Navigation Links
Sugar helping map new ground against deadly bug
Date:4/18/2011

A potential vaccine against bacteria that cause serious gastric disorders including stomach cancer may be a step closer following a pioneering study by a University of Guelph chemist.

In the first published study of its kind, a team led by Prof. Mario Monteiro, Department of Chemistry, found a carbohydrate-based antigen caused mice to develop antibodies against a common bacterium linked to gastric cancer.

"This is the first jab at a sugar-based vaccine against Helicobacter pylori," said Monteiro, who completed the study with former undergrad student Stacey Britton.

Their study was published recently in the journal Vaccine.

H. pylori is among numerous risk factors for stomach cancer. About half of the world's population has been infected by the bacterium during their lifetime. In Canada, the bug is especially prevalent in Aboriginal communities. It can cause gastritis and ulcers. Most infections are handled by antibiotics, but a vaccine would improve current treatment, said Monteiro.

Many scientists study potential vaccines based on proteins to prevent or control infection. Since arriving at Guelph in 2004, Monteiro has studied more complicated conjugates containing both proteins and sugars.

The Guelph researchers used a single bacterial strain in mice to induce an immune response against various strains of the bacteria.

He has studied sugar-based vaccines against two other gastric pathogens: Campylobacter jejuni, which causes travellers' diarrhea, and C. difficile, which causes antibiotic-associated diarrhea. He plans to begin studies of conjugates for use against tuberculosis.


'/>"/>

Contact: Mario Monteiro
monteiro@uoguelph.ca
519-824-4120 x53447
University of Guelph
Source:Eurekalert

Page: 1

Related biology news :

1. Sugarcane cools climate
2. Sugarcane bioethanol: Environmental implications
3. Missing sugar molecule raises diabetes risk in humans
4. Living in the matrix: Sugar residues regulate growth and survival of nerve cells
5. Coffee, energy drinkers beware: Many mega-sized drinks loaded with sugar, MU nutrition expert says
6. Shotgun method allows scientists to dissect cells sugar coatings
7. Researchers find link between sugar, diabetes and aggression
8. Scientists discover new mechanism for controlling blood sugar level
9. HIV drugs interfere with blood sugar, lead to insulin resistance
10. Sugar and slice make graphene real nice
11. Research shows sugary drinks do not cause weight gain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/24/2017)... MILAN , March 24, 2017 The Controller ... Deputy Controller Mr. Abdulla Algeen have received the prestigious international ... Continue Reading ... ... small picture) and Deputy Controller Abdulla Algeen (small picture on the right) ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... ... Clinical Supplies Management (“CSM”), a Great Point Partners II (“GPP”) portfolio company, today announced ... in size over the past six months with the acquisition of businesses in Belgium ... as Chief Financial Officer. Roger has over 25 years of experience in finance ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... stress expertise, and further enhances its scientific power by providing investigators access ... Ph.D., has agreed to join the scientific advisory board. “We are committed ...
(Date:5/18/2017)... ... May 17, 2017 , ... USDM Life ... for the life sciences and healthcare industries, is honored that Jay Crowley ... Devices conference in Brussels, Belgium. , Crowley played a crucial role in the ...
(Date:5/18/2017)... ... May 17, 2017 , ... G-CON Manufacturing, Inc., ... Executive Officer, Maik Jornitz, was recognized as a Top 10 Industry Influencer on ... individuals “involved in bettering the pharma industry and bringing life-changing medicines to market” ...
Breaking Biology Technology: