Navigation Links
Sugar on bacteria surface serves as base for a web of resistance
Date:4/21/2009

o occupy a new surface and begin matrix and biofilm development all over again. The cell death is also believed to be the source of the extracellular DNA that helps maintain the biofilm structure during this release of seed cells.

"We all think of DNA as an information storage element in our cells, but it's becoming clear that DNA has roles outside of that capacity," Wozniak said.

Wozniak and colleagues introduced a number of mutant genes and enzymes to the process to either block or generate extra Psl to test its role in matrix formation. All signs point to Psl as the key scaffolding component of the Pseudomonas biofilm matrix, he said.

It's too early to tell whether strategies to block Psl in these lab experiments would be a safe way to disrupt the polysaccharide's actions in the human body, Wozniak noted.

Surfaces to which bacterial biofilms can attach are key to their success, meaning that in addition to thriving in congested lungs, they also grow on catheters, ventilators and tracheal tubes any medical device that enters the body. But preventing bacterial biofilm development has implications beyond medicine.

Fortified by the moist environment, plentiful nutrients and easy access to the human mouth, biofilms are also responsible for tooth decay. These microcolonies, when they are able to contact water or soil, also attach to certain industrial surfaces, causing corrosion and other damage.

"Not all bacteria use biofilms, but many do," Wozniak said. "Biofilms have been recognized for some time, but only in the last decade have people been able to apply modern molecular techniques to address the problem."


'/>"/>

Contact: Daniel Wozniak
daniel.wozniak@osumc.edu
614-247-7629
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Nutrition experts propose new class of low-sugar drinks to help stem obesity and diabetes epidemics
2. Spun-sugar fibers spawn sweet technique for nerve repair
3. High blood sugars impact on immune system holds clues to improving islet cell transplants
4. Engineering algae to make fuel instead of sugar
5. Genes determine whether sugar pills work
6. A spoonful of sugar?
7. Master gene plays key role in blood sugar levels
8. Acrylic glass made of sugar
9. Apelin hormone injections powerfully lower blood sugar
10. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
11. New process derives green gasoline from plant sugars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... while feeding a world population predicted to reach ... approach to conservation that considers human-altered landscapes such ... and the natural habitat that supports it might ... where at least three-quarters of the land surface ... is vulnerable to human-caused impacts such as climate ...
(Date:4/18/2014)... to the story of how barnyard chickens came to be, ... journal Proceedings of the National Academy of Sciences . ... 200-2300 years ago in Europe, researchers report that just a ... different from the chickens we know today. , The results ... domestic chickens -- such as their yellowish skin -- only ...
(Date:4/18/2014)... Asteroid and comet impacts can cause widespread ecological ... even global scales. But new research from Brown University ... ancient life at the time of an impact. , ... has found fragments of leaves and preserved organic compounds ... in Argentina. The material could provide a snapshot of ...
Breaking Biology News(10 mins):Stanford researchers rethink 'natural' habitat for wildlife 2Stanford researchers rethink 'natural' habitat for wildlife 3Stanford researchers rethink 'natural' habitat for wildlife 4Ancient DNA offers clues to how barnyard chickens came to be 2Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3
... form of skin cancer, can be successfully treated in some ... work and why they are only effective in some patients ... articles in the January 17 issue of the Journal of ... of immune cells called killer T cells that can attack ...
... with high-risk breast cancer treated with radical mastectomy and ... better survival outcomes with few long-term toxic effects, according ... appears in the January 19 issue of the Journal ... randomized radiation therapy trial was designed to determine the ...
... results of a recent U.S. study, investigators in Japan ... potentially life-threatening form of high blood pressure, as reported ... Infectious Diseases, now available online. , The researchers reported ... 8 (HHV-8), also known as the Kaposi's sarcoma virus, ...
Cached Biology News:Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer 2Association of herpesvirus with lung disorder questioned 2
(Date:1/14/2014)... January 14, 2014 Histogen, Inc., a ... of cells grown under simulated embryonic conditions, today announced ... with Suneva Medical, Inc. for physician-dispensed aesthetic products containing ... , This agreement is an amendment to the existing ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 EquitiesIQ, a ... Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical company ... the wound care market. , Free report download: ... with a seasoned management team and Board, which launched ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), a ... for patients, physicians, the biopharmaceutical industry, regulators, payers, ... signing of a three-year Research Collaboration Agreement (RCA) ... This initiative is designed to generate disruptive ...
Breaking Biology Technology:Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... Newly formed Advisory Board to advise on cancer screening ... mitochondrial DNA-based ... Inc. (OTC,Bulletin Board: TBIO) today announced that it has ... the latest developments and,scientific opportunities in cancer detection screening ...
... ... Use, LA JOLLA, Calif., Jan. 17 Stemagen, a privately ... in the world to create, and meticulously document, a cloned human,embryo ... Wood, M.D., Ph.D., a co-author of the,publication and a donor of ...
... Trial will also Support a Marketing Authorization Application in the ... ... Agennix Incorporated announced today,that the U.S. Food and Drug Administration ... evaluating its lead molecule,talactoferrin alfa, in combination with chemotherapy as first-line,treatment ...
Cached Biology Technology:Transgenomic, Inc. Forms Scientific Advisory Board 2Transgenomic, Inc. Forms Scientific Advisory Board 3Stemagen First to Create Cloned Human Embryos From Adult Cells 2Stemagen First to Create Cloned Human Embryos From Adult Cells 3Agennix Receives Special Protocol Assessment Approval from FDA for the Pivotal Trial of Talactoferrin Alfa in First-Line Non-Small Cell Lung Cancer 2Agennix Receives Special Protocol Assessment Approval from FDA for the Pivotal Trial of Talactoferrin Alfa in First-Line Non-Small Cell Lung Cancer 3Agennix Receives Special Protocol Assessment Approval from FDA for the Pivotal Trial of Talactoferrin Alfa in First-Line Non-Small Cell Lung Cancer 4Agennix Receives Special Protocol Assessment Approval from FDA for the Pivotal Trial of Talactoferrin Alfa in First-Line Non-Small Cell Lung Cancer 5
... StdSens analysis kit for 25 chips provides ... standard-sensitivity RNA analysis (at nanogram levels) with ... includes 25 RNA StdSens microfluidic chips, 2 ... 20 microliters RNA StdSens stain, 2 x ...
... White solid. PROTECT FROM LIGHT. PACKAGED ... soluble pyrimidinone compound that acts as a ... PARP (IC 50 = 200 nM ... respectively) with little activity against the dehydrogenase ...
... on the ease of use and flexibility of the ... introduces the BDTM LSR II. The BD LSR ... in a benchtop analyzer. Free up your high-performance ... UV laser to the BD LSR II. The BD ...
... Engine Opticon 2 real-time PCR detection system ... fluorescence excitation (470-505 nm) and two photomultiplier ... nm). The Opticon 2 system is built ... includes a thermal gradient feature. This item ...
Biology Products: