Navigation Links
Study validates means to measure possible leukemia marker
Date:4/30/2009

COLUMBUS, Ohio A study led by cancer researchers at The Ohio State University has validated a method for reliably measuring variations in certain proteins that may make good biomarkers in chronic leukemia patients.

The study shows that liquid chromatography-mass spectrometry (LC-MS) can measure variations in histones, which are spool-like proteins that help support and store DNA. The technology accurately detected differences in the composition of histones in chronic lymphocytic leukemia (CLL) cells compared with their healthy counterparts, immune cells called B lymphocytes.

These variations are a promising molecular biomarker that might improve the diagnosis and gauge response to therapy in CLL patients.

The findings are published online in a recent issue of the journal Proteomics.

"Now that we have validated the technique, we can apply it to study histones as biomarkers that clinicians can use to make decisions about diagnosis and treatment," says principal investigator Michael A. Freitas, a researcher in the Ohio State University Comprehensive Cancer Center's Experimental Therapeutics Program.

Freitas and his colleagues used LC-MS to analyze variations in histones in 40 CLL patients and four healthy patients. It showed significant changes in the relative abundance of histone H2A variants in CLL cells compared with healthy B cells and suggested a correlation between these changes and the severity of CLL.

To verify the accuracy of their measurements, the investigators tested the technology against common sources of error that can arise in clinical testing laboratories. These included analyzing samples prepared in different ways and by different people, and using different instruments. They also re-analyzed samples that were nearly two years old.

"All of these can be huge problems in biomarker analysis," Freitas says. "The danger is that patients can end up being separated into groups based on c
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , Feb. 3, 2015 Despite ... demand from industries such as consumer electronics, automotive, ... for surface mount technology (SMT) screen printers. Innovations ... automatic control will push the adoption curve up. ... remain steady as glue dispensers are indispensable in ...
(Date:1/22/2015)... MELBOURNE, Fla. , Jan. 13, 2015  Today, ... wearable technology, launched its crowdfunding campaign on Fundable, ... accelerate the build of production capacity to meet ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... commerce market, reports on the recent success of the Wocket™ smart wallet ... Wocket smart wallet was named as one of the "11 Hot ... "5 Best Products Launched At CES So Far" by Newseveryday.com and "The ...
Breaking Biology News(10 mins):End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... Depression is the leading cause of disability with ... disease. In addition to debilitating consequences on mental health, ... heart disease, and conversely heart disease increases the risk ... by the year 2020 heart disease and depression will ...
... newly associated nine genetic regions with a rare autoimmune ... (PSC). This brings the total number of genetic regions ... per cent of people who suffer from PSC also ... of the newly associated genetic regions were shared with ...
... the number one killer in the U.S. for several decades. ... here. Obesity is a risk factor for both conditions and ... diabetics will die of cardiovascular disease. While this much ... still remains largely a mystery. Johnathan D. Tune, Ph.D., associate ...
Cached Biology News:Social stress and the inflamed brain 2Genetics defines a distinct liver disease 2Genetics defines a distinct liver disease 3Indiana University associate professor earns APS's Henry Pickering Bowditch Award 2Indiana University associate professor earns APS's Henry Pickering Bowditch Award 3
(Date:3/5/2015)... --  HX360 today announced that sixteen companies have ... Challenge competition. These companies, selected from a field ... one of four finalists to present their solutions live ... venture capitalists during the Innovation Challenge event. ... 2015 HIMSS Annual Conference & Exhibition, McCormick Place in ...
(Date:3/5/2015)... 2015 Bi-Biomics today announced a ... stain additive. The improvement in histological quality provided ... present in all daughter cells. , After processing ... was analyzed at 1000-1600x using light microscopy. ... in all daughter cells displayed predominant binary features ...
(Date:3/5/2015)... DUBLIN , Mar. 05, 2015 Research and ... addition of the "Mature Biotech Outlook 2015: New ... to their offering. All biotech companies ... Celgene (CELG), in past year, have given a positive ... These companies have been able to select therapy/niche indication ...
(Date:3/5/2015)... 05, 2015 RMI ... chronic orthopedic conditions such as meniscal tears, ACL ... and joint pain due to degenerative conditions like ... orthopedic surgeries to promote better post-surgical outcomes. , ... nearly pain-free bone marrow harvesting with two complimentary ...
Breaking Biology Technology:HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 2Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 3Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 2Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 3Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 4Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 5
... March 11 Raven,biotechnologies, inc., a privately held ... antibody therapeutics (MAbs) for cancer,today announced that an ... has been accepted as a poster discussion presentation ... of Clinical Oncology (ASCO).,The presentation is scheduled for ...
... 19, 2008 at 8:00 a.m. Eastern Time, TROY, ... is scheduled to participate in the Cowen & Company ... 17-20, 2008 at the,Boston Marriott Copley Place in Boston, ... executive officer,will make a 30-minute presentation on Wednesday, March ...
... 11 PAREXEL International,Corporation (Nasdaq: PRXL ) ... Brothers 11th Annual Global Healthcare Conference in Miami, ... will be making a,formal presentation on PAREXEL at ... A live webcast of this presentation will be ...
Cached Biology Technology:Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 2Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 3Somanetics Corporation to Present at Cowen & Company 28th Annual Health Care Conference 2PAREXEL International to Present at Lehman Brothers 11th Annual Global Healthcare Conference 2
Homo sapiens palladin...
Request Info...
IgD Chain C (AMS 9.1)...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: