Navigation Links
Sugar substance 'kills' good HDL cholesterol, new research finds
Date:8/31/2014

Scientists at the University of Warwick have discovered that 'good' cholesterol is turned 'bad' by a sugar-derived substance.

The substance, methylglyoxal - MG, was found to damage 'good' HDL cholesterol, which removes excess levels of bad cholesterol from the body.

Low levels of HDL, High Density Lipoprotein, are closely linked to heart disease, with increased levels of MG being common in the elderly and those with diabetes or kidney problems.

Supported by funding from the British Heart Foundation (BHF) and published in Nutrition and Diabetes, the researchers discovered that MG destabilises HDL and causes it to lose the properties which protect against heart disease.

HDL damaged by MG is rapidly cleared from the blood, reducing its HDL content, or remains in plasma having lost its beneficial function.

Lead researcher Dr Naila Rabbani, of the Warwick Medical School, says that: "MG damage to HDL is a new and likely important cause of low and dysfunctional HDL, and could count for up to a 10% risk of heart disease".

There are currently no drugs that can reverse low levels of HDL, but the Warwick researchers argue that by discovering how MG damages HDL has provided new potential strategies for reducing MG levels.

Commenting on the research's implications Dr Rabbani said:

"By understanding how MG damages HDL we can now focus on developing drugs that reduce the concentration of MG in the blood, but it not only be drugs that can help.

"We could now develop new food supplements that decrease MG by increasing the amount of a protein called glyoxalase 1, or Glo 1, which converts MG to harmless substances.

"This means that in future we have both new drugs and new foods that can help prevent and correct low HDL, all through the control of MG."

A potentially damaging substance, MG is formed from glucose in the body. It is 40,000 times more reactive than glucose it damages arginine residue (amino acid) in HDL at functionally important site causing the particle to become unstable.

Glo1 converts MG to harmless substances and protects us. MG levels are normally kept low in the body to maintain good health but they slowly increase with ageing as Glo1 slowly becomes worn out and is only slowly replaced.

Dr Rabbani says: "We call abnormally high levels of MG 'dicarbonyl stress'. This occurs in some diseases particularly diabetes, kidney dialysis, heart disease and obesity. We need sufficient Glo1 to keep MG low and keep us in good health."


'/>"/>

Contact: Tom Frew
a.t.frew@warwick.ac.uk
44-024-767-75910
University of Warwick
Source:Eurekalert  

Related biology news :

1. Team aims to make sugarcane, sorghum into oil-producing crops
2. Glycemic index foods at breakfast can control blood sugar throughout the day
3. New study: Snacking on raisins significantly reduces overall post-meal blood sugar levels
4. Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
5. Sugar-sweetened drinks are not replacing milk in kids diets
6. Blood sugar diabetes risk for South Asians
7. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
8. Boosting galactan sugars could boost biofuel production
9. New study finds neither HFCS nor table sugar increases liver fat under real world conditions
10. Organic tomatoes accumulate more vitamin C, sugars than conventionally grown fruit
11. Kids consumption of sugared beverages linked to higher caloric intake of food
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sugar substance 'kills' good HDL cholesterol, new research finds
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... ... largest Asian exhibitions for analytical and scientific instruments. This year’s symposium, organized by ... Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss novel ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, ... modular downlights designed to stay tightly sealed and perform efficiently for years. The ... wet location listings just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; ...
(Date:8/15/2017)... ... August 15, 2017 , ... Coffea arabica ... biotic and abiotic factors. During this educational webinar, participants will learn about the ... as gain a better understanding of how genomics is important for coffee breeding ...
(Date:8/14/2017)... ... 14, 2017 , ... Every year, millions of dollars are ... community have recently come together to address this antibody crisis and develop standards ... , The team at Thermo Fisher Scientific has arranged for an ...
Breaking Biology Technology: