Navigation Links
Surface tension drives segregation within cell mixtures
Date:10/6/2008

What does a mixture of two different kinds of cells have in common with a mixture of oil and water? The same basic force causes both mixtures to separate into two distinct regions.

That is the conclusion of a new three-dimensional computer model of the cell sorting process produced by Shane Hutson, assistant professor of physics at Vanderbilt University, and his colleagues at the University of Waterloo in Canada that is described in the Oct. 3 issue of the journal Physical Review Letters.

The force in question is surface tension a property of liquids that arises from intermolecular forces specifically an effect called the Plateau-Rayleigh Instability that explains the tendency of water to form droplets.

Mechanical interactions between cells play an important role in a number of biological processes, including the development of embryos and the spread of cancer. Understanding these interactions is particularly important in current efforts to create artificial tissues.

"In order to design and control the building of artificial tissues of any sort, we have to understand how cell/cell interactions drive shape and structure formation at a very deep level," Hutson says.

Currently, these interactions are often modeled using analogs from fluid mechanics including viscosity and surface tension. "What we have shown is a fascinating new role for surface tension in the process of cell sorting the ability of random mixtures of two cell types to spontaneously sort themselves into two distinct domains," Hutson says.

Previous 2-D and 3-D models of cell sorting had indicated that surface tension alone was not powerful enough to drive this "unmixing" process by itself, leading researchers to propose that the cells themselves must also change shape randomly to keep the process from grinding to a halt before it is completed.

The new computer model looked at the structure of the 3-D mixtures in greater detail. It showed that in mixtures where the minority cell type makes up at least 25 percent of the mix, more than 95 percent of the minority cells are in direct contact with other minority cells instead of being totally surrounded by majority cells and found that this contact enhances the surface tension effect, allowing it to drive the sorting process without assistance from cell fluctuations.


'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Related biology news :

1. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
2. New method reveals substances on surfaces of any kind
3. Biocapture surfaces produced for study of brain chemistry
4. Study of sugars on cell surface identifies key factor in flu infection
5. Its all about geometry: Protein contact surfaces hold key to cures
6. New horizons in modelling surface processes
7. Geology and biology meet in the history of US southwestern desert surface waters
8. Killer pulses help characterize special surfaces
9. Coating copies microscopic biological surfaces
10. Understanding hypertension in African Americans proves elusive
11. Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Surface tension drives segregation within cell mixtures
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
Breaking Biology Technology: