Navigation Links
Super-sleepers could help super-sizers!
Date:6/28/2009

Many species of animals go through a period of torpor to conserve energy when resources are scarce. But when it comes to switching to energy-saving mode, the champion by far among vertebrates is the burrowing frog (Cyclorana alboguttata), which can survive for several years buried in the mud in the absence of any food or water. How do they accomplish this feat? A team of scientists at the University of Queensland have discovered that the metabolism of their cells changes radically during the dormancy period allowing the frogs to maximise the use of their limited energy resources without ever running on empty. This discovery could prove to have important medical applications in the long term. "It could potentially be useful in the treatment of energy-related disorders such as obesity", explains Ms. Sara Kayes who will present her findings at the Society of Experimental Biology Annual Meeting in Glasgow on Monday 29th June 2009.

When the operation efficiency of the mitochondria, the tiny "power plants" of the cell, was measured during the dormancy period, it was found to be significantly higher compared to that observed in active animals. This trick , known as mitochondrial coupling, allows these frogs to be extremely efficient in the use of the limited energy stores they have by increasing the total amount of energy obtained per unit consumed, allowing them to easily outperform other species whose energy production efficiency remains essentially the same even when they happen to be inactive for extended periods.

If this is such an efficient way to use energy resources during dormancy, how come that it is not more widespread in the animal kingdom? The researchers speculate that a potential drawback may be the increased production of reactive oxygen species, which may in turn lead to oxidative stress. Since these small molecules are believed to cause most of the damage during periods of re-awakening, increasing mitochondrial coupling does not seem to be a particularly good idea for animals that tend to exhibit short periods of spontaneous arousal during the dormancy period, in some cases even daily. Burrowing frogs, on the other hand, are believed to remain deeply asleep during the entire period of dormancy. Furthermore, being cold-blooded, they don't have the need to maintain a basal level of heat production, minimizing their energy needs.


'/>"/>

Contact: Cristian C. A. Bodo
Cristian.Bodo@kcl.ac.uk
44-794-258-7047
Society for Experimental Biology
Source:Eurekalert  

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Obesity and lack of exercise could enhance the risk of pancreatic cancer
3. Finding that 1-in-a-billion that could lead to disease
4. 60 second test could help early diagnosis of common brain diseases
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Paracetamol, one of most used analgesics, could slow down bone growth
7. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
8. Thousands of starving children could be restored to health with peanut butter program
9. Nanotech could make solar energy as easy and cheap as growing grass
10. CO2 emissions could violate EPA ocean-quality standards within decades
11. MIT model could improve some drugs effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Super-sleepers could help super-sizers!
(Date:4/4/2017)... April 4, 2017   EyeLock LLC , a ... the United States Patent and Trademark Office (USPTO) has ... the linking of an iris image with a face ... represents the company,s 45 th issued patent. ... very timely given the multi-modal biometric capabilities that have ...
(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. ... San Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, ... government officials from around the world to address key issues in device compliance, quality ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
Breaking Biology Technology: