Navigation Links
Successful stem cell therapy for treatment of eye disease
Date:12/10/2009

Newcastle, United Kingdom, December, 2009 Newly published research, by investigators, at the North East England Stem Cell Institute (NESCI) in the journal Stem Cells reported the first successful treatment of eight patients with "Limbal Stem Cell Deficiency" (LSCD) using the patients' own stem cells without the need of suppressing their immunity.

LSCD is a painful, blinding disease that requires long-term, costly treatment with frequent clinic visits and intensive hospital admissions. The vision loss due to LSCD makes this disease not only costly, but often requires social support due to the enormous impact on patient's quality of life. This is further magnified by the fact that LSCD mostly affects young patients.

Dr Francisco Figueiredo, a member of the NESCI team, said, "Corneal cloudiness has been estimated to cause blindness in 8 million people (10% of total blindness) worldwide each year. A large number of ocular surface diseases, both acquired and congenital, share features of partial or complete LSCD. "

Chemical burns to the eye are the most common cause of LSCD.

Professor Lako said: "This study demonstrates that transplantation of cultured corneal stem cells without the use of animal cells or products is a safe and effective method of reconstructing the corneal surface and restoring useful sight in patients with unilateral LSCD.

"This research shows promise to help hundreds of people regain their sight. These exciting results offer a new treatment and hope for people with LSCD."

Professor Michael Whitaker FMedSci, Co-Director of NESCI, which is a collaboration between Durham and Newcastle Universities, Newcastle NHS Foundation Trust and other partners, said: "Stem cells from bone marrow have been used successfully for many years to treat cancer and immune disease, but this is the first successful stem cell therapy using stem cells from the eye without animal products to treat disease, an important step towards the clinic. Because the early results look so promising, we are thinking hard now about how to bring this treatment rapidly into the clinic as we complete the necessary clinical trials, so that the treatment can be shared with all patients that might benefit."

"The Newcastle team has obtained some very impressive results in patients following stem cell transplants to repair the surface of the cornea. It is hugely exciting to see that a type of stem cell therapy can now be applied routinely to treat a form of blindness," said Professor Robin Ali, FMedSci, Department of Genetics, UCL Institute of Ophthalmology, London. "These results also provide us with further encouragement to develop stem cell therapies to repair the retina in order to treat conditions such as age related macular degeneration."

A larger study involving 24 new patients is currently underway with funding from the UK's Medical Research Council.


'/>"/>

Contact: Ben Norman
Benorman@wiley.com
44-124-377-0375
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. Pathological gambling may be successfully treated with medications for substance addiction
2. MSU researcher: Obesity significantly cuts odds of successful pregnancy
3. Rare genetic disease successfully reversed using stem cell transplantation
4. InVitria Successfully Completes Beta Testing and Announces Commercial Launch of Optiferrin for Mammalian Cell Culture
5. UOG scientists successfully compete for research grants
6. McGill/JGH researchers successfully reverse multiple sclerosis in animals
7. Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action
8. In troubled economic times, BioSquare 2009 successfully serves as business and innovation starter
9. Salk researchers successfully reprogram keratinocytes attached to a single hair
10. Gap junction protein vital to successful pregnancy, researchers find
11. Successful series of measurements in Arctic sea ice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... and WARSAW, Poland , Nov. 30, 2016 Not ... one of the most crucial aspects of recovery so we need to do it ... health risks, including heart problems, high blood pressure, stroke, diabetes, and even cancer. ... sleep and find a Christmas present that could help them to manage their sleep ... ...
(Date:11/29/2016)... BioDirection, a privately held medical device company developing novel ... concussion and other traumatic brain injury (TBI), announced today ... the U.S. Food and Drug Administration (FDA) to review ... meeting company representatives reviewed plans for clinical development of ... a planned pilot trial. "We are ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 01, 2016 , ... Aerocom Healthcare ( http://www.aerocomhealthcare.com ... will present its chain-of-custody solution for tracking and securing medications at booth 676 ... 4-8, 2016. , Aerocom has a proven solution for tracking medications via its ...
(Date:12/2/2016)... NY (PRWEB) , ... December 01, 2016 , ... The ... is expanding to three days and will take place on February 1-3, 2017 at ... and Dr James Gulley (NCI), the program provides a unique 360-degree approach, which addresses ...
(Date:12/2/2016)... (PRWEB) , ... December 01, 2016 , ... ... congratulate long-term client Nanowear on their recent FDA Class II 510(k) clearance for ... a significant hurdle in commercializing remote cardiac monitoring devices that rely on cloth-based ...
(Date:12/2/2016)... ... December 02, 2016 , ... Robots will storm the Prudential ... December 3rd, 2016. The event, which is held on the United Nations International Day ... with Disabilities back into the workplace. Suitable Technologies is partnering with NTI to showcase ...
Breaking Biology Technology: