Navigation Links
Superbright and fast X-rays image single layer of proteins
Date:2/14/2014

ironment.

To get a clearer view of protein monolayers using XFEL, the team will need to improve the resolution to 1 to 3 angstroms, as well as take images of the proteins at angles, efforts that are currently underway.

Not Your Family's Crystal

Researchers have been using X-ray crystallography for more than 60 years to determine the shape and form of proteins that form the widgets and gears of a living organism's cells. The conventional method requires, however, that proteins stack into a large crystal, similar to how oranges stack in a crate. The structure of more than 80,000 proteins have been determined this way, leading to breakthroughs in understanding of diseases, pathogens, and how organisms grow and develop.

But many proteins found in nature do not stack easily. Some jut from the fatty membranes that cover cells, detecting and interacting with other cells and objects, such as viruses or bacteria, in the surrounding area. These proteins are not used to having others of their kind stack on top. These so-called membrane proteins make up about 25 percent of all proteins, but only 2 percent of proteins that researchers have determined structures for.

Wafer Thin

Researchers in the last decade have been pursuing the idea that one sheet of proteins could be visualized if the X-rays were bright enough and flashed on and off quickly enough to limit the damage. Two years ago, scientists demonstrated they could use XFEL technology on crystals of proteins about 15 to 20 sheets thick.

Evans, Frank and their team wanted to push this further. The team worked on a way to create one-sheet-thick crystals of two different proteins -- a protein called streptavidin and a membrane protein called bacteriodopsin. The structures of both proteins are well-known to scientists, which gave the team something to compare their results to.

The team shined the super-bright X-rays for a brief moment -- abou
'/>"/>

Contact: Mary Beckman
mary.beckman@pnnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. X-rays reveal uptake of nanoparticles by soya bean crops
2. Scientists reassemble the backbone of life with a particle acceleratorynchrotron X-rays
3. X-rays reveal the self-defence mechanisms of bacteria
4. Dental X-rays linked to common brain tumor
5. Graphene sandwich improves images of biomolecules
6. Capturing ultrasharp images of multiple cell components at once
7. Image or reality? Leaf research needs photos and lab analysis
8. Scientists uncover image of muscular dystrophy defect & design targeted drug candidates
9. ASU researchers develop new device to help image key proteins at room temperature
10. Neurons subtract images and use the differences
11. Aware Supplies Saudi Arabia with Biometrics Software to Help Facilitate Pilgrimage Travel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Superbright and fast X-rays image single layer of proteins
(Date:7/31/2014)... Bureau, Latinos are the largest minority group in the ... one-third of Latinos are obese and are 1.2 times ... , NYU College of Nursing student researcher Lauren ... the factors that contribute to this problem by compiling ... food patterns in Latina women recently published in ...
(Date:7/31/2014)... (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity ... (HPV) vaccine Cervarix. Women vaccinated with the ... than nine years, and vaccine efficacy (VE) ... the longest follow-up report for a licensed ... the full paper. , HPV and ...
(Date:7/31/2014)... An international team of scientists from Spain, France, ... rove beetle that is the oldest definitive member ... found in amber. The discovery and description were ... phase-contrast X-ray synchrotron imaging technique, which allows the ... amber. The new species is described in the ...
Breaking Biology News(10 mins):NYU research looks to combat US Latina immigrant obesity 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3
... The second annual Epigenetic Control and Cellular Plasticity ... remodeling contribute to various processes that lead to cellular ... 12-13, at the At the Beckman Center of the ... INFORMATION: Media planning to attend should ...
... concern over possible large and rapid changes in the physical ... oceans. Some of these changes could occur within a ... and ecosystems to adapt. A new report from the ... stating that even steady, gradual change in the physical climate ...
... the Hebrew university of Jerusalem and the startup company ... diseases. The researchers found that TyrNovo,s novel and unique ... in order to protect the brain from neurodegenerative diseases, ... step towards the development of future drugs for the ...
Cached Biology News:Top scientists to present at Epigenetic Control and Cellular Plasticity symposium 2New report calls for attention to abrupt impacts from climate change 2New report calls for attention to abrupt impacts from climate change 3New compound for slowing the aging process can lead to novel treatments for brain diseases 2New compound for slowing the aging process can lead to novel treatments for brain diseases 3
(Date:8/1/2014)... Once a decision has been made to increase ... how to define your tolerance for lowest cost design ... Director of Facilities Integration at Fluor Industrial Services, Craig ... and special guest Carrier Li, Director in Global Asset ... provide an examination of the Conceptual Design process and ...
(Date:7/31/2014)... City, CA (PRWEB) July 31, 2014 ... as consumers, are increasingly searching for food alternatives ... and nutritional benefits. The food ingredient market has ... budding players such as Vital Force Technology (VFT). ... with more than 4,000 energetic patterns, all tested ...
(Date:7/31/2014)... British mathematician (1912-1954), is famous for a number of ... In 1936 he published a paper, which laid the ... of a computer algorithm. He next played a pivotal ... which cracked the German military codes, enabling the Allies ... in the late 1940,s he turned his attention to ...
(Date:7/31/2014)... New York , July 31, 2014 ... by Transparency Market Research "Quantum Dots Market - Global ... - 2023," the market was valued at USD 88.5 ... 8,246.8 million by 2023, growing at a CAGR of ... full Quantum Dots Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html ...
Breaking Biology Technology:Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4
... 4 Immtech Pharmaceuticals,Inc. (AMEX: IMM ) ... exclusive,license to BioAlliance Pharma SA (Euronext Paris - ... maleate (pafuramidine), in,Europe for the treatment of pneumocystis ... of Human African trypanosomiasis, also known as,African sleeping ...
... Israel, December 4 Healthcare,Technologies Ltd. (NASDAQ: ... its unaffiliated and voting shareholders (approximately 90%),voted in ... the meeting, the shareholders were asked to approve ... Inc, Mac,Bioventures Inc. and Gamida for Life B.V. ...
... Biotest Pharmaceuticals,Corporation, a leading developer of ... management team as part of the formal,completion ... (Nasdaq:,NABI) and the creation of Biotest Pharmaceuticals. ... Corporation Completes Acquisition,of Nabi Biologics Business Unit," ...
Cached Biology Technology:Immtech and BioAlliance Sign Licensing Agreement for Pafuramidine 2Immtech and BioAlliance Sign Licensing Agreement for Pafuramidine 3Immtech and BioAlliance Sign Licensing Agreement for Pafuramidine 4Healthcare Announced That an Overwhelming Majority of its Shareholders Approved the NexGen Biofuels Transaction 2Biotest Pharmaceuticals Corporation Announces Management Team 2Biotest Pharmaceuticals Corporation Announces Management Team 3
... Thermo has established an expertise in ... both for solid support synthesis and synthesis ... controlled by Mass Spectrometry and analytical HPLC ... provide products that meet the highest quality ...
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... dispensers save space and organize ... and other garb. They are ... for small parts used in ... acrylic. Many other sizes and ...
Biology Products: