Navigation Links
Studying the metabolome of smokers, Lombardi researchers find early signs of damage
Date:11/7/2010

king-related toxins differently, the study enrolled 5 light smokers (fewer than 12 cigarettes a day) and 5 heavy smokers (23 or more cigarettes smoked a day).

The researchers then analyzed the global metabolomic profile of about 3,000 chemicals in the blood of each smoker. A metabolite is produced when anything taken into the body such as food, tobacco smoke, alcohol, medicine is metabolized, or broken down into chemicals that produce a biological function via metabolic pathways. The global metabolome is the network of metabolic reactions, and metabolomics is analysis of the metabolome at any given time.

Using complicated tools, researchers can trace the metabolites in the context of relevant pathways that are affected by cigarette smoke including cell death, cell-cell interactions (a marker of inflammation), lipid metabolism, and gene expression In heavy smokers, they then traced metabolites that were being produced after smoking back to damage in multiple organs and to a breakdown in the phospholipids that make up a cell's membrane, and a change in production of bile acids.

The study is ongoing, and researchers also plan to compare changes in those smokers' metabolome to their transcriptome all RNA molecules produced in the cells of the smokers, which was done in the lab few years ago. This would reflect the genes that are actively being expressed at a given time.

"One goal of our work is to identify new risk markers for lung cancer that can then enhance early detection of smoking-related disorders, and to do that we need to develop new biomarkers," Hsu says.


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
2. Carnegie Mellon receives funding to create new program studying environmental impact of nanotechnology
3. New retrieval method makes studying cancer proteins easier
4. Introducing Robofish: Leading the crowd in studying group dynamics
5. Studying cells in 3-D could reveal new cancer targets
6. New lab manual for studying the biology of the nervous system in Drosophila is released
7. Studying hair of ancient Peruvians answers questions about stress
8. Exploration by explosion: Studying the inner realm of living cells
9. Model microbial community for studying expanding dead zones characterized
10. Geologists studying groundwater arsenic levels in India empower Bengali women, children
11. K-State receives more than $780,000 to fund graduate students studying ecology, evolution, genomics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... August 22, 2014 ... has announced the addition of the  ...  report to their offering.  ... is a technology that helps in ... their physical or behavioral features. It ...
(Date:8/22/2014)... RIVERSIDE, Calif. Thomson Reuters , a leading ... five researchers at the University of California, Riverside in ... brightest minds of our times." , To generate the ... (2002-2012) to identify researchers whose published work has had ... included among some 3,200 individuals who published the greatest ...
(Date:8/22/2014)... Research presented at the 29th Annual International ... by Hera Therapeutics Inc. combats three types of ... percent of all cervical cancer. , When tested ... the replication of HPV-16, HPV-18 and HPV-11 cells, ... Broker, Ph.D., who presented the findings at the ...
Breaking Biology News(10 mins):Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 2Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 35 UC Riverside scientists among world's most influential scientific minds 2
... Pfizer Inc., a major biopharmaceutical company, and the Wisconsin ... licensing organization for the University of Wisconsin-Madison, announced May ... embryonic stem (hES) cell patents for the development of ... the rights to work with hES cells for drug ...
... University of Houston to use technologies with origins in ... help doctors and technicians better plan radiation therapy for ... Kamrani, founding director of the Design and Free Form ... researcher, is teaming up with Dr. Lei Dong, associate ...
... National Center for Research Resources (NCRR), part of ... will provide up to an estimated $122 million ... Development Award (IDeA) Networks of Biomedical Research Excellence ... development, coordination and sharing of research resources and ...
Cached Biology News:WARF signs license agreement with Pfizer for human embryonic stem cells 2From cars to cancer: UH professor employs auto industry tools for tumor therapy 2From cars to cancer: UH professor employs auto industry tools for tumor therapy 3From cars to cancer: UH professor employs auto industry tools for tumor therapy 4NIH grants $122 million in Institutional Development Awards 2NIH grants $122 million in Institutional Development Awards 3
(Date:8/21/2014)... Aug. 21, 2014 OTC Markets ... Inc., a biotechnology company, on its approval to ... traded on OTCQX®, the best marketplace for established ... Group. Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... successful execution of its growth strategy and achievement ...
(Date:8/21/2014)... Chester, NJ (PRWEB) August 21, 2014 ... of personal selling optimization technology and services for ... publication of “Grading Pharma’s Use of New Commercial ... of Measurement & Analytics. , The article examines ... marketing yield that are being tested in the ...
(Date:8/21/2014)... SoundConnect , a unified ... one of the nation’s Fastest Growing Private Companies ... 2nd consecutive year. Inc. magazine today ranked SoundConnect ... an exclusive ranking of the nation's fastest-growing private ... at the most important segment of the economy—America’s ...
(Date:8/20/2014)... university inventions licensed to biotechnology firms has revealed ... open these roadblocks, the researchers suggest that better ... stage could lead to faster commercialization down the ... discoveries made in university laboratories and licensed to ... trials, which have a high failure rate. But ...
Breaking Biology Technology:OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3
... Madison, Wis . - Bruker AXS , a supplier ... of Bruker BioSciences , announced on Tuesday the introduction ... lines. , ,The new systems were unveiled at the ... ,Axiom 200, a new digital imaging detector for macromolecular X-ray ...
... The life sciences provider Promega broke ground on Wednesday for ... Center, located next to the existing Promega offices. , ,The ... near Cheryl Parkway and Fish Hatchery Road, 62,000 of which ... be retail space. The expansion will provide Promega with further ...
... will invest more than $300 million this year on ... on-air 110 new cell sites, the company announced on ... to enhance and expand its Allover network nationwide over ... put into service 22 cell sites improving coverage in ...
Cached Biology Technology:
... the only microplate sealer with an integrated ... times with a variety of configurations and ... with integrated stacker and 240-plate storage capacity ... use in small workcells , Handles all ...
... LC Sciences provides a comprehensive service ... high density peptide microarrays synthesized on ... using recombinant proteins/antibodies or serum samples. ... your sequence designs, binding assays using ...
... ,Schistosomal glutathione-S-transferase (GST) is commonly ... proteins in E. coli (1). The GSTTag ... production and in some cases the solubility ... a soluble, properly folded form, GSTTag fusion ...
... with BioTeks microplate washers, dispensers and ... and walkaway automation are guaranteed for ... with the ELx405 washer or Fill ... footprint fits easily in most standard ...
Biology Products: