Navigation Links
Surface characteristics influence cellular growth on semiconductor material
Date:3/12/2014

Changing the texture and surface characteristics of a semiconductor material at the nanoscale can influence the way that neural cells grow on the material.

The finding stems from a study performed by researchers at North Carolina State University, the University of North Carolina at Chapel Hill and Purdue University, and may have utility for developing future neural implants.

"We wanted to know how a material's texture and structure can influence cell adhesion and differentiation," says Lauren Bain, lead author of a paper describing the work and a Ph.D. student in the joint biomedical engineering program at NC State and UNC-Chapel Hill. "Basically, we wanted to know if changing the physical characteristics on the surface of a semiconductor could make it easier for an implant to be integrated into neural tissue or soft tissue generally."

The researchers worked with gallium nitride (GaN), because it is one of the most promising semiconductor materials for use in biomedical applications. They also worked with PC12 cells, which are model cells used to mimic the behavior of neurons in lab experiments.

In the study, the researchers grew PC12 cells on GaN squares with four different surface characteristics: some squares were smooth; some had parallel grooves (resembling an irregular corduroy pattern); some were randomly textured (resembling a nanoscale mountain range); and some were covered with nanowires (resembling a nanoscale bed of nails).

Very few PC12 cells adhered to the smooth surface. And those that did adhere grew normally, forming long, narrow extensions. More PC12 cells adhered to the squares with parallel grooves, and these cells also grew normally.

About the same number of PC12 cells adhered to the randomly textured squares as adhered to the parallel grooves. However, these cells did not grow normally. Instead of forming narrow extensions, the cells flattened and spread across the GaN surface in all directions.

More PC12 cells adhered to the nanowire squares than to any of the other surfaces, but only 50 percent of the cells grew normally. The other 50 percent spread in all directions, like the cells on the randomly textured surfaces.

"This tells us that the actual shape of the surface characteristics influences the behavior of the cells," Bain says. "It's a non-chemical way of influencing the interaction between the material and the body. That's something we can explore as we continue working to develop new biomedical technologies."


'/>"/>

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert  

Related biology news :

1. Pacific trade winds stall global surface warming -- for now
2. Protein surfaces defects act as drug targets
3. Bioinspired and Nanoengineered Surfaces: Technologies, Applications and Global Markets
4. Sea surface temperatures reach highest level in 150 years
5. Coelacanth genome surfaces
6. A novel surface marker helps scientists fish out mammary gland stem cells
7. Monster from the deep hits the surface
8. Specialised germanium surface as universal protein adapter
9. Mutation altering stability of surface molecule in acid enables H5N1 infection of mammals
10. A cooler way to protect silicon surfaces
11. Discovering cell surface proteins behavior
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Surface characteristics influence cellular growth on semiconductor material
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... The AMA is happy to announce that $48,000 ... the nation. The scholarships are created through funds donated by model aviation organizations and ... set by the AMA Scholarship Committee, which is made up of model aviation pilots ...
(Date:4/21/2017)... ... 21, 2017 , ... Frederick Innovative Technology Center, Inc. (FITCI), ... businesses, recently earned a $77,518 grant from the Rural Maryland Council (RMC) to ... is Frederick’s first incubator. A non-profit corporation, FITCI is a public-private partnership of ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... announced their strategic partnership to offer a full spectrum of digital security goods ... suite of biometric products and the ground-breaking proactive cybersecurity services and products through ...
(Date:4/20/2017)... ... 20, 2017 , ... USDM Life Sciences , the leading risk management, ... is pleased to announce Holger Braemer as Vice President of its Europe ... in Germany. , Braemer is an integral part of USDM’s expansion of services ...
Breaking Biology Technology: