublet" in science not only demonstrates the quality of research being carried out at universities in our country, but also the possibility of creating applications for the treatment and prevention of bacterial infections", says Dr Jordi Barb.


'/>"/>

Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

Related biology news :

1. European Union forests expanding, absorbing carbon at surprisingly high rate: study
2. The surprising story of Charles Darwin and his homeopathic doctor
3. UVA reports surprising findings related to myotonic muscular dystrophy
4. Electrospray droplet research yields surprising, practical results
5. Language of a fly proves surprising
6. Surprising discovery from first large-scale analysis of biodiversity and biogeography of viruses
7. The surprising power of the pill
8. Major collaboration uncovers surprising new genetic clues to diabetes
9. Climate changing gas from some surprising microbial liaisons
10. Surprisingly rapid changes in the Earths core discovered
11. Study reveals surprising details of the evolution of protein translation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/7/2016)... NEW YORK , Jan. 7, 2016 ... as regional markets for biometric technologies and devices, identifying ... application market for various types of biometric devices. Includes ... report to: Identify newer markets and explore the ... of biometric devices. Examine each type of biometric technology, ...
(Date:1/7/2016)... MIAMI , Jan. 7, 2016  A United ... became the first court in the country to interpret ... landmark lawsuit to go forward against the photo website ... LLP. BRIAN NORBERG vs. SHUTTERFLY, INC.; ... the plaintiff alleges that Shutterfly violates the Illinois Biometric ...
(Date:1/6/2016)... , Jan. 6, 2016 Based on ... Frost & Sullivan recognizes MorphoTrak, LLC, a U.S. ... American Frost & Sullivan Company of the Year ... scanning technology, Morpho Wave™ , has consolidated the ... fingerprint biometrics market. Morpho Wave is a ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... ... February 04, 2016 , ... Shimadzu ... quad LC-MS, host live demos and poster sessions, and present on the analysis ... conference takes place March 6 to 10 at the Georgia World Congress Center ...
(Date:2/4/2016)... , Feb. 4, 2016 Beike Biotechnology, the ... medical institutions attended a ceremony in late 2015 to ... cell therapy in 2016. --> ... Translation Platform for Personalized Cell Therapy" was hosted by ... Production Center, both subsidiaries of Beike Biotechnology Co., Ltd. ...
(Date:2/4/2016)... British Columbia and MENLO PARK, Calif. ... (OTCQX: DMPI) ("DelMar" and the "Company"), a biopharmaceutical company ... today announced that it will present at the 18 ... Monday, February 8, 2016 at 10:00 a.m. EST in ... Bacha , DelMar,s president and CEO, will provide an update ...
(Date:2/4/2016)... Feb. 4, 2016 ContraVir Pharmaceuticals, Inc. (NASDAQ: ... development and commercialization of targeted antiviral therapies, announced today ... Conference 2016, to be held February 8-9, 2016, at ... 2016 Disruptive Growth & Healthcare Conference, taking place in ... 2016. James Sapirstein , Chief Executive Officer ...
Breaking Biology Technology: