Navigation Links
Surface tension drives segregation within cell mixtures
Date:10/6/2008

What does a mixture of two different kinds of cells have in common with a mixture of oil and water? The same basic force causes both mixtures to separate into two distinct regions.

That is the conclusion of a new three-dimensional computer model of the cell sorting process produced by Shane Hutson, assistant professor of physics at Vanderbilt University, and his colleagues at the University of Waterloo in Canada that is described in the Oct. 3 issue of the journal Physical Review Letters.

The force in question is surface tension a property of liquids that arises from intermolecular forces specifically an effect called the Plateau-Rayleigh Instability that explains the tendency of water to form droplets.

Mechanical interactions between cells play an important role in a number of biological processes, including the development of embryos and the spread of cancer. Understanding these interactions is particularly important in current efforts to create artificial tissues.

"In order to design and control the building of artificial tissues of any sort, we have to understand how cell/cell interactions drive shape and structure formation at a very deep level," Hutson says.

Currently, these interactions are often modeled using analogs from fluid mechanics including viscosity and surface tension. "What we have shown is a fascinating new role for surface tension in the process of cell sorting the ability of random mixtures of two cell types to spontaneously sort themselves into two distinct domains," Hutson says.

Previous 2-D and 3-D models of cell sorting had indicated that surface tension alone was not powerful enough to drive this "unmixing" process by itself, leading researchers to propose that the cells themselves must also change shape randomly to keep the process from grinding to a halt before it is completed.

The new computer model looked at the structure of the 3-D mixtures in greater detail. It showed that in mixtures where the minority cell type makes up at least 25 percent of the mix, more than 95 percent of the minority cells are in direct contact with other minority cells instead of being totally surrounded by majority cells and found that this contact enhances the surface tension effect, allowing it to drive the sorting process without assistance from cell fluctuations.


'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Related biology news :

1. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
2. New method reveals substances on surfaces of any kind
3. Biocapture surfaces produced for study of brain chemistry
4. Study of sugars on cell surface identifies key factor in flu infection
5. Its all about geometry: Protein contact surfaces hold key to cures
6. New horizons in modelling surface processes
7. Geology and biology meet in the history of US southwestern desert surface waters
8. Killer pulses help characterize special surfaces
9. Coating copies microscopic biological surfaces
10. Understanding hypertension in African Americans proves elusive
11. Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Surface tension drives segregation within cell mixtures
(Date:3/24/2017)... 2017 Research and Markets has announced the ... & Trends - Industry Forecast to 2025" report to their ... The Global ... CAGR of around 15.1% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/22/2017)... , March 21, 2017 Vigilant Solutions ... serving law enforcement agencies, announced today the appointment of ... director of public safety business development. Mr. ... enforcement experience, including a focus on the aviation transportation ... most recent position, Mr. Sheridan served as the Aviation ...
(Date:3/9/2017)... Australia , March 9, 2017 /PRNewswire/ ... at the prestigious World Lung Imaging Workshop at the ... Fouras , was invited to deliver the latest data ... This globally recognised event brings together leaders at the ... latest developments in lung imaging. "The ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... ... March 27, 2017 , ... PMG Research ... (CTC) conference presented by The Conference Forum in Boston on April 3-4, 2017. ... to drive improved clinical trial outcomes and bring them closer to the patient. Clinical ...
(Date:3/27/2017)... 2017  Trovagene, Inc. (NASDAQ: TROV), a precision medicine ... Bill Welch , will be presenting at this ... AM EDT at the Essex House in ... Scientific Officer, Mark Erlander , Ph.D., will also ... The presentation will be webcast live at ...
(Date:3/27/2017)... 2017 Neurotrope, Inc. (OTCQB: NTRP),  a ... diseases, including Alzheimer,s disease, today announced that it ... the Company,s common stock on the NASDAQ Capital ... Market, a unit of the NASDAQ OMX Group. ... Opening Bell at the NASDAQ MarketSite in Times ...
(Date:3/24/2017)... and ROCKVILLE, Md. , March 24, ... Maxwell Biotech Venture Fund (MBVF), today announced positive results ... to the standard drug therapy regimen in patients with ... molecule drug discovered by scientists at Sequella, Inc. ( ... of Health. A total of 140 ...
Breaking Biology Technology: