Navigation Links
Sunlight can influence the breakdown of medicines in the body
Date:3/9/2011

A study from the Swedish medical university Karolinska Institutet has shown that the body's ability to break down medicines may be closely related to exposure to sunlight, and thus may vary with the seasons. The findings offer a completely new model to explain individual differences in the effects of drugs, and how the surroundings can influence the body's ability to deal with toxins.

The study will be published in the scientific journal Drug Metabolism & Disposition and is based on nearly 70,000 analyses from patients who have undergone regular monitoring of the levels of drugs in their blood. The drugs taken by these patients are used to suppress the immune system in association with organ transplants. Samples taken during the winter months were compared with those taken late in the summer.

A more detailed analysis showed that the concentrations of drugs such as tacrolimus and sirolimus, which are used to prevent rejection following transplantation, vary throughout the year in a manner that closely reflects changes in the level of vitamin D in the body. The ability of the body to form vitamin D depends on sunlight, and the highest levels in the patients taking part in the study were reached during that part of the year when the levels of the drugs were lowest.

The connection between sunlight, vitamin D and variations in drug concentration is believed to arise from the activation by vitamin D of the detoxification system of the liver by increasing the amount of an enzyme known as CYP3A4. This enzyme, in turn, is responsible for the breakdown of tacrolimus and sirolimus.

"If the breakdown capacity increases, then higher doses of a drug are normally required in order to achieve the same effect. More research will be needed to confirm the results, but CYP3A4 is considered to be the most important enzyme in drug turnover in the body, and the results may have significance for many drugs", says Jonatan Lindh at the Department of Laboratory Medicine and one of the scientists who carried out the study.

The effects of vitamin D on CYP3A4 have previously been demonstrated in experiments in cell cultures. But the study now to be published shows for the first time that the mechanism can play an important role in the pharmacological treatment of patients, and it shows for the first time that variation in exposure to sunlight may affect the sensitivity of individuals to drugs.


'/>"/>

Contact: Press Officer Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related biology news :

1. Tall order sunlight-to-hydrogen system works, neutron analysis confirms
2. Scientists clock on to how sunlight shapes daily rhythms
3. Exposure to early evening sunlight in spring creates teenage night owls
4. California team to receive up to $122 million to develop method to produce fuels from sunlight
5. Early Earth absorbed more sunlight -- no extreme greenhouse needed to keep water wet
6. Study explores link between sunlight, multiple sclerosis
7. Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss
8. The sunlight solution for better health
9. Turning sunlight into liquid fuels
10. The undead may influence biodiversity, greenhouse gas emissions
11. Molecular network influences development of chronic lymphocytic leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... Report Highlights The global biosurgery ... billion in 2016 at a compound annual growth rate ... Includes - An overview of the global market for ... from 2015 and 2016, and projections of compound annual ... market on the basis of product type, source, application, ...
(Date:2/6/2017)... According to Acuity Market Intelligence, ongoing ... to continue to embrace biometric and digital identification ... Border Control (ABC) eGates and 1436 Automated Passport ... 163 ports of entry across the globe. Deployments ... combined CAGR of 37%. APC Kiosks reached 75% ...
(Date:2/2/2017)... , Feb. 2, 2017  EyeLock LLC, a ... a new white paper " What You Should Know ... problem of ensuring user authenticity is a growing concern. ... authentication of users. However, traditional authentication schemes such as ... Biometric authentication offers an elegant solution to ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... Scientists propose in Nature blocking ... Gaucher and maybe other lysosomal storage diseases as a ... current therapies. An international research team led ... also included investigators from the University of Lübeck in ... 22. The study was conducted in mouse models of ...
(Date:2/22/2017)... ... February 22, 2017 , ... ProMIS Neurosciences (“ProMIS” or ... neurodegenerative diseases, today announced it has issued a scientific white paper entitled “Results ... a series of commentaries from ProMIS’s scientific team offering insight into the Company’s ...
(Date:2/22/2017)... ... February 22, 2017 , ... LabRoots , the leading provider of ... world, is pleased to announce the launch of a new scholarship for young scientists ... , This merit-based scholarship is open to all high school seniors, 17 years or ...
(Date:2/22/2017)... 22, 2017 Origin (Origin Agritech, LLC, a subsidiary of ... provider, and Arcadia (Arcadia Biosciences, Inc., NASDAQ: ... commercializes agricultural productivity traits and nutritional products, today announced their collaboration ... developed in China to the ... ...
Breaking Biology Technology: