Navigation Links
Success of engineered tissue depends on where it's grown
Date:8/14/2012

CAMBRIDGE, Mass. -- Tissue implants made of cells grown on a sponge-like scaffold have been shown in clinical trials to help heal arteries scarred by atherosclerosis and other vascular diseases. However, it has been unclear why some implants work better than others.

MIT researchers led by Elazer Edelman, the Thomas D. and Virginia W. Cabot Professor of Health Sciences and Technology, have now shown that implanted cells' therapeutic properties depend on their shape, which is determined by the type of scaffold on which they are grown. The work could allow scientists to develop even more effective implants and also target many other diseases, including cancer.

"The goal is to design a material that can engineer the cells to release whatever we think is most appropriate to fight a specific disease. Then we can implant the cells and use them as an incubator," says Laura Indolfi, a postdoc in Edelman's lab and lead author of a paper on the research recently published online in the journal Biomaterials.

Aaron Baker, a former postdoc in Edelman's lab and now an assistant professor at the University of Texas at Austin, is also an author of the paper.

Shape matters

For the past 20 years, Edelman has been working on using endothelial cells grown on scaffolds made of collagen as implantable devices to treat blood vessel damage. Endothelial cells line the blood vessels and regulate important process such as tissue repair and inflammation by releasing molecules such as chemokines, small proteins that carry messages between cells.

Several of the devices have been tested in clinical trials to treat blood vessel damage; in the new Biomaterials study, Edelman and Indolfi set out to determine what makes one such tissue scaffold more effective than another. In particular, they were interested in comparing endothelial cells grown on flat surfaces and those grown on more porous, three-dimensional scaffolds. The cell
'/>"/>

Contact: Caroline McCall
cmccall5@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Drivers of marine biodiversity: Tiny, freeloading clams find the key to evolutionary success
2. 3-D tumor models improve drug discovery success rate
3. Think pink! Success of pink bacteria in oceans of the world
4. The old primates club: Even male monkeys ride their fathers coattails to success
5. First paternity study of southern right whales finds local fathers most successful
6. Successful stem cell differentiation requires DNA compaction, study finds
7. Different recipes for success in the world of plants
8. Lab-engineered kidney project reaches early milestone
9. Engineered robot interacts with live fish
10. Engineered microvessels provide a 3-D test bed for human diseases
11. New research reveals challenges in genetically engineered crop regulatory process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Saudi Arabia Biomedical Sensors Market - Growth, Trends & ... The Saudi Arabia Biomedical Sensors market is estimated ... 3.64% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
(Date:8/24/2015)... 2015  Based on its recent analysis of the biometric ... African Biometrics Company of the Year Award. DERMALOG is the ... in Africa . It has particularly gained ... implemented one of the largest biometric mass applications in the ... Central Bank of Nigeria with its ...
(Date:8/18/2015)... N.J. , Aug. 18, 2015 /PRNewswire/ ... a key contributor to the Submission Content ... by IRISS, a non-profit forum. Dedicated to the ... provides a neutral platform for industry, vendors, ... share information and work towards a standard ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3
... 2009) An indigenous family living in a ... (VARI) researchers to discover information about genetic mutations associated with ... hands, feet, and facial features. The information ... often results from a benign pituitary gland tumor that can ...
... between the two rows of six tall metal racks, opened ... processor cores that power Cystorm, Iowa State University,s second supercomputer. ... racks. Cystorm, a Sun Microsystems machine, boasts a peak ... the peak of CyBlue, an IBM Blue Gene/L supercomputer that,s ...
... indicates that a minor reduction in levels of one ... two divergent microbes: the virus that causes Ebola hemorrhagic ... the results suggest a common host restriction factor and ... completely different infections. Writing in the August 20 ...
Cached Biology News:Clues to gigantism provided by family in Borneo Mountains 2New Iowa State supercomputer, Cystorm, unleashes 28.16 trillion calculations per second 2New Iowa State supercomputer, Cystorm, unleashes 28.16 trillion calculations per second 3Single host gene may hold key to treating both ebola and anthrax infections 2Single host gene may hold key to treating both ebola and anthrax infections 3
(Date:9/2/2015)... ... September 02, 2015 , ... The TS5-Q ... professional commercial video content, to analysis of athletic performance. Producing high-resolution slow-motion ... by too quickly to process with the naked eye. , Slow motion ...
(Date:9/1/2015)... ... September 02, 2015 , ... Spirax Sarco , the leader in products ... Spirax Sarco Anytime. This platform, offering unique online ordering capabilities, is only available ... Log on to Spirax Sarco Anytime and within minutes you can be making ...
(Date:9/1/2015)... , Sept. 1, 2015 Prostate ... death in American men. One in seven ... 233,000 new cases are diagnosed annually. That said, ... using a powerful new technique, MRI Fusion Biopsy, ... large cancer lesions, treating only the affected areas ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... announced today that the National Institutes of Health (NIH) has awarded the company ... administered by the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases. ...
Breaking Biology Technology:Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3Spirax Sarco Announces New Features to Anytime Platform 2September Is Prostate Cancer Awareness Month 2September Is Prostate Cancer Awareness Month 3September Is Prostate Cancer Awareness Month 4AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 3
... Midwest health care startups reported $315 million in total ... 2011, according to the BioEnterprise Midwest ... ) "While the number of companies funded ... dollars invested is down compared to recent years," said ...
... advantage of the unique properties of zinc oxide ... piezoelectric resistive switching device in which the write-read ... modulation. Operating on flexible substrates, arrays of ... interface the mechanical actions of the biological world ...
... The Raymond and Ruth Perelman School of ... the launching of a first-of-its-kind interdisciplinary center focused ... Center will bring together, without institutional walls, all ... establishing dedicated research support facilities, translating findings into ...
Cached Biology Technology:Midwest Health Care Startups Raise $315 Million in First Half of 2011 2Midwest Health Care Startups Raise $315 Million in First Half of 2011 3Midwest Health Care Startups Raise $315 Million in First Half of 2011 4Piezoelectric nanowires allow electrical signals to be produced from mechanical actions 2Piezoelectric nanowires allow electrical signals to be produced from mechanical actions 3Piezoelectric nanowires allow electrical signals to be produced from mechanical actions 4Penn Receives $10 Million to Create Center for Orphan Disease Research and Therapy 2
Request Info...
... TURBO DNase (patent pending) was developed using ... changes into the DNA binding pocket of wild-type ... of the protein for DNA. The result is ... Km for DNA, and an ability to maintain ...
Request Info...
Request Info...
Biology Products: