Navigation Links
Super-mini vehicles carry therapeutics and imaging agents into body with mega results
Date:6/7/2011

Measured in billionths of a meter, self-assembling nano-sized devices designed to carry drugs and imaging agents into the body are revolutionizing medicine by improving drug solubility and bio-distribution, providing a platform for combining targeting and imaging agents, and enabling membrane barriers to be crossed as well as making drug and imaging agent combination therapies possible.

Self-assembling nano devices are now enlisted in the nanomedicine revolution, a story as told by researchers from Duke University and the University of Southern California in an article in the current TECHNOLOGY & INNOVATION, Proceedings of the National Academy of Inventors . (http://www.ingentaconnect.com/content/cog/ti/2011/00000013/00000001)

Their report covers two classes of self-assembled, nanoscale medical delivery devices currently used to transport drugs and also imaging materials across physiological barriers that they, acting by themselves, would be unable to cross.

"Nanoscale self-assembly devices are complex structures organized from simpler subcomponents - either naturally occurring or engineered - which assume complex structures difficult to attain by chemical synthesis," said the paper's corresponding author Dr. Ashutosh Chilkoti, professor of biomedical engineering at Duke University. "Their disassociation can be triggered by external stimuli, which serve as mechanisms to release therapeutic payloads."

According to Dr. Chilkoti and his co-authors, Dr. Mingan Chen and Jonathan R. McDaniel of the Duke University Department of Biomedical Engineering, as well as Dr. J. Andrew MacKay of the University of Southern California Department of Pharmacology and Pharmaceutical Sciences, many biological events rely on structures that self-assemble or disassemble based on environmental changes or physiological needs. Such natural self-assemblies used in nanomedicine rely on multiple weak forces, such as those associated with viral capsids and proteins.

Engineered self-assemblies used in nanomedicine come in over five groups of structural shapes, including the micellar nanostructure.

"We have recently developed a novel strategy that utilizes micelles self-assembled from recombinant polypeptides after attaching doxorubicin, a cancer drug, to deliver the drug," explained Dr. Chilkoti, who is also the director of the Duke University Center for Biologically Inspired Materials and Material Systems.

According to Dr. MacKay, a co-corresponding author of the report, the stability of micelles is important to their success or failure as drug delivery systems.

"The stability of micelles has thermodynamic and kinetic components," he said. "All factors that influence micellar stability can be tuned at the genetic level. Thus, we believe that genetically encoded polypeptide micelles are likely to play an increasing role in the design of next generation nanoscale carriers of drug and imaging agents."

In their report, the authors evaluate the structural and physiochemical properties, as well as the potential applications, of each type of structure.


'/>"/>

Contact: Randolph Fillmore
rfillmore@nasw.org
University of South Florida (USF Health)
Source:Eurekalert

Related biology news :

1. Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics
2. Chasing tiny vehicles
3. Ethanol-powered vehicles generate more ozone than gas-powered ones
4. ORNL strengthens DOE-funded clean vehicles team
5. UW leading $7.5 million study of animal flight and aerial vehicles
6. Earthworm activity can alter forests carbon-carrying capabilities
7. Polarized light guides cholera-carrying midges that contaminate water supplies
8. Weizmann Institute scientists show extra copies of a gene carry extra risk
9. Dust deposited in oceans may carry elements toxic to marine algae
10. Gorillas carry malignant malaria parasite, study reports
11. Tool use in an invertebrate: The coconut-carrying octopus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
(Date:3/23/2016)... 23, 2016 ... Gesichts- und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler ... mit SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie ... die Möglichkeit angeboten, im Rahmen mobiler Apps ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight Medical ... to the healthcare market. The company's primary focus is on new product introductions, ... strategies that are necessary to help companies efficiently bring their products to market. ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
Breaking Biology Technology: