Navigation Links
Studying illnesses caused by worms: Scientists are learning how immune cells communicate
Date:10/8/2010

Saranac Lake, N.Y. A billion people living in underdeveloped areas around the world are infected with parasitic helminthes, worms that survive by residing in and feeding on their hosts. These infestations can cause chronic intestinal (and occasionally systemic) illnesses leading to long-term disability. Irah King and Markus Mohrs, biomedical researchers at the Trudeau Institute, are investigating illnesses caused by these gut-dwelling worms in an effort to decipher how immune cells send and receive signals that determine the specific immune response to mount.

In a study reported in the current issue of the Journal of Immunology, Dr. King and his colleagues demonstrate that a soluble factor released by CD4+ T cells (a subset of cells that aid B cells in generating an immune response) called interleukin-21 (IL-21) instructs B cells to produce antibodies that bind helminth-derived products and inhibit their ability to mature into adult worms in the host.

Using genetically modified mice that lack the receptor for IL-21, they found that B cells directly require IL-21 signals in order to differentiate into plasma cells, the major antibody-producing B cell subset. The role of IL-21 signaling in this context seems to be specific because it does not impact other forms of B cell activation or CD4+ T cell differentiation, another leukocyte subset critical for protective immunity to helminthes.

"It is already established that B cells must produce antibodies to protect us from gut-dwelling worms and other parasitic infections," said Dr. King. "However, the signals that B cells need to receive in order to produce antibodies following infection are not yet completely understood."

Scientists who study anti-parasite immunity understand that immune responses generated by worm infections are in many ways similar to responses generated by diseases more common in the developed world like asthma, allergies, and ulcerative colitis. By identifying these similarities, Dr. King and other researchers hope to point to new treatments and therapies for a host of diseases associated with problems in immune system regulation.


'/>"/>

Contact: Brian Turner
bturner@trudeauinstitute.org
518-891-3080
Trudeau Institute
Source:Eurekalert

Related biology news :

1. Carnegie Mellon receives funding to create new program studying environmental impact of nanotechnology
2. New retrieval method makes studying cancer proteins easier
3. Introducing Robofish: Leading the crowd in studying group dynamics
4. Studying cells in 3-D could reveal new cancer targets
5. New lab manual for studying the biology of the nervous system in Drosophila is released
6. Studying hair of ancient Peruvians answers questions about stress
7. Exploration by explosion: Studying the inner realm of living cells
8. Model microbial community for studying expanding dead zones characterized
9. Geologists studying groundwater arsenic levels in India empower Bengali women, children
10. K-State receives more than $780,000 to fund graduate students studying ecology, evolution, genomics
11. LSU receives $3.6 million to fund center studying hazardous waste cleanup and health impacts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2016)... 15, 2016 Research and Markets has announced ... 2021" report to their offering. ... ... by 2021 from USD 6.21 Billion in 2016, growing at a ... of the bioinformatics market is driven by the growing demand for ...
(Date:6/27/2016)... , June 27, 2016 Research and ... North America 2016-2020" report to their offering. ... North America to grow at a CAGR of ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
(Date:6/22/2016)... On Monday, the Department of Homeland Security (DHS) issued ... the Biometric Exit Program. The Request for Information (RFI), ... that CBP intends to add biometrics to confirm when ... , in order to deter visa overstays, to ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... N.J. , Dec. 8, 2016  Soligenix, ... late-stage biopharmaceutical company focused on developing and commercializing ... an unmet medical need, announced today the long-term ... with SGX942 (dusquetide), a first-in-class Innate Defense Regulator ... in head and neck cancer patients undergoing chemoradiation ...
(Date:12/8/2016)... Dec. 8, 2016  Partnering to fuel ... Technology Partners of Southeastern Pennsylvania ... parent company of Independence Blue Cross; and Safeguard Scientifics ... intentions for a $6 million funding initiative over a ... Responding to a burgeoning economic vitality in ...
(Date:12/7/2016)... 2016 Neogen Corporation (NASDAQ: NEOG ... Kephart as its chief science officer — a ... responsibilities at Neogen effective Jan. 1. Kephart ... agribusiness unit of Thermo Fisher Scientific, as well as ... His extensive industry experience also includes the management of ...
(Date:12/7/2016)... The report "Acrylic Processing Aid Market by Polymer Type (PVC), Fabrication Process (Extrusion, Injection ... to 2026", published by MarketsandMarkets, the global market size was USD 645.4 Million ... an of CAGR of 6.2% between 2016 and 2026. ... ... , , ...
Breaking Biology Technology: