Navigation Links
Sugar on bacteria surface serves as base for a web of resistance
Date:4/21/2009

COLUMBUS, Ohio The bacteria responsible for chronic infections in cystic fibrosis patients use one of the sugars on the germs' surface to start building a structure that helps the microbes resist efforts to kill them, new research shows.

Scientists have determined that the bacterial cell-surface sugar, a polysaccharide called Psl, is anchored on the surface of the bacterium as a helix, providing a structure that encourages cell-to-cell interaction. When multiple bacterial cells join together with the help of such a structure, they form what is called a biofilm, a persistent community of bugs that is able to resist the effects of a human immune response, as well as antibiotic drugs.

In the case of the bacterium being studied, Pseudomonas aeruginosa, the results of biofilm development can be lethal. Chronic infection with these bacteria is what causes the death of most patients with cystic fibrosis, a genetic disease characterized in part by excess mucus in the lungs a condition that can foster creation of the biofilm. Some critically ill hospitalized patients also are susceptible to infection by Pseudomonas, which can lead to sepsis or bacteremia, common causes of death in very sick intensive-care patients.

With Psl clearly identified as the foundation of the matrix, or the architectural glue that holds a biofilm together, scientists hope the research could lead to therapies that target the sugar and thus prevent the development of these masses of bacterial cells.

"From a clinical perspective, if we can figure out ways to inhibit or destroy Psl, we could free up these organisms and they'd be much more readily killed by antibiotics or by the host's defense," said Daniel Wozniak, professor of internal medicine and microbiology at Ohio State University and senior author of the study.

"Many antibiotics target actively growing cells, but biofilms go into a dormant mode of growth. This comes into play with resistance.
'/>"/>

Contact: Daniel Wozniak
daniel.wozniak@osumc.edu
614-247-7629
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Nutrition experts propose new class of low-sugar drinks to help stem obesity and diabetes epidemics
2. Spun-sugar fibers spawn sweet technique for nerve repair
3. High blood sugars impact on immune system holds clues to improving islet cell transplants
4. Engineering algae to make fuel instead of sugar
5. Genes determine whether sugar pills work
6. A spoonful of sugar?
7. Master gene plays key role in blood sugar levels
8. Acrylic glass made of sugar
9. Apelin hormone injections powerfully lower blood sugar
10. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
11. New process derives green gasoline from plant sugars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... kilometres of new roads will be built worldwide by ... last wildernesses, where they bring an influx of destructive ... ambitious study has created a ,global roadmap, for prioritising ... the competing demands of development and environmental protection. , ... estimates that natural importance of ecosystems and a ,road-benefits, ...
(Date:8/28/2014)... alert the world to Global Warming, has called for ... underground. He says that Carbon Capture, combined with limits ... avoid global warming getting out of control over the ... made the call during his presentation to the International ... meeting to discuss Carbon Capture and Storage. , ...
(Date:8/28/2014)... Biologists at Ludwig-Maximilians-Universitaet (LMU) in Munich have assigned ... genus of predatory arthropods. These animals lived in ... than related forms found in Jurassic strata. ... their shallow marine habitat and were fossilized some ... other denizens of the Silurian seas although ...
Breaking Biology News(10 mins):Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Paleontology: Oldest representative of a weird arthropod group 2
... lung cancer patients most likely to respond to the drug ... drug cetuximab (Erbitux), according to a new study published in ... National Cancer Institute. Both drugs target the same gene ... lung cancer (NSCLC) have mutant versions of the epidermal growth ...
... by manipulating energy regulation of cells, a collaborative study ... cells lacking a tumor-suppressing kinase called LKB1 can still ... This energy regulation is essential for keeping cells ... signal new advances for combating cancerous tumor growth, but ...
... Investigators report safety findings and statistically significant improvements ... 19th Annual Symposia on the Etiology, Pathogenesis and ... Phase I trial showed positive interim results in ... treatment, patients exhibited a statistically significant improvement in ...
Cached Biology News:Treatments have same target, different responses for lung cancer patients with genetic mutation 2Energy management in cells may hold key to cancer defense 2Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 2Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 3Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 4Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 5Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 6
(Date:8/28/2014)... 28, 2014 Sterlitech is proud to ... to its stable of products . These ... cut-offs and include membrane filters with surface charges. ... customer demand for our membrane process testing equipment, and ... flat sheet membranes,” explains Sterlitech President Mark Spatz. ...
(Date:8/28/2014)... Earlier this month, a report was ... the U.S. Air Force on the performance of vehicles ... this type of fuel made from mustard seeds, offered ... to America’s Eco friendly future. In fact, every branch ... become independent of foreign oil over the next few ...
(Date:8/27/2014)... 2014 Green & Grow Inc. (GGI) ... funding and secured Otter Capital as a significant new ... commercialization of GGI’s Agriplier™ technology, building on recent compelling ... “Since our first meeting, we have been impressed with ... space,” said Alan Sobba, President and CEO of GGI. ...
(Date:8/27/2014)... is how plants survive impact by the huge ... while using this energy for photosynthesis. The hypothesis ... blades quickly dissipate the energy throughout the entire ... DTU Physics have now managed to successfully ,film, ... contain light-absorbing proteins which play a role in ...
Breaking Biology Technology:Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3DTU researchers film protein quake for the first time 2
... Wis. - Lucigen Corp . and ... giving Lucigen exclusive worldwide rights to manufacture and sell ... , ,Under the agreement, Imaxio will retain the right ... applications, but Lucigen will provide the cells to commercial ...
... - It has yet to turn a profit, and it ... scope, but the decision by Madison research tool manufacturer NimbleGen ... to $75 million is the latest bit of evidence that the ... continues a pattern of growth and visibility for NimbleGen, which ...
... Alfalight , a manufacturer of high-power diode lasers, has ... million from the U.S. Army Research Laboratory . ... suitable for pumping high-power, fiber-laser systems, developed in conjunction ... commercial products. , ,Manoj Kanskar, vice president of research ...
Cached Biology Technology:Lucigen Corp. enters global licensing agreement 2IPO-bound NimbleGen traveling in fast company 2IPO-bound NimbleGen traveling in fast company 3IPO-bound NimbleGen traveling in fast company 4
ANTI S. GROUP AG:H...
This kit only detects beta-galactosidase activity at pH 6 in cultured cells andtissue sections. Beta-galactosidase activity at pH 6 ispresent only in senescent cells, and is not found inpresenescent...
2,4,6, Trinitrophenyl hapten is conjugated to lipopolysaccharide (LPS)....
... This service is for when you need to ... increase their transformation efficiency. Our services for preparing ... your applications. MCLab's custom competent cell service offers: ... ) Fast turnaround Quality ...
Biology Products: