Navigation Links
Study uncovers mechanism used by BRCA1 to suppress tumors
Date:12/17/2012

WASHINGTON -- A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth.

The findings, published online today in Oncogene, focus on the gene BRCA1, which is mutated in a majority of families who have hereditary breast and/or ovarian cancers, according to senior author Ronit I. Yarden, PhD, assistant professor in the Department of Human Science at the School of Nursing & Health Studies.

"There is a debate in the scientific community about whether BRCA1 enzymatic activity is important in tumor suppressor function," Yarden said. "My lab thinks it is."

Previous research by other investigators, according to Yarden, has shown that BRCA1 is an ubiquitin E3 ligase enzyme. When added to other proteins, ubiquitin has the ability to mark them for degradation and recycling.

Her laboratory worked to discover which proteins BRCA1 is targeting with ubiquitin and how that activity might help attenuate cell division in response to DNA damage a function that is important for maintaining genomic integrity and suppressing tumor growth.

"Cells have surveillance mechanisms and check points that govern cell division," she said. "In order to conduct DNA repair in a timely fashion, a cell must be stopped for awhile and then repaired. Once DNA is fixed, division can then begin again."

Yarden's lab discovered that BRCA1 targets two specific proteins cyclin B and Cdc25c, which are the "keeper genes" that regulate the G2/M checkpoint the last checkpoint a cell has to go through before it divides.

"The paper shows that in response to DNA damage, BRCA1 is responsible for tagging these two proteins to stop the cells from dividing so repair can occur," Yarden said. "This work shows that BRCA1 enzymatic function is essential for maintaining genomic integrity and may explain BRCA1 role in tumor suppression."

"We id
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Penn Study shows resistance to cocaine addiction may be passed down from father to son
2. Study confirms prognostic value of new IASLC/ATS/ERS adenocarcinoma sub-classification
3. Study shows immunohistochemistry is reliable screening tool for ALK rearrangement
4. Study fuels insight into conversion of wood to bio-oil
5. Warming climate unlikely to cause extinction of ancient Amazon trees, study finds
6. University of Illinois receives grant to study ozone resistance in corn
7. OU study suggests the bacterial ecology that lives on humans has changed in the last 100 years
8. Study sheds light on how cells transport materials along crowded intercellular highways
9. Scientists develop novel method to study parasite numbers in wild seabirds
10. Mercyhurst University study probes impact of climate change on ectotherms
11. U of M to lead international virtual institute studying climatic and human effects on Earth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... June 27, 2014  The American Academy of ... of Standards and Technology (NIST) and the Department ... research and forensic science expert members to the ... an element of the NIST,s Organization of Scientific ... the first appointments made to the new FSSB ...
(Date:7/10/2014)... , July 2, 2014  Unisys Corporation,s (NYSE: ... , Unisys Nederland N.V., today announced that it has been ... implement and manage a new Basic Provision Biometrics solution for ... Unisys won the contract with a solution based on ... software. The term of the contract is up to seven ...
(Date:7/10/2014)... , July 3, 2014 Research ... addition of the "Global Gesture Recognition & ... - Forecasts to 2020" report to their ... Global Gesture Recognition & Touch-Less Sensing Market ... around for a while, but the companies were ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... is "Molecule of the Year 2009". This was announced ... Society for Molecular and Cell Biology and Biotechnology Protocols ... Zsuzsanna Izsvk, Dr. Zoltn Ivics and Dr. Lajos Mts ... Berlin-Buch. According to the jury, it was selected out ...
... current controversy over vertebroplastya minimally invasive treatment performed ... vertebral compression fractures that fail to respond to ... your medical team to decide if you are ... experience of hundreds of thousands of other patients ...
... BOSTON (January 19, 2010, 12:00 noon EST) A study ... School of Graduate Biomedical Sciences at Tufts, and Tufts Medical ... cancer. The researchers propose a new model for breast cell ... which appears to be the cell of origin for luminal-like ...
Cached Biology News:'Sleeping Beauty' -- Molecule of the Year 2Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 2Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 3Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 4Cell of origin identified for common type of breast cancer 2
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, ... report to their offering. ... photonic integration traces its roots in the latter ... photonic integration went unexplored and unfulfilled for several ...
(Date:7/10/2014)... microscopic polymer light resonators that expand in the ... Photonics Laboratory have developed new optical sensors with ... sensors are ideal for detecting trace gas concentrations ... nature, and immunity to electromagnetic interference. , Although ... the MIT team conceived an extremely sensitive, compact ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and electric ... a single charge with the help of a sponge-like ... to replace the graphite traditionally used in one of ... times the energy storage capacity of graphite. A paper ... was published today in Nature Communications . , ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... DURHAM, N.C., Dec. 16 Parion Sciences, Inc., ... from the failure of the body,s mucosal defenses, ... have awarded the,company a biodefense grant in excess ... The purpose of the grant is to ...
... KRAS Biomarker PresentsPotential toPersonalize Colorectal Cancer Treatment Determining Who ... , THOUSAND OAKS, Calif., Dec. 16 Amgen ... discuss the clinical utility of the KRAS ... colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor ...
... 16 , - ... The American Journal of Medicine (AJM), one of ... Medicine blog,( http://amjmed.blogspot.com ), a dynamic forum where physicians and ... that have been published in the Journal. , ...
Cached Biology Technology:Parion Sciences Receives NIH Biodefense Grant to Study Novel Methods for Mitigating Radiation-Induced Lung Injury 2Parion Sciences Receives NIH Biodefense Grant to Study Novel Methods for Mitigating Radiation-Induced Lung Injury 3Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 2Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 3Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 4Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 5Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 6Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 7Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 8Elsevier Introduces The American Journal of Medicine Blog 2Elsevier Introduces The American Journal of Medicine Blog 3
... is the major proteolytic system in ... it catalyzes the selective degradation of ... elimination of proteins with abnormal conformation ... The critical protease in this pathway ...
... [1320] to RFC1 Immunogen Recombinant protein ... Factor C expressed in E. coli. Reactivity ... cerevisiae. Not yet tested in other species. This ... Background Information Replication factor C is ...
... Bacterial DNA Isolation Kit provides a rapid ... genomic DNA from the various bacterial species ... the isolation of genomic DNA from both ... milk samples. ,Purification is based on ...
... Chemicon Select Tissue Arrays are intended for ... tissues were fixed in neutral buffered formalin ... and diagnosis was performed by certified pathologists. ... paraffin blocks and relocated into a new ...
Biology Products: