Navigation Links
Study uncovers mechanism used by BRCA1 to suppress tumors
Date:12/17/2012

WASHINGTON -- A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth.

The findings, published online today in Oncogene, focus on the gene BRCA1, which is mutated in a majority of families who have hereditary breast and/or ovarian cancers, according to senior author Ronit I. Yarden, PhD, assistant professor in the Department of Human Science at the School of Nursing & Health Studies.

"There is a debate in the scientific community about whether BRCA1 enzymatic activity is important in tumor suppressor function," Yarden said. "My lab thinks it is."

Previous research by other investigators, according to Yarden, has shown that BRCA1 is an ubiquitin E3 ligase enzyme. When added to other proteins, ubiquitin has the ability to mark them for degradation and recycling.

Her laboratory worked to discover which proteins BRCA1 is targeting with ubiquitin and how that activity might help attenuate cell division in response to DNA damage a function that is important for maintaining genomic integrity and suppressing tumor growth.

"Cells have surveillance mechanisms and check points that govern cell division," she said. "In order to conduct DNA repair in a timely fashion, a cell must be stopped for awhile and then repaired. Once DNA is fixed, division can then begin again."

Yarden's lab discovered that BRCA1 targets two specific proteins cyclin B and Cdc25c, which are the "keeper genes" that regulate the G2/M checkpoint the last checkpoint a cell has to go through before it divides.

"The paper shows that in response to DNA damage, BRCA1 is responsible for tagging these two proteins to stop the cells from dividing so repair can occur," Yarden said. "This work shows that BRCA1 enzymatic function is essential for maintaining genomic integrity and may explain BRCA1 role in tumor suppression."

"We identified a novel function," she said. "Although different substrates for BRCA1 were previously identified by other investigators, those didn't explain directly BRCA1's role in maintenance of genomic integrity. Our new targets are the first to directly link this ubiquitination function of BRCA1 to halting cell division that is important for maintenance of genomic integrity and stability, an important activity of tumor suppression."


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Related biology news :

1. Penn Study shows resistance to cocaine addiction may be passed down from father to son
2. Study confirms prognostic value of new IASLC/ATS/ERS adenocarcinoma sub-classification
3. Study shows immunohistochemistry is reliable screening tool for ALK rearrangement
4. Study fuels insight into conversion of wood to bio-oil
5. Warming climate unlikely to cause extinction of ancient Amazon trees, study finds
6. University of Illinois receives grant to study ozone resistance in corn
7. OU study suggests the bacterial ecology that lives on humans has changed in the last 100 years
8. Study sheds light on how cells transport materials along crowded intercellular highways
9. Scientists develop novel method to study parasite numbers in wild seabirds
10. Mercyhurst University study probes impact of climate change on ectotherms
11. U of M to lead international virtual institute studying climatic and human effects on Earth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... , Jan. 25, 2016   Unisys Corporation (NYSE: ... at John F. Kennedy (JFK) International Airport, New York ... (CBP) identify imposters attempting to enter the United ... belong to them. pilot testing of the system ... at three terminals at JFK during January 2016. --> ...
(Date:1/22/2016)... January 22, 2016 ... addition of the  "Global Behavioral Biometric ... --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ... Behavioral Biometric Market 2016-2020"  report to ... and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced ...
(Date:1/21/2016)... 2016 --> ... research report "Emotion Detection and Recognition Market by Technology (Bio-Sensors, ... Expression, Voice Recognition and Others), Services, Application Areas, ... 2020", published by MarketsandMarkets, the global Emotion Detection ... 22.65 Billion by 2020, at a CAGR of ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... 2016 Sinovac Biotech Ltd. ("Sinovac" or the ... biopharmaceutical products in China , today ... directors received on February 4, 2016 a preliminary non-binding ... comprised of PKU V-Ming ( Shanghai ) ... Qianhai Development ( Shenzhen ) Fund Management ...
(Date:2/3/2016)... Feb. 3, 2016   ViaCyte, Inc ., ... first pluripotent stem cell-derived islet replacement therapy for ... development, today announced that ViaCyte and Janssen Biotech, ... Johnson & Johnson, have agreed to consolidate the ... The agreement provides ViaCyte with an exclusive license ...
(Date:2/3/2016)... 3, 2016 Harvard Apparatus Regenerative Technology, ... developing bioengineered organ implants for life-threatening conditions of ... CEO Jim McGorry , will present at ... on Tuesday, February 9, 2016 at 8:00 am ... . HART,s presentation will be webcast live and ...
(Date:2/3/2016)... ... 03, 2016 , ... StarNet Communications Corp, ( http://www.starnet.com/ ) ... addition of a powerful “Session Preview” feature to its FastX remote Linux visualization ... remote Linux desktop or other applications (sessions) they have running on a remote ...
Breaking Biology Technology: