Navigation Links
Supportive materials will help regenerate heart tissue
Date:12/8/2009

Bioengineers from University of California, San Diego are developing new regenerative therapies for heart disease. The work could influence the way in which regenerative therapies for cardiovascular and other diseases are treated in the future.

New results from UC San Diego on using adult stem cells to regenerate heart tissue in environments that mimic a human post-heart-attack heart were presented this week in San Diego at the 2009 annual meeting of the American Society for Cell Biology (ASCB). The work is from the laboratory of Adam Engler from the Department of Bioengineering at the UC San Diego Jacobs School of Engineering.

Every year in the United States, approximately 900,000 people die from heart disease. The prevalence of heart disease has prompted researchers to develop new regenerative therapies to treat the condition, including the injection of adult stem cells into the scarred heart muscle that results from a heart attack. This treatment, called cellular cardiomyoplasty, relies on injected stem cells receiving appropriate cues from their surrounding tissue to cause them to become cardiac muscle.

However, when stem cells are injected into stiff, scarred, post-heart attack muscle (rather than healthy tissue), these stem cells do not readily become cardiac muscle. In fact, only marginal improvement in overall cardiac function has been detected, and this improvement may not actually be from tissue regeneration. Instead, the improvements may be from the fact that the treatment "pokes holes" into the scar tissue and injects soft cells, making it slightly softer and thus more functional. Even more striking, the injected stem cells do not form new cardiac muscle. Instead, the stem cells form small calcified lesions. The injected stem cells are directed by the stiff scar tissue to mature into bone-like cells rather than new heart cells.

Given these problems associated with direct stem cell injection, the UC San Diego b
'/>"/>

Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Keck Foundation funds study of biological interactions with nanomaterials
2. Scientists discover record-breaking hydrogen storage materials for use in fuel cells
3. Purdue researchers obtain a snapshot clarifying how materials enter cells
4. Sea cliff erosion, hemp construction materials and more at UCSD Engineering Conference
5. Lensless camera uses X-rays to view nanoscale materials and biological specimens
6. Making sure the wonder materials dont become the wonder pollutant
7. Fast AFM probes measure multiple properties of biomolecules or materials simultaneously
8. Findings a step toward making new optical materials
9. New 3-D test method for biomaterials flat out faster
10. Research measures movement of nanomaterials in simple model food chain
11. Growing use of nanomaterials spurs research to investigate possible downsides
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Scientists at The New York Stem Cell ... to creating a viable cell replacement therapy for ... , For the first time, NYSCF scientists generated ... samples of patients with primary progressive multiple sclerosis ... induce these stem cells into becoming oligodendrocytes, the ...
(Date:7/24/2014)... ply silent freeways, solar panels blanket rooftops and power ... howling winds and from the blazing desert sun. , ... and economically feasible to convert California,s all-purpose energy infrastructure ... Energy , the plan shows the way to ... that could create tens of thousands of jobs and ...
(Date:7/24/2014)... at Albert Einstein College of Medicine of ... J. Fox Foundation for Parkinson,s Research to translate a ... This drug discovery project will test chemical compounds on ... a drug that acts on an underlying cause of ... help many people manage their symptoms, we are eager ...
Breaking Biology News(10 mins):NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 2Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 3
... organizations, educational and research institutions, and other stakeholders have ... research funding for food and agriculture. This initiative represents ... speak up in support of science for food and ... of the Joint Select Committee on Deficit Reduction (the ...
... systems are now commonly used to distribute water in many ... a plastic called cross-linked polyethylene (PEX). Are these pipes harmful ... of drinking water? Previous international studies have shown ... taste and odour to drinking water. It has also been ...
... "It is strange to think of a sea turtle as ... at the Smithsonian,s National Museum of Natural History, "but they ... skin and shells." Feuerstein is co-author of a recent ... that make a home on the bodies Olive Ridley and ...
Cached Biology News:1,200 speak up for Federal research funding for Food and Agriculture 2Survey identifies sea turtle 'hitchhikers' 2
(Date:7/24/2014)... Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the publication ... 3 study of Zerenex (ferric citrate), the Company,s investigational ... hyperphosphatemia in patients with end-stage renal disease (ESRD) on ... with FErric CiTrate in EsrD) was published online today ... Nephrology ( JASN ). , This ...
(Date:7/24/2014)... , July 24, 2014  Now available is a ... Rehealth Regenerative Therapies , located in ... physically active people a new health option: stem ... of age, countless patients suffer from joint and muscle ... as muscle tears, torn rotator cuff, tennis elbow, and ...
(Date:7/24/2014)... worldwide rely on sophisticated equipment, trained personnel, and ... areas against terrorist attacks. A revolutionary new electronic ... make their job much easier. , The groundbreaking ... Tel Aviv University ,s School of Chemistry and ... the Herzliya company Tracense, picks up the scent ...
(Date:7/24/2014)... Distinguished Professor of Engineering at the University of ... solve problems in energy engineering, environmental sustainability and ... zeolites, porous rock with a well-defined, crystalline structure. ... so precisely decided that zeolites can separate molecules ... an angstrom (one-tenth of a nanometer), making them ...
Breaking Biology Technology:Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2University of Delaware researcher describes new approach for creating organic zeolites 2
... ... software featuring new ClearTrial TRACK provides integrated planning, outsourcing, project tracking, reforecasting, accrual ... ... ClearTrial ( www.cleartrial.com ), the leading provider of Clinical Trial Operations (CTO) software, ...
... ... America has invaded the natural habitat of the western prairie fringed orchid and has caused ... are regaining the upper hand with integrated control techniques that are eliminating the leafy ... ...
... , , HOUSTON, Sept. 24 ... Browne, Chief Financial Officer, will present at the JMP Securities 4th ... 2009 at 3:30 PM EDT. JMP Securities will host a ... http://www.wsw.com/webcast/jmp9/cybx/ . The replay will be available for 90 ...
Cached Biology Technology:ClearTrial Launches Industry-first Software Platform for Integrating Clinical Trial Operations from Plan to Cash™, Driving Operational Efficiencies and Accelerating Clinical Development 2ClearTrial Launches Industry-first Software Platform for Integrating Clinical Trial Operations from Plan to Cash™, Driving Operational Efficiencies and Accelerating Clinical Development 3ClearTrial Launches Industry-first Software Platform for Integrating Clinical Trial Operations from Plan to Cash™, Driving Operational Efficiencies and Accelerating Clinical Development 4Weed Scientists Take Steps to Protect Rare Orchid 2Weed Scientists Take Steps to Protect Rare Orchid 3Cyberonics to Present at JMP Securities 4th Annual Healthcare Focus Conference 2