Navigation Links
Superbugs may have a soft spot, after all
Date:2/26/2013

The overuse of antibiotics has created strains of bacteria resistant to medication, making the diseases they cause difficult to treat, or even deadly. But now a research team at the University of Rochester has identified a weakness in at least one superbug that scientists may be able to medically exploit.

Biologists Gloria Culver at Rochester and Keith Connolly, now at Harvard University, thought one key to stopping the bacteria may lie with proteins, so they studied the mechanism behind the development of bacterial ribosomesthe cell's protein-manufacturing machine.

"We targeted the ribosomes in our research because cells and organisms can't live if they don't make proteins, and they can't make proteins if their ribosomes aren't functioning properly." said Culver.

Culver and Connolly specifically worked with cultures of E. coli, a bacteria commonly found in the intestines. While E. coli is usually harmless, some strains are resistant to antibiotics and can cause serious food poisoning.

They discovered that two proteins already present in E. coli cellsRbfA and KsgAneed to be in balance with each other in order for ribosomes to function. If those proteins are present in the wrong concentrations, the ribosomes will not mature properly and will be unable to produce proteins, leading to the death of the cells. Their findings are being published this week in the journal Molecular Microbiology.

Culver said with the discovery that KsgA and RbfA.must be balanced for the cells to function properly, the next goal is to determine an effective way to disrupt that balance.

Crucially, RbfA does not exist in humans. "That may make it possible," Culver said," to kill E. coli without having a harmful effect on people."

Eric Brown, a professor of biochemistry and biomedical sciences at McMaster University in Hamilton, Ont., calls their work creative and scholarly. "Ribosome assemb
'/>"/>

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hunt for superbugs in Australian animals
2. Hydrogen peroxide vapor enhances hospital disinfection of superbugs
3. 1 year after Fukushima
4. AGU: Venice hasnt stopped sinking after all
5. Black flies may have a purpose after all
6. Estrogen hormone reveals protective ability after traumatic brain injury
7. Obstructive sleep apneas damage evident after 1 month
8. Scientists read the ash from the Icelandic volcano 2 years after its eruption
9. Microbial communities shifted dramatically after Deepwater Horizon spill
10. Regenerated cells may restore vision after corneal dysfunction
11. Cinega de Santa Clara unchanged after pilot run of Yuma Desalting Plant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/9/2015)... 9, 2015 Synaptics Inc. (NASDAQ: SYNA ), ... that it will report financial results for the third ... after the close of market. The company will host ... 2:00 p.m. PT (5:00 p.m. ET), during which management ... on the live call, analysts and investors should dial ...
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/143028 for MINIATURE, MULTI-PURPOSE ... TRANSFER  NXT-ID introduces a new revolutionary ... patent surrounds the use of miniature antenna modules ...
(Date:4/2/2015)... Md. , April 2, 2015 At ... Salt Lake City , the American College ... of five new directors to its Board.  Members of ... the ACMG and for forming and advancing its policies ... medical genetics profession. "It,s an eventful time ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... adopts an unusual shape called Z-DNA, it can lead to ... leukemia and lymphoma, according to a study by researchers at ... , The study, issued in advance of the Feb. 21 ... demonstrates for the first time that the oddly shaped DNA ...
... individuals of many fish species face a developmental choice ... a sedentary or migratory lifestyle. , Sedentary (or ... while their migratory compatriots set forth on long open-water ... "life history" is known to be influenced by environmental ...
... restricting antibiotic use in food-producing animals may be linked ... citizens, according to an article in the May 15 ... , Campylobacter jejuni is a leading bacterial cause of ... Campylobacter infections difficult for physicians to treat, and can ...
Cached Biology News:When good DNA goes bad 2When good DNA goes bad 3For some young fish, early gene expression is a clear harbinger of fated lifestyle 2Less antibiotic use in food animals leads to less drug resistance in people, study shows 2
(Date:4/16/2015)... , April 16, 2015  EMD Serono today ... Darmstadt, Germany , appointed ... Head of Global Clinical Development.  Dr. Reicin brings ... experience in Oncology and Immunology. She is an ... served as a Vice President in various capacities ...
(Date:4/16/2015)... MENLO PARK, Calif. , April 16, 2015 /PRNewswire/ ... the Company), a biopharmaceutical company focused on developing and ... today announced that the Mayo Clinic Cancer Center ... for the ongoing, multicenter Phase I/II study of VAL-083 ... common and deadly form of human brain cancer. ...
(Date:4/16/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ... DCVax® personalized immune therapies for cancer, announced today ... Cancer Immunotherapy Index (LCINDX), a professional index recently ... field within the biotechnology space.  ... companies" in the immunotherapy space, including 6 big ...
(Date:4/16/2015)... Tex. (PRWEB) April 16, 2015 ... chain management systems for highly regulated industries, is ... been name a monthly columnist for Cold Chain ... ( http://www.coldchainiq.com ). His column titled, Global Cold ... chain information for today’s life sciences, pharmaceutical and ...
Breaking Biology Technology:Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 2DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 4DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 5NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3Modality Solutions Gary Hutchinson Named Columnist for Cold Chain IQ 2Modality Solutions Gary Hutchinson Named Columnist for Cold Chain IQ 3
... , PHILADELPHIA, Aug. 26 ERT (Nasdaq: ... Associate Director of Business Development - Japan, Miki Stevens. In ... partner, Site Support Institute (SSI), to facilitate sales activities and ... trial sites. By nurturing existing strategic partnerships, Ms. Stevens will ...
... ... community to obtain relevant information and accuracy beyond Search Engine Optimization , ... Malaga, Spain (Vocus) August 26, ... software solutions, will present on September 1st at the Association for Medical Education ...
... , , ... it has received 510K Clearance from the FDA for its ... the device in the United States. Aixplorer is the ... which is based upon interaction between conventional longitudinal waves and ...
Cached Biology Technology:ERT Appoints New Associate Director of Business Development - Japan 2ERT Appoints New Associate Director of Business Development - Japan 3iSEEK Enterprise Presents Collaboration with Penn Medicine at 2009 AMEE Conference 2SuperSonic Imagine Receives FDA Approval for Aixplorer Ultrasound System 2SuperSonic Imagine Receives FDA Approval for Aixplorer Ultrasound System 3SuperSonic Imagine Receives FDA Approval for Aixplorer Ultrasound System 4