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Study tracks mutations causing CDA II back to the Roman Empire
Date:10/7/2011

resent work suggest that the E109K mutation might have been originated in Italian population approximately 2.200 years ago. These results are consistent with another study that estimates its origin 2.400 years ago in Israeli Moroccan Jews. As E109K is particularly common in this population, the authors hypothesize it was born in the Middle East 2.400 years ago and arrived in European regions approximately at the time of Caesar Augustus when Roman Empire had the maximum expansion.

On the other hand, for the most frequent mutation in Italian CDA II patients, R14W, the investigators estimated that this mutation would be originated approximately 3.000 years ago, at the time when much of Southern Italy was a Greek colony, the Magna Graecia. The geographic distribution of CDA II, showing a concentration of this disease in Southern Italy and in Mediterranean countries, supports the idea that a particular CDA II mutation arose or was introduced in Southern Italy, from where it might have spread over the rest of the country.


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Contact: Alex Argemi
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

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