Navigation Links
Surprise: Scientists discover that inflammation helps to heal wounds
Date:10/4/2010

A new research study published in The FASEB Journal (http://www.fasebj.org) may change how sports injuries involving muscle tissue are treated, as well as how much patient monitoring is necessary when potent anti-inflammatory drugs are prescribed for a long time. That's because the study shows for the first time that inflammation actually helps to heal damaged muscle tissue, turning conventional wisdom on its head that inflammation must be largely controlled to encourage healing. These findings could lead to new therapies for acute muscle injuries caused by trauma, chemicals, infections, freeze damage, and exposure to medications which cause muscle damage as a side effect. In addition, these findings suggest that existing and future therapies used to combat inflammation should be closely examined to ensure that the benefits of inflammation are not eliminated.

"We hope that our findings stimulate further research to dissect different roles played by tissue inflammation in clinical settings, so we can utilize the positive effects and control the negative effects of tissue inflammation," said Lan Zhou, M.D., Ph.D., a researcher involved in the work from the Neuroinflammation Research Center/Department of Neurosciences/Lerner Research Institute at the Cleveland Clinic in Ohio.

Zhou and colleagues found that the presence of inflammatory cells (macrophages) in acute muscle injury produce a high level of a growth factor called insulin-like growth factor-1 (IGF-1) which significantly increases the rate of muscle regeneration. The research report shows that muscle inflammatory cells produce the highest levels of IGF-1, which improves muscle injury repair. To reach this conclusion, the researchers studied two groups of mice. The first group of mice was genetically altered so they could not mount inflammatory responses to acute injury. The second group of mice was normal. Each group experienced muscle injury
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. NOAA-sponsored scientists first to map offshore San Andreas Fault and associated ecosystems
2. Scripps Research scientists win $65 million in new grants to reveal form and function of proteins
3. Chromosomal break gives scientists a break in finding new puberty gene
4. Scientists discover a new way our bodies control blood pressure: the P450-EET system
5. Scientists reveal important clues to how bacteria and viruses are identified as enemies
6. Going green: New program provides vital support for plant scientists
7. Notre Dame and Wyoming scientists genetically engineer silkworms to produce artificial spider silk
8. Hepatitis C virus faces new weapon from Florida State scientists
9. Light workout: Stanford scientists use optogenetics to effectively stimulate muscle movement in mice
10. Scientists release first cultivated ohelo berry for Hawaii
11. Fruit flies help Yale scientists sniff out new insect repellents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Caesarean section have a different intestinal flora than children delivered ... is the case and what it means for the immune ... therefore decided to scrutinise the impact of birth on the ... mouse pups. , The study shows that ... of cells that strengthen the immune system, says Camilla Hartmann ...
(Date:7/9/2014)... switch out one gene for another in a line ... fiction to reality within this decade. As with any ... of fixing disease-causing genes in humans, for example--as well ... put one of those concerns to rest: using gene-editing ... of mutations in the cells. The new results were ...
(Date:7/9/2014)... deer hunts in Indiana state parks have helped restore ... caused by overabundant populations of white-tailed deer, a Purdue ... Jenkins, associate professor of forest ecology, found that a ... hunts in state parks has successfully spurred the regrowth ... by browsing deer. , Jenkins said that while ...
Breaking Biology News(10 mins):Mouse study: Natural birth may strengthen the immune system 2No extra mutations in modified stem cells, study finds 2No extra mutations in modified stem cells, study finds 3Hunting gives deer-damaged forests in state parks a shot at recovery 2
... 12 surgeons and 21 surgical residents, video game skill ... a simulated surgery skills course, according to a report ... of the JAMA/Archives journals. , James C. Rosser Jr., ... colleagues asked 33 surgeons (21 residents and 12 attending ...
... speculated that lead poisoning may have played a role in ... have been caused by the concentration of grape juice in ... damage to the environment, the annual production of lead continues ... glass, and electronic components. However, there has thus far been ...
... made to retain naturally occurring compounds called flavanols may ... and chart the course for future research that could ... dementia, according to a panel of scientists who presented ... Association for the Advancement of Science (AAAS). , Several ...
Cached Biology News:Lead with a poisonous electron shield 2Flavanols in cocoa may offer benefits to the brain 2Flavanols in cocoa may offer benefits to the brain 3
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... 2010 Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ... LLY ) today announced final results from a retrospective ... risk of acute pancreatitis among initiators of BYETTA® (exenatide) ... antidiabetic therapies. These findings were presented at the 70th ...
... N.C. , June 25 Ruedi Waeger , Ph.D., former ... Board of Directors, was honored with the Robert W. Reilly Leadership award ... . , , , ... the Plasma Protein Therapeutics Association (PPTA) and recognizes individuals who exemplify the leadership ...
... , CRANBURY, N.J. , June 25 Palatin ... has entered into definitive agreements with certain accredited investors to sell ... of $0.20 per unit for gross proceeds of ... expenses.  Each unit will consist of one share of common stock ...
Cached Biology Technology:Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 2Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 3Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 4Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 5Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 6Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 7Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 8Ruedi Waeger Receives the 2010 Robert W. Reilly Leadership Award from Plasma Protein Therapeutics Association 2Palatin Technologies, Inc. to Raise $2.0 Million Dollars in Registered Direct Offering 2Palatin Technologies, Inc. to Raise $2.0 Million Dollars in Registered Direct Offering 3
GlutaMAX-I Supplement...
Chemically Defined Lipid Concentrate...
... Cell Dissociation Buffers are membrane-filtered isotonic ... chelating agents and cell-conditioning agents in ... salt solution or Ca2+- and ... of mammalian cells from support substrates ...
... g Blocking Reagent , 2 x 50 ml 10X ... , 0.2 ml BL21 glycerol stock , 0.2 ... stock , 1010 pfu T7Select Positive Control Lysate , ... l S-protein HRP Conjugate , 2 ml T7Select S-protein ...
Biology Products: