Navigation Links
Substance found in fruits and vegetables reduces likelihood of the flu
Date:9/3/2008

BETHESDA, Md. (Sept. 3, 2008) Mice given quercetin, a naturally occurring substance found in fruits and vegetables, were less likely to contract the flu, according to a study published by The American Physiological Society. The study also found that stressful exercise increased the susceptibility of mice to the flu, but quercetin canceled out that negative effect.

Quercetin, a close chemical relative of resveratrol, is present in a variety of fruits and vegetables, including red onions, grapes, blueberries, tea, broccoli and red wine. It has been shown to have anti-viral properties in cell culture experiments and some animal studies, but none of these studies has looked specifically at the flu.

The study, "Quercetin reduces susceptibility to influenza infection following stressful exercise," was carried out by J. Mark Davis, E.A. Murphy, J.L. McClellan, and M.D. Carmichael, of the University of South Carolina and J.D. Gangemi of Clemson University. The study appears in the current issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

The study was conducted using mice, but if quercetin provides a similar benefit for humans, it could help endurance athletes, soldiers and others undergoing difficult training regimens, as well as people under psychological stress, according to Davis.

Study builds on previous research

"Quercetin was used because of its documented widespread health benefits, which include antiviral activity, abundance in the diet and reported lack of side effects when used as a dietary supplement or food additive," Davis said.

Earlier mouse studies have found that stressful exercise can increase susceptibility to upper respiratory infections, although it is not yet clear if the same is true for humans. There was also preliminary information that mice may be more susceptible to the flu when they exercise to fatigue. The researchers in the current study hypothesized that exercise would increase the chance of the mice getting the flu but that quercetin would counteract the increased risk.

Davis and his colleagues examined four groups of mice. Two groups performed three consecutive days of running to fatigue on a treadmill to mimic a short period of stressful exercise. One group of runners received quercetin, the other did not.

The remaining two groups did not exercise. One non-exercise group received quercetin while the other did not. All four groups were then exposed to a common flu virus, H1N1.

The researchers found that:

  • Stressful exercise increased susceptibility to the flu. The mice that exercised to fatigue for three days were more likely to develop the flu than the mice that did not exercise (91% versus 63%).
  • The mice that exercised developed the flu much sooner than those that did not (6.9 days versus 12.4 days).
  • Mice that exercised and took quercetin had nearly the same rate of illness as those that did not exercise. In other words, quercetin canceled out the negative effect of stressful exercise.
  • The severity of the symptoms among those mice that either did not exercise or those that exercised but took the quercetin was about the same.
  • Quercetin had protective effects for the mice that did not exercise.

Although this study was done with mice, a recent human study found that people who took quercetin suffered fewer illnesses following three days of exhaustive exercise compared to those who did not. Unlike the mouse study, the humans were not inoculated with a virus.

"This is the first controlled experimental study to show a benefit of short-term quercetin feedings on susceptibility to respiratory infection following exercise stress," said Davis. "Quercetin feeding was an effective preventive strategy to offset the increase in susceptibility to infection that was associated with stressful exercise."


'/>"/>

Contact: Christine Guilfoy
301-634-7253
American Physiological Society
Source:Eurekalert

Related biology news :

1. New method reveals substances on surfaces of any kind
2. Motor neuron disease and toxic substances: Possible link?
3. Researchers develop new ultrasensitive assay to detect most poisonous substance known
4. Substance in red wine found to keep hearts young
5. Tests show LLNL detection instrument can monitor the air for all major terrorist threat substances
6. Argyrin: Natural substance raises hope for new cancer therapies
7. Key to out-of-control immune response in lung injury found
8. Natural chemical found in broccoli helps combat skin blistering disease
9. Balzan Foundation announces 2007 winners
10. Keck Foundation funds study of biological interactions with nanomaterials
11. Yu receives research funding from the Wallace H. Coulter Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2, 2016  BioMEMS devices deployed in ... on medical screening and diagnostic applications, such ... devices that facilitate and assure continuous monitoring ... are being bolstered through new opportunities offered ... acquisition coupled with wireless connectivity and low ...
(Date:2/2/2016)... , Feb. 2, 2016   Parabon ... from the U.S. Army Research Office and the ... range and sensitivity of the company,s Snapshot ... Accounting Mission and, more generally, defense-related DNA forensics. ... phenotyping capabilities (predicting appearance and ancestry from DNA ...
(Date:2/1/2016)... Fla. , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ... and television personality, Joey Fatone . Las Vegas ... greet fans. --> Las Vegas , where ... --> The new video ad was filmed at the Consumer ... appeared at the Wocket booth to meet and greet fans. ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... 09, 2016 , ... With a presidential election in November and the future ... bring together over 500 top healthcare leaders for a night and day of debates ... by MBA students of the University of Pennsylvania’s Wharton School, will be held February ...
(Date:2/9/2016)... ... 2016 , ... Tunnell Consulting, Inc. announced that Frédéric Lefebvre has joined the ... acquiring new accounts and work closely with existing Tunnell clients throughout Europe to ensure ... European clients more than 15 years of experience in the pharmaceutical industry, a thorough ...
(Date:2/9/2016)... NEW YORK , Feb. 9, 2016 ... market analyzes the current and future prospects of the ... of this report include companies engaged in the manufacture ... comprises an executive summary with a market snapshot providing ... the scope of this report. This section also provides ...
(Date:2/8/2016)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... technology companies in the TSX Venture 50 TM . ... the TSX Venture Exchange, in each of five major industry ... & life sciences, diversified industries and technology – based on ... investment, market cap growth, trading volume and analyst coverage. All ...
Breaking Biology Technology: