Engineered self-assemblies used in nanomedicine come in over five groups of structural shapes, including the micellar nanostructure.
"We have recently developed a novel strategy that utilizes micelles self-assembled from recombinant polypeptides after attaching doxorubicin, a cancer drug, to deliver the drug," explained Dr. Chilkoti, who is also the director of the Duke University Center for Biologically Inspired Materials and Material Systems.
According to Dr. MacKay, a co-corresponding author of the report, the stability of micelles is important to their success or failure as drug delivery systems.
"The stability of micelles has thermodynamic and kinetic components," he said. "All factors that influence micellar stability can be tuned at the genetic level. Thus, we believe that genetically encoded polypeptide micelles are likely to play an increasing role in the design of next generation nanoscale carriers of drug and imaging agents."
In their report, the authors evaluate the structural and physiochemical properties, as well as the potential applications, of each type of structure.
|Contact: Randolph Fillmore|
University of South Florida (USF Health)