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Supportive materials will help regenerate heart tissue
Date:12/8/2009

ioengineers are proposing to use cells placed in a supportive material that changes stiffness with time by exhibiting time-dependent crosslinking.

"Our evidence suggests that tissue-specific stiffness arises from key developmental changes, which implies that cells should be cultured in the appropriate physical conditions that mimic embryonic tissue progression, from soft, pre-cardiac tissue at early embryonic age to a mature, less compliant tissue at the conclusion of development," said Jennifer Young, a Ph.D. candidate in bioengineering at UC San Diego and the first author on the peer-reviewed presentation at ASCB 2009.

By tuning this material to mimic in situ time-dependent stiffness changes, the UC San Diego bioengineers have found that cells placed in this material indicate improved cardiac differentiation.

"Results from this study may not only have a profound impact on cardiovascular engineering, but may influence the way in which many regenerative therapies are conducted. In this instance we have studied the developing tissue as a model, and from it generated a set of design criteria to mimic in our new material," said bioengineering professor Adam Engler from the UC San Diego Jacobs School of Engineering.


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Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert

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