Navigation Links
Supplement may prevent alcohol-related brain, skull defects
Date:5/27/2010

AUGUSTA, Ga. The dietary supplement CDP-choline, sold as a brain-boosting agent and under study for stroke and traumatic brain injury, may block skull and brain damage that can result from alcohol consumption early in pregnancy, Medical College of Georgia researchers report.

Alcohol consumption in early pregnancy increases levels of a little-known lipid called ceramide, significantly increasing suicide among cells critical to skull and brain formation, Dr. Erhard Bieberich, biochemist in the MCG Schools of Graduate Studies and Medicine, reports in Cell Death and Disease.

Resulting neural crest damage includes the brain's "skin" the multi-layered meninges that provides protection and nourishment producing less TGF-β1, a growth factor critical for brain and bone development. That finding may help explain the cranial bone and cognitive defects that can result in fetal alcohol syndrome.

"There is just a little window," Bieberich said, about four weeks after conception when neural crest cells emerge for a few days before morphing into other cell types that help form numerous organs. This is often before a woman knows she is pregnant. The studies indicate the potential for lasting damage to the fetus if a woman drinks, for example, several glasses of wine within an hour during that window.

MCG researchers suspected ceramide, known to induce cell death and be activated by alcohol, as a culprit in the damage. They found high levels of ceramide both in mouse cells and pregnant mice exposed to alcohol along with a five-fold increase in apoptotic, or dying cells. "There is a clear correlation," he said.

Researchers thought neural crest cells were tough cells whose function could be replaced if they happened to get injured. Instead they found that 25 percent of mouse embryos exposed to alcohol during that critical period had defects in the fibrous joints that connect the skull. "You get a snowball effect: The neural crest is damaged, the meninges doesn't develop properly and tissue like bone and brain that are regulated by the meninges don't develop properly either," Bieberich said.

When they added ceramide-neutralizing CDP-choline to the mouse cells, cell death and ceramide levels were reduced. Alcohol prompts the body to produce more ceramide from the brain lipid sphingomyelin, a major component of cell membranes. They found that CDP-choline pushes back toward producing less ceramide, preventing damage providing the drinking stops.

"Ceramide can be bad or good," notes Bieberich, who has shown, for example, ceramide's role in helping early stem cells evolve into embryonic tissue. But alcohol upsets the natural balance.

Follow up studies, funded by the March of Dimes, include determining whether CDP-choline can rescue cells after the fact or whether it or a similar supplement would need to be taken preventively. "Hopefully we can rescue some of the cells by triggering or signaling the back reaction," Bieberich said. He also wants to see if CDP-choline affords the same protection in pregnant mice that it does in laboratory cells.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. Market testing of dietary supplements and drugs underscores value of USPs public health programs
2. Unique whey protein is promising supplement for strict PKU diet
3. Blueberry and green tea containing supplement protects against stroke damage
4. Supplements are not nutritious
5. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
6. Wellmune WGP supplementation alleviates
7. People with diabetes may have all natural citrus supplement
8. A nutritional supplement could improve the clinical situation of ICU patients
9. Researchers identify cancer preventive properties in common vitamin supplement
10. L-1 Identity Solutions to Hold Supplemental Second Quarter 2008 Financial Results Q&A Conference Call at 2:00p.m. (ET) Today
11. The dietary supplement genistein can undermine breast cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Supplement may prevent alcohol-related brain, skull defects
(Date:1/7/2016)... NEW YORK , Jan. 7, 2016 ... as regional markets for biometric technologies and devices, identifying ... application market for various types of biometric devices. Includes ... report to: Identify newer markets and explore the ... of biometric devices. Examine each type of biometric technology, ...
(Date:1/7/2016)... -- A United States District Court in Illinois ... to interpret a biometric privacy statute in a decision ... photo website Shutterfly brought by the law firm Carey Rodriguez ... SHUTTERFLY, INC.; and THISLIFE, INC ( N.D. Ill ., ... Illinois Biometric Privacy Act by collecting and scanning face ...
(Date:1/6/2016)... Jan. 6, 2016 Based on its ... & Sullivan recognizes MorphoTrak, LLC, a U.S. subsidiary ... Frost & Sullivan Company of the Year Award. ... technology, Morpho Wave™ , has consolidated the company,s ... biometrics market. Morpho Wave is a highly ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016 On Thursday, February ... information source for community, health and disaster services, and ... will integrate to enhance care coordination and service delivery ... services they need and to better connect service providers ... San Diego has handled ...
(Date:2/4/2016)... , Feb. 4, 2016  Sangamo BioSciences, Inc. ... editing, announced today that Edward Lanphier , Sangamo,s ... on the progress of Sangamo,s ZFP Therapeutic ® ... strategy at 2:40 pm ET on Thursday, February 11, ... Global Healthcare Conference. The conference is being held in ...
(Date:2/4/2016)... MENLO PARK, Calif. , Feb. 4, 2016   ... a biopharmaceutical company focused on the development and commercialization of ... the 18 th Annual BIO CEO & Investor ... EST in New York, NY . ... provide an update on the ongoing clinical trial of ...
(Date:2/4/2016)... ... February 04, 2016 , ... Franz ... Semantic Graph Database technology has been recognized As “ Best in Semantic Web ... Magazine. , “At Corporate America, it’s our priority to showcase prominent professionals who ...
Breaking Biology Technology: