Navigation Links
Sugar-burning in the adult human brain is associated with continued growth, and remodeling
Date:1/7/2014

eased during childhood and accounts for as much as one third of total brain glucose consumption at its peak around 5 years of age, which is also the peak of synapse development.

Since aerobic glycolysis varies by region of the brain, Hawrylycz and co-author Marcus Raichle, Ph.D., at Washington University in St. Louis, wondered whether regions of the brain with higher levels of aerobic glycolysis might be associated with equivalent growth processes, like synapse formation. If so, this would point to aerobic glycolysis as a reflection of "neoteny," or persistent brain development like the kind that takes place during early childhood.

In order to delve into the significance of aerobic glycolysis, researchers examined the genes expressed at high levels in those regions where aerobic glycolysis was taking place. The team identified 16 regions of the brain with elevated levels of aerobic glycolysis and ranked their neotenous characteristics. True to prediction, they found that gene expression data from those 16 regions suggested highly neotenous behavior.

The next phase was to identify which genes were specifically correlated with aerobic glycolysis in those regions. The Allen Brain Atlas resources proved crucial in this task, helping to pinpoint gene expression in different regions at various points in development. The Allen Human Brain Atlas was used to investigate the adult human brain, while the BrainSpan Atlas of the Developing Human Brain, developed by a consortium of partners and funded by the National Institutes of Health, provided a window into how gene expression changes as the brain ages.

Analysis of the roles of those genes pointed clearly towards their roles in growth and development; top genes included those responsible for axon guidance, potassium ion channel development, synaptic transmission and plasticity, and many more. The consistent theme was development, pointing to aerobic glycolysis as a hallmark for neotenou
'/>"/>

Contact: Steven Cooper
Steven.Cooper@edelman.com
646-358-2765
Edelman Public Relations
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Large international study finds memory in adults impacted by versions of 4 genes
2. The weight of nations: An estimation of adult human biomass
3. New review outlines screening strategies for osteoporosis in young adults
4. Omega-3 lowers inflammation in overweight older adults
5. Notre Dame establishes professorships in adult stem cell research
6. Study results: Adult stem cells from bone marrow
7. Lower vitamin D could increase risk of dying, especially for frail, older adults
8. UIC study examines exercise and weight loss for older adults with osteoarthritis
9. Long menopause allows killer whales to care for adult sons
10. Nutrient in eggs and meat may influence gene expression from infancy to adulthood
11. Omega-3 intake heightens working memory in healthy young adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Millions of people in the United States have a ... It can be painful and may even require surgery ... skeletal muscle wasting and, in turn, limb amputation. , ... Houston (UTHealth) Medical School, scientists tested a non-surgical preventative ... it was associated with increased blood circulation. Their ...
(Date:7/28/2014)... pinpointed a mechanism in part of the brain that is ... to both type 1 and type 2 diabetes. The findings ... of the National Academies of Sciences . , "We,ve ... part of the hypothalamus known as the ventromedial nucleus ... levels in the blood," said lead author Sabrina Diano, professor ...
(Date:7/28/2014)... top 10 U.S. cities that have seen an increase ... frequent road closures, overwhelmed storm drains and compromised infrastructure--are ... technical report. , This nuisance flooding, caused by rising ... between 300 and 925 percent since the 1960s. , ... Changes around the United States, also finds Annapolis and ...
Breaking Biology News(10 mins):Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Glucose 'control switch' in the brain key to both types of diabetes 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3
... by a scientist from The University of Western Ontario ... accepted as fact. Since renowned British biologist ... the ,selfish gene, in 1976, scientists the world over ... the work of Charles Darwin. In studying ...
... may provide the key to better traffic management and ... That is the hope of a new research collaboration ... Indian Institute of Technology Delhi (IIT- New Delhi), IPICO ... million initiative is receiving $1.2 million in matching funding ...
... mechanisms that underlie long-term memory research with the potential ... more we know about how long-term memory is induced in ... brain, the more we are going to be able to ... physiological science and neurobiology, whose new research appears June 19 ...
Cached Biology News:Canada-India RFID project looks to improve traffic flow, reduce pollution 2Study of marine snail leads to new insights into long-term memory 2Study of marine snail leads to new insights into long-term memory 3Study of marine snail leads to new insights into long-term memory 4
(Date:7/29/2014)... July 29, 2014 Philadelphia’s newest entrepreneurial incubation ... get their start. The Innovation Center @3401 , a ... University City Science Center to help attract and nurture ... Monday, July 28. , The Innovation Center ... and Market Streets, is the new home of DreamIt ...
(Date:7/29/2014)... , July 29, 2014  Sigma-Aldrich Corporation (NASDAQ: ... and energy use, increased its investment in Green Chemistry ... around the world last year, the Company announced Monday ... if Science Changed the World? The ... several honors for being a responsible corporate citizen, including ...
(Date:7/29/2014)... Quorum Review IRB, the industry leader ... by the International Association of Six Sigma ... Deployment Program. The citation recognizes robust organizational enhancements ... Lean Six Sigma program was evaluated by IASSC ... designation is a public statement of excellence and ...
(Date:7/29/2014)... 2014 G-CON Manufacturing Inc., the standard ... announced a new leadership appointment designed to drive the ... abroad. , Maik Jornitz, Chief Operating Officer of ... charged with leading the pioneering company through its next ... stage of development and look forward to providing our ...
Breaking Biology Technology:Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2
... UC Riverside Bourns College of Engineering have built and successfully ... more efficient circuits in electronic chips, such as those used ... Graphene, a single-atom thick carbon crystal, was first isolated in ... Nobel Prize in physics this month for that work. Graphene ...
... Reportlinker.com announces that a new market research ... Global Automated And Rapid Microbiological ... This report analyzes the ... Tests in US$ Million by the following ...
... (NYSE: BMR ) today announced it will report ... the market closes on Wednesday, November 3, 2010. ... Griffin, President, and Greg N. Lubushkin, Chief Financial Officer, will ... on Thursday, November 4, 2010 to discuss the company,s financial ...
Cached Biology Technology:Lastest graphene research could lead to improvements in bluetooth headsets and other devices 2Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 2Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 3Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 4Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 5Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 6Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 7Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 8Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 9Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 10Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 11Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 12Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 13Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 14Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 15Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 16Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 17Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 18Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 19Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 20Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 21Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 22Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 23Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 24Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 25BioMed Realty Trust to Report 2010 Third Quarter Results 2
UBC13 Antibody...
HLA II DG+DR+DP Monoclonal Antibody, Purified, Unconjugated, Clone: IQU9 This antibody is specific for the monomorphic determinant of the HLA Class II beta chains of the human MHC (28 kDa)....
Phenytoin-BSA Isolated IgY DFc Drug...
Tropomyosin 4 [Tm4]...
Biology Products: