Navigation Links
Studying the metabolome of smokers, Lombardi researchers find early signs of damage
Date:11/7/2010

Philadelphia, Pa. Examining the blood "metabolomics" profile of smokers immediately after they had a cigarette revealed activation of pathways involved in cell death, inflammation, and other forms of systemic damage, say researchers at Georgetown Lombardi Comprehensive Cancer Center, part of Georgetown University Medical Center.

They say their findings, presented at the Ninth AACR Frontiers in Cancer Prevention Research Meeting, is the best analysis for chemicals unequivocally produced by smoking and indicates the potential toll that carcinogens and toxins poise to smokers years before lung cancer, heart disease, or other smokingrelated diseases appear.

"Our analysis uncovered hallmarks of liver, heart, and kidney toxicity in otherwise healthy patients," says the study's lead investigator, Ping-Ching Hsu, a doctoral student who works in the laboratory of oncology researcher Peter Shields, MD, who specializes in tobacco carcinogenesis. Shields is the senior author.

Shields says the findings could help in the development of new blood tests that will allow researchers to assess the harmfulness of one tobacco product compared to another. This could be useful to the federal Food and Drug Administration, the agency charged by Congress to begin controlling the contents of cigarettes.

The study presents a new way to evaluate the effect of cigarette smoking in humans, say the researchers. Previously, cigarette manufacturers were only required to use machines that "smoked" cigarettes to derive the chemical content of potential carcinogens. "We have come up with an actual picture of what is happening in the body of smokers and the harm that is being produced," Hsu says.

In their pilot study, they analyzed the blood of 10 smokers before and after they smoked a cigarette, and then measured the effects again after a second cigarette smoked one hour later in a smoking laboratory. Because frequent tobacco users may metabolize smoking-related toxins differently, the study enrolled 5 light smokers (fewer than 12 cigarettes a day) and 5 heavy smokers (23 or more cigarettes smoked a day).

The researchers then analyzed the global metabolomic profile of about 3,000 chemicals in the blood of each smoker. A metabolite is produced when anything taken into the body such as food, tobacco smoke, alcohol, medicine is metabolized, or broken down into chemicals that produce a biological function via metabolic pathways. The global metabolome is the network of metabolic reactions, and metabolomics is analysis of the metabolome at any given time.

Using complicated tools, researchers can trace the metabolites in the context of relevant pathways that are affected by cigarette smoke including cell death, cell-cell interactions (a marker of inflammation), lipid metabolism, and gene expression In heavy smokers, they then traced metabolites that were being produced after smoking back to damage in multiple organs and to a breakdown in the phospholipids that make up a cell's membrane, and a change in production of bile acids.

The study is ongoing, and researchers also plan to compare changes in those smokers' metabolome to their transcriptome all RNA molecules produced in the cells of the smokers, which was done in the lab few years ago. This would reflect the genes that are actively being expressed at a given time.

"One goal of our work is to identify new risk markers for lung cancer that can then enhance early detection of smoking-related disorders, and to do that we need to develop new biomarkers," Hsu says.


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Related biology news :

1. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
2. Carnegie Mellon receives funding to create new program studying environmental impact of nanotechnology
3. New retrieval method makes studying cancer proteins easier
4. Introducing Robofish: Leading the crowd in studying group dynamics
5. Studying cells in 3-D could reveal new cancer targets
6. New lab manual for studying the biology of the nervous system in Drosophila is released
7. Studying hair of ancient Peruvians answers questions about stress
8. Exploration by explosion: Studying the inner realm of living cells
9. Model microbial community for studying expanding dead zones characterized
10. Geologists studying groundwater arsenic levels in India empower Bengali women, children
11. K-State receives more than $780,000 to fund graduate students studying ecology, evolution, genomics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2017)... CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made in ... ... combined in one project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification ... Used combined in one project, multi-biometric solutions provide a ... ...
(Date:3/7/2017)... March 7, 2017 Brandwatch , the leading social ... The Prince,s Trust to uncover insights to support its reporting, ... The UK,s leading youth charity will be using Brandwatch ... and get a better understanding of the topics and issues that ... ...
(Date:3/2/2017)... , March 2, 2017 Summary ... to better understand Merck KGaA and its partnering interests ... https://www.reportbuyer.com/product/3605601/ Description The Partnering Deals and ... the partnering activity of one of the world,s leading ... are prepared upon purchase to ensure inclusion of the ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... , March 23, 2017  Northwest Biotherapeutics (OTCQB: ... personalized immune therapies for solid tumor cancers, today ... million financing it announced last Friday, March 17, ... several institutional investors securities totaling 28,843,692 shares, comprised ... and 10,000,000 shares of Class C Warrants pre-funded ...
(Date:3/23/2017)... 2017  BioPharmX Corporation (NYSE MKT: BPMX), a ... market, today reported financial results for the quarter ... provide an update on the company,s clinical development ... "We are pleased to report that last year ... President Anja Krammer. "We achieved key clinical milestones ...
(Date:3/23/2017)... March 23, 2017 NetworkNewsWire Editorial Coverage  ... Cancer ... significant strain on health care systems, in terms of costs ... so too does the development of innovative and efficient therapies ... Among the many types of cancer treatments, a growing number ...
(Date:3/23/2017)... 2017 In today,s pre-market research, ... the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate ... SYN), and Regulus Therapeutics Inc. (NASDAQ: RGLS ... Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn ... at: ...
Breaking Biology Technology: