Navigation Links
Surprise role of nuclear structure protein in development
Date:11/24/2011

Baltimore, MD Scientists have long held theories about the importance of proteins called B-type lamins in the process of embryonic stem cells replicating and differentiating into different varieties of cells. New research from a team led by Carnegie's Yixian Zheng indicates that, counter to expectations, these B-type lamins are not necessary for stem cells to renew and develop, but are necessary for proper organ development. Their work is published November 24 by Science Express.

Nuclear lamina is the material that lines the inside of a cell's nucleus. Its major structural component is a family of proteins called lamins, of which B-type lamins are prominent members and thought to be absolutely essential for a cell's survival. Mutations in lamins have been linked to a number of human diseases. Lamins are thought to suppress the expression of certain genes by binding directly to the DNA within the cell's nucleus.

The role of B-type lamins in the differentiation of embryonic stem cells into various types of cells, depending on where in a body they are located, was thought to be crucial. The lamins were thought to use their DNA-binding suppression abilities to tell a cell which type of development pathway to follow.

But the team--including Carnegie's Youngjo Kim, Katie McDole, and Chen-Ming Fan--took a hard look at the functions of B-type lamins in embryonic stem cells and in live mice.

They found that, counter to expectations, lamin-Bs were not essential for embryonic stem cells to survive, nor did their DNA binding directly regulate the genes to which they were attached. However, mice deficient in B-type lamins were born with improperly developed organsincluding defects in the lungs, diaphragms and brainsand were unable to breathe.

"Our works seems to indicate that while B-type lamins are not part of the early developmental tissue-building process, while they are important in facilitating the integration of
'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
410-246-3032
Carnegie Institution
Source:Eurekalert

Page: 1 2

Related biology news :

1. Finger (mal)formation reveals surprise function of desert DNA
2. New cellular surprise may help scientists better understand human mitochondrial diseases
3. Montana State University team surprised by results of lung, mold study
4. Pearl-flowered legume a surprise new find in the Cape Snowy Mountains, South Africa
5. Surprises from the ocean: Marine plankton and ocean pH
6. Surprise! Biodiversity and resource use may co-exist in tropical forests
7. Genome of barley disease reveals surprises
8. Low elevations hold climate surprises
9. Surprise: Scientists discover that inflammation helps to heal wounds
10. Popping cells surprise living circuits creators
11. Natural selection for moderate testosterone surprises scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... BostonThe American Society for Bone and Mineral Research awarded ... of Medicine (BUSM), with the 2014 Louis V. Avioli ... at BUSM, is internationally known for revolutionizing the understanding ... , The award honors a member of the ... fundamental contributions to bone and mineral basic research. It ...
(Date:7/11/2014)... of Standards and Technology (NIST) need a special ... often prove that necessity is truly the mother ... M. Lorna De Leoz and Stephen Stein, NIST ... Glycomics is the study of the abundant, often-branched ... proteins and lipids and influence cellular processes, including ...
(Date:7/11/2014)... of researchers, including scientists from the Max Planck Institute ... a major step in understanding photosynthesis, the process by ... oxygen in its atmosphere and which is therefore crucial ... , The researchers report the first direct visualization of ... step in which a specific protein complex, photosystem II, ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2A first direct glimpse of photosynthesis in action 2
... Chinese . College Park, MD (August 3, 2010) ... in molecular biology today. The devices, which can be used ... sequences, are employed in everything from forensic analysis to disease ... colleagues at Simon Fraser University in Burnaby, Canada have combined ...
... YORK, N.Y., August 3, 2010) Autism Speaks, ... importance of research on environmental risk factors for ... on Environment & Public Works, Subcommittee on Children,s ... health factors associated with autism spectrum disorders (ASD) ...
... of dollars to cap it, and it could take billions ... Gulf of Mexico is acknowledged the environmental catastrophe of the ... help "bioremediate" the remaining problems. Prof. Eugene Rosenberg ... Molecular Microbiology and Biotechnology are using naturally occurring oil-munching bacteria, ...
Cached Biology News:Autism Speaks on US Senate hearing on potential environmental health factors in autism 2Autism Speaks on US Senate hearing on potential environmental health factors in autism 3A nemesis for oil spills 2
(Date:7/10/2014)... 10, 2014  Franciscan St. Anthony Health-Crown ... for respiratory monitoring outside the operating room, ... in embracing state-of-the-art patient safety technology. ... breathing and can alert medical caregivers when ... amount of carbon dioxide the patient is ...
(Date:7/10/2014)... OAKS, Calif., July 10, 2014   Ceres, Inc ... and seed company, announced today financial results for the ... update on its business. Ceres reported that ... in product performance this growing season in Brazil, which ... affected the company,s sorghum evaluation areas for part of ...
(Date:7/10/2014)... extremely challenging because there are many genetic variants that ... Now investigators reporting in the July 3rd issue of ... describe a strategy that may help reveal how such ... environmental exposures to affect the development of the nervous ... predispose individuals to schizophrenia. , The work takes ...
(Date:7/10/2014)... the University of Illinois at Urbana-Champaign provides new ... of spin and heat at the nanoscale, and ... for data storage and information processing. , ... momentum. In a typical charge current, electrons, spin-angular-momentum ... explained David Cahill, a professor of materials science ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2University of Illinois study advances limits for ultrafast nano-devices 2
... would let you see a virus in a drop of blood ... says Durdu Guney, make ultra-high-resolution microscopes as commonplace as cameras in ... also known as a perfect lens, though people are trying. Optical ... limit, so even the best won,t usually let us see objects ...
... of electronics at the nanoscale may be even ... conductance in ferroelectric nanodomains by researchers at Oak ... their polarization with the application of an electric ... as ultrasound machines and sensors. Now, discoveries about ...
... 2012 Advanstar|CBI recently announced the full agenda for ... Forum takes place March 6-7, 2012 in Baltimore, MD. ... Eli Lilly, Genentech, AstraZeneca, Shire Human Genetic Therapies and ... Needy Meds recently interviewed PAP,s Senior Program Manager, Sharon ...
Cached Biology Technology:Almost perfect: A breakthrough in superlens development 2ORNL experiments prove nanoscale metallic conductivity in ferroelectrics 2
... using advanced automated high throughput microplate processing equipment that dispenses ... accommodate virtually any lot size of the following formats (with ... 8 and 12 well strips, ... 384 well microplate, 1536 ...
... are based on well-established periodate chemistry, ... and reproducible. This kit contains all ... or antibody, including ready-to-use buffers and ... HRP is supplied ready-to-use and requires ...
... Acridinium NHS ester can be ... nucleic acids. The covalently bound ... chemiluminescence in the presence of ... proteins can be used as ...
... hold up to 6 strain chambers with precise ... use design ensures that cells grow over long ... compression. This unit allows you to control the ... 64 unique strain settings. The instrument fits in ...
Biology Products: