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Study turns parasite invasion theory on its head
Date:12/23/2012

have only ever been able to reduce the expression level of these genes in the parasite, which did lead to a reduction in host cell invasion but invasion was never blocked completely. This was attributed to the low levels of gene expression that persisted. However, with the new technique, the team were able to completely remove the genes of interest. Unexpectedly they found that the parasites were still able to invade.

"One of the genes we looked at is the equivalent of a malaria gene that is a major candidate for vaccine development. Our findings would suggest that such a vaccine may not be successful at preventing malaria infection and we need to revisit our understanding of how this family of parasites invades host cells," added Dr Meissner.

As well as malaria, a number of other parasites that affect livestock also belong to the same family. The findings could also provide clues to new treatments for these diseases, which cause substantial economic losses worldwide.


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Contact: Jen Middleton
j.middleton@wellcome.ac.uk
Wellcome Trust
Source:Eurekalert

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